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Journal of Cardiovascular Translational Research
Erschienen in: Journal of Cardiovascular Translational Research 4/2017

11.05.2017 | Original Article

Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System

verfasst von: Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2017

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Abstract

Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the female sex steroid, estrogen. Here, the NNCCS was shown to possess a circadian rhythm; its activity was upregulated in the light-off phase via histone acetyltransferase (HAT) activity and downregulated in the light-on phase. Disrupting the circadian rhythm altered the physiological choline acetyltransferase (ChAT) expression pattern. The NNCCS circadian rhythm may be regulated by miR-345, independently of HAT, causing decreased cardiac ChAT expression. Murine cardiac ChAT expression and ACh contents were increased more in female hearts than in male hearts. This upregulation was downregulated by treatment with the estrogen receptor antagonist tamoxifen, and in contrast, estrogen reciprocally regulated cardiac miR-345 expression. These results suggest that the NNCCS is regulated by the circadian rhythm and is affected by sexual dimorphism.
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Metadaten
Titel
Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System
verfasst von
Shino Oikawa
Yuko Kai
Asuka Mano
Hisayuki Ohata
Takahiro Nemoto
Yoshihiko Kakinuma
Publikationsdatum
11.05.2017
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 4/2017
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-017-9750-4

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