Erschienen in:
01.08.2013 | Poster presentation
Vascular smooth muscle cell activation depends on NOS-1-derived NO and consequent peroxynitrite generation
verfasst von:
Karin Scheschowitsch, Regina de Sordi, João Alfredo de Moraes, Christina Barja-Fidalgo, Jamil Assreuy
Erschienen in:
Critical Care
|
Sonderheft 4/2013
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Excerpt
Low levels of nitric oxide (NO) play a key role in vascular tonus maintenance. Previous results from our laboratory show that hypotension and mortality during sepsis are prevented by the early administration of NOS-1 inhibitors. The aim of this study was thus to investigate the role of NOS-1 and NOS-3-derived NO and of other reactive oxygen species (ROS) in smooth muscle cell activation. …