Erschienen in:
Open Access
01.04.2013 | Poster presentation
Vasopressin reduces the cumulative epinephrine dose in hypothermic swine with traumatic brain injury
verfasst von:
AD Goldberg, MG Kashiouris, L Keenan, A Rabinstein, M Kumar
Erschienen in:
Critical Care
|
Sonderheft 2/2013
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Excerpt
Prevention of secondary neurologic injuries is paramount for improved neurologic outcomes after traumatic brain injury (TBI). Evidence suggests that although therapeutic hypothermia (TH) lowers intracranial pressure and attenuates secondary cerebral insults after TBI [
1], it also induces hypotension. Brief episodes of mild hypotension in brain-injured patients can trigger secondary injuries, which have been associated with increased mortality in patients with TBI [
2]. Vasopressin mitigates hypotension in septic shock and improves coronary perfusion in hypothermic cardiac arrest models [
3]. We hypothesized that a low-dose vasopressin infusion may reduce the cumulative epinephrine dose in hypothermic, brain-injured swine. …