Introduction
Methods
Baseline assessment
25[OH]D concentration
Hospitalisation and mortality
Statistical methods
Whole cohort | 25[OH]D < 50 | 25[OH]D ≥ 50 | p value | Missing | |
---|---|---|---|---|---|
n = 1802 | n = 914 | n = 338 | 25[OH]D groups | n (%) | |
Age (years) | 69.6 (12.5) | 69.9 (12.7) | 71.2 (11.2) | 0.07 | 0 (0) |
Heart rate (bpm) | 75.3 (17.9) | 76.4 (18.3) | 73.6 (17.2) | 0.017 | 158 (8.8) |
QRS interval (ms) | 123.2 (31) | 123.8 (31.4) | 123.7 (31.4) | 0.94 | 157 (8.7) |
Haemoglobin (g/dl) | 13.5 (1.8) | 13.5 (1.8) | 13.4 (1.8) | 0.35 | 20 (1.1) |
Sodium (mmol/L) | 139.4 (3.4) | 139.2 (3.5) | 139.9 (3) | 0.001 | 4 (0.2) |
eGFR (ml/kg/1.73 m2) | 57.8 (19.7) | 58.5 (19.5) | 57.3 (20.7) | 0.36 | 8 (0.4) |
Albumin (g/l) | 43.1 (11.1) | 42.8 (3.7) | 43.1 (3.8) | 0.29 | 56 (3.1) |
LV end diastolic dimension (mm) | 57.2 (8.9) | 57 (8.6) | 56.7 (8.9) | 0.53 | 71 (3.9) |
LV ejection fraction (%) | 32 (9.5) | 31.6 (9.3) | 32.2 (9.4) | 0.26 | 45 (2.5) |
Ramipril dose (mg/day) | 4.9 (3.5) | 4.8 (3.6) | 5 (3.5) | 0.37 | 5 (0.3) |
Bisoprolol dose (mg/day) | 3.9 (3.4) | 4 (3.4) | 4 (3.3) | 0.89 | 5 (0.3) |
Prescribed ACEi/ARB (n, %) | 1626 (90.4) | 818 (89.7) | 309 (91.4) | 0.36 | 5 (0.3) |
Prescribed beta-blocker (n, %) | 1523 (84.7) | 782 (85.7) | 289 (85.5) | 0.91 | 5 (0.3) |
Prescribed mineralocorticoid receptor antagonist (n, %) | 689 (38.2) | 367 (40.2) | 111 (32.8) | 0.017 | 5 (0.3) |
Furosemide (mg/day) | 51.2 (1.2) | 54.4 (1.6) | 44.1 (2.6) | 0.001 | 5 (0.3) |
Male sex (n, %) | 1319 (73.2) | 678 (74.2) | 230 (68) | 0.031 | 0 (0) |
Ischaemic aetiology (n, %) | 1067 (59.2) | 544 (59.5) | 187 (55.3) | 0.18 | 0 (0) |
Diabetes (n, %) | 504 (28) | 287 (31.4) | 77 (22.8) | 0.003 | 0 (0) |
COPD (n, %) | 284 (15.8) | 144 (15.8) | 52 (15.4) | 0.87 | 0 (0) |
Device therapy (n, %) | 504 (28) | 247 (27) | 109 (32.2) | 0.07 | 0 (0) |
NYHA class 1 (n, %) | 333 (18.5) | 132 (14.4) | 66 (19.5) | 0.05 | 2 (0.1) |
2 | 912 (50.7) | 478 (52.3) | 179 (53) | ||
3 | 534 (29.7) | 294 (32.2) | 92 (27.2) | ||
4 | 21 (1.2) | 10 (1.1) | 1 (0.3) |
Results
Hospitalisation and mortality outcomes
Model | OR** | Lower 95% CI | Upper 95% CI | p value |
---|---|---|---|---|
Heart failure hospitalisation (n = 112, 6.2%) | ||||
Unadjusted | 0.67 | 0.46 | 0.97 | 0.034 |
Adjusted for patient and clinical demographicsa | 0.76 | 0.52 | 1.12 | 0.165 |
Adjusted for patient and clinical demographics, and comorbidities and aetiologyb | 0.79 | 0.54 | 1.16 | 0.223 |
Adjusted for patient and clinical demographics, comorbidities and aetiology, and treatmentc | 0.80 | 0.54 | 1.19 | 0.270 |
Cardiovascular hospitalisation (n = 227, 12.6%) | ||||
Unadjusted | 0.78 | 0.59 | 1.01 | 0.061 |
Adjusted for patient and clinical demographicsa | 0.84 | 0.64 | 1.10 | 0.202 |
Adjusted for patient and clinical demographics, and comorbidities and aetiologyb | 0.86 | 0.65 | 1.13 | 0.280 |
Adjusted for patient and clinical demographics, comorbidities and aetiology, and treatmentc | 0.87 | 0.66 | 1.15 | 0.330 |
All non-elective hospitalisations (457, 25.4%) | ||||
Unadjusted | 0.78 | 0.64 | 0.95 | 0.011 |
Adjusted for patient and clinical demographicsa | 0.84 | 0.68 | 1.03 | 0.086 |
Adjusted for patient and clinical demographics, and comorbidities and aetiologyb | 0.85 | 0.69 | 1.04 | 0.111 |
Adjusted for patient and clinical demographics, comorbidities and aetiology, and treatmentc | 0.86 | 0.70 | 1.05 | 0.139 |
Model | HRa | Lower 95% CI | Upper 95% CI | p value |
---|---|---|---|---|
All-cause mortality (n = 737, 40.9%) | ||||
Unadjusted | 0.79 | 0.69 | 0.91 | 0.001 |
Adjusted for patient and clinical demographicsb | 0.83 | 0.72 | 0.96 | 0.011 |
Adjusted for patient and clinical demographics, and comorbidities and aetiologyc | 0.84 | 0.72 | 0.97 | 0.016 |
Adjusted for patient and clinical demographics, comorbidities and aetiology, and treatmentd | 0.86 | 0.74 | 0.99 | 0.042 |