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Current Hepatology Reports
Erschienen in: Current Hepatology Reports 4/2017

24.10.2017 | Fatty Liver Disease (S Harrison and J George, Section Editors)

Wet Biomarker-Based Assessment of Steatosis, Inflammation, and Fibrosis in NAFLD

verfasst von: Peter Lykke Eriksen, Karen Louise Thomsen, Tea Lund Laursen, Konstantin Kazankov, Sara Heebøll, Henning Grønbæk

Erschienen in: Current Hepatology Reports | Ausgabe 4/2017

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Abstract

Purpose of Review

Non-alcoholic fatty liver disease (NAFLD) is a disease on the rise; the severe form with steatohepatitis (NASH) may progress to liver cirrhosis with increased morbidity and mortality. Non-invasive biomarkers for the diagnosis of NASH with fibrosis are an area of intensive research. We review the current literature and new research on wet biomarkers for the diagnosis of NASH and fibrosis.

Recent Findings

A number of single parameters as well as composite scores show acceptable efficacy for the prediction of NASH and fibrosis. Composite scores generally use parameters that are usually easily accessible or commercially available. Other markers include the apoptosis marker CK-18, the macrophage activation marker soluble (s)CD163, and others.

Summary

From a clinical point of view, the FIB-4 and NAFLD fibrosis score perform well and are easily accessible compared to some of the commercially available tests. CK-18 and sCD163 are promising for both NASH diagnosis and resolution but need further validation and assay standardisation. The combination of these biomarkers with imaging techniques, e.g. fibroscan, may work synergistically to improve NASH diagnosis and follow-up in the future.
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Metadaten
Titel
Wet Biomarker-Based Assessment of Steatosis, Inflammation, and Fibrosis in NAFLD
verfasst von
Peter Lykke Eriksen
Karen Louise Thomsen
Tea Lund Laursen
Konstantin Kazankov
Sara Heebøll
Henning Grønbæk
Publikationsdatum
24.10.2017
Verlag
Springer US
Erschienen in
Current Hepatology Reports / Ausgabe 4/2017
Elektronische ISSN: 2195-9595
DOI
https://doi.org/10.1007/s11901-017-0369-3

Weitere Artikel der Ausgabe 4/2017

Current Hepatology Reports 4/2017 Zur Ausgabe

Fatty Liver Disease (S Harrison and J George, Section Editors)

Non-alcoholic Fatty Liver Disease in Non-obese Patients

Fatty Liver Disease (S Harrison and J George, Section Editors)

What Is the Optimal Dietary Composition for NAFLD?

Fatty Liver Disease (S Harrison and J George, Section Editors)

Imaging-Based Assessment of Steatosis, Inflammation and Fibrosis in NAFLD

Drug-Induced Liver Injury (F Bessone and R Andrade, Section Editors)

Hepatotoxicity of New Antitumor Agents

Portal Hypertension (E Tsochatzis and J Abraldes, Section Editors)

The Management of Bleeding from Anorectal Varices

Fatty Liver Disease (S Harrison and J George, Section Editors)

Role of Exercise in NAFLD/NASH: What is the Right Prescription?

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RAS-Blocker bei Hyperkaliämie möglichst nicht sofort absetzen

14.05.2024 Hyperkaliämie Nachrichten

Bei ausgeprägter Nierenfunktionsstörung steigen unter der Einnahme von Renin-Angiotensin-System(RAS)-Hemmstoffen nicht selten die Serumkaliumspiegel. Was in diesem Fall zu tun ist, erklärte Prof. Jürgen Floege beim diesjährigen Allgemeinmedizin-Update-Seminar.

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

13.05.2024 Pankreaskarzinom Nachrichten

Gerade bei aggressiven Malignomen wie dem duktalen Adenokarzinom des Pankreas könnte Früherkennung die Therapiechancen verbessern. Noch jedoch klafft hier eine Lücke. Ein Studienteam hat einen Weg gesucht, sie zu schließen.

Battle of Experts: Sport vs. Spritze bei Adipositas und Typ-2-Diabetes

11.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Im Battle of Experts traten zwei Experten auf dem Diabeteskongress gegeneinander an: Die eine vertrat die Auffassung „Sport statt Spritze“ bei Adipositas und Typ-2-Diabetes, der andere forderte „Spritze statt Sport!“ Am Ende waren sie sich aber einig: Die Kombination aus beidem erzielt die besten Ergebnisse.

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