Skip to main content
Erschienen in: International Journal of Legal Medicine 6/2015

01.11.2015 | Method Paper

Whole-body post-mortem computed tomography angiography of a newborn revealing transposition of great arteries

verfasst von: Krzysztof Jerzy Woźniak, Artur Moskała, Piotr Kluza, Karol Romaszko, Oleksiy Lopatin, Ewa Rzepecka-Woźniak

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

The number of medico-legal post-mortem examinations referring to newborns is considerably low: In the case of the Chair and Department of Forensic Medicine of the author’s origin, the autopsy rate of such cases is less than 1 %. Even experienced forensic pathologists can find the technical autopsy procedure of a newborn quite difficult. Post-mortem imaging using unenhanced post-mortem computed tomography (PMCT) gives only a limited opportunity to help in conventional autopsy examination. By adding contrast medium (CA) administration, we can significantly expand diagnostic capabilities. However, the post-mortem computed tomography angiography (PMCTA) technique has already been developed mostly in adult death cases (as considerably much more frequent), and no standardised protocol for examination of children exists. The authors present the dual-phase PMCTA examination of a newborn by manual CA administration using the access to umbilical vessels (vein and artery) unveiling transposition of the great arteries (TGA). The results are presented as multiplanar reformatted (MPR) images and three-dimensional (3D) images by volume/surface-rendered reconstructions, giving a contribution towards proving the value of forensic imaging in post-mortem examinations of heart and vascular malformations in newborns.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM (2009) Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374(9688):467–475. doi:10.1016/S0140-6736(09)60913-2 CrossRefPubMed Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM (2009) Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374(9688):467–475. doi:10.​1016/​S0140-6736(09)60913-2 CrossRefPubMed
3.
Zurück zum Zitat Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM, MARIAS collaborative group (2013) Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 382(9888):223–233. doi:10.1016/S0140-6736(13)60134-8 CrossRefPubMed Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM, MARIAS collaborative group (2013) Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 382(9888):223–233. doi:10.​1016/​S0140-6736(13)60134-8 CrossRefPubMed
4.
Zurück zum Zitat Sarikouch S, Haas NA, Schaeffler R, Beerbaum P (2008) Value of postmortem magnetic resonance imaging for fatal neonatal congenital heart disease: a case report. Pediatr Cardiol 29(3):667–669CrossRefPubMed Sarikouch S, Haas NA, Schaeffler R, Beerbaum P (2008) Value of postmortem magnetic resonance imaging for fatal neonatal congenital heart disease: a case report. Pediatr Cardiol 29(3):667–669CrossRefPubMed
5.
6.
Zurück zum Zitat Arthurs OJ, Calder AD, Klein WM (2015) Is there still a role for fetal and perinatal post-mortem radiography? J Forensic Radiol Imaging 3(2):5–11CrossRef Arthurs OJ, Calder AD, Klein WM (2015) Is there still a role for fetal and perinatal post-mortem radiography? J Forensic Radiol Imaging 3(2):5–11CrossRef
7.
8.
Zurück zum Zitat Chevallier C, Doenz F, Vaucher P, Palmiere C, Dominguez A, Binaghi S, Mangin P, Grabherr S (2013) Postmortem computed tomography angiography vs. conventional autopsy: advantages and inconveniences of each method. Int J Legal Med 127(5):981–989. doi:10.1007/s00414-012-0814-3 CrossRefPubMed Chevallier C, Doenz F, Vaucher P, Palmiere C, Dominguez A, Binaghi S, Mangin P, Grabherr S (2013) Postmortem computed tomography angiography vs. conventional autopsy: advantages and inconveniences of each method. Int J Legal Med 127(5):981–989. doi:10.​1007/​s00414-012-0814-3 CrossRefPubMed
11.
Zurück zum Zitat Ferencz C, Rubin JD, McCarter RJ, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW (1985) Congenital heart disease: prevalence at livebirth. The Baltimore–Washington Infant Study. Am J Epidemiol 121:31–36PubMed Ferencz C, Rubin JD, McCarter RJ, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW (1985) Congenital heart disease: prevalence at livebirth. The Baltimore–Washington Infant Study. Am J Epidemiol 121:31–36PubMed
14.
Zurück zum Zitat van Velzen CL, Haak MC, Reijnders G, Rijlaarsdam ME, Bax CJ, Pajkrt E, Hruda J, Galindo-Garre F, Bilardo CM, de Groot CJ, Blom NA, Clur SA (2015) Prenatal detection of transposition of the great arteries reduces mortality and morbidity. Ultrasound Obstet Gynecol 45(3):320–325. doi:10.1002/uog.14689 CrossRefPubMed van Velzen CL, Haak MC, Reijnders G, Rijlaarsdam ME, Bax CJ, Pajkrt E, Hruda J, Galindo-Garre F, Bilardo CM, de Groot CJ, Blom NA, Clur SA (2015) Prenatal detection of transposition of the great arteries reduces mortality and morbidity. Ultrasound Obstet Gynecol 45(3):320–325. doi:10.​1002/​uog.​14689 CrossRefPubMed
15.
Zurück zum Zitat Proisy M, Loget P, Bouvet R, Roussey M, Pelé F, Rozel C, Treguier C, Darnault P, Bruneau B (2015) Non-specific post-mortem modifications on whole-body post-mortem computed tomography in sudden unexpected death in infancy. J Forensic Radiol Imaging 3(2):16–238CrossRef Proisy M, Loget P, Bouvet R, Roussey M, Pelé F, Rozel C, Treguier C, Darnault P, Bruneau B (2015) Non-specific post-mortem modifications on whole-body post-mortem computed tomography in sudden unexpected death in infancy. J Forensic Radiol Imaging 3(2):16–238CrossRef
21.
22.
Zurück zum Zitat Vogel B, Heinemann A, Gehl A, Hasegawa I, Höpker WW, Poodendaen C, Tzikas A, Gulbins H, Reichenspurner H, Püschel K, Vogel H (2013) Post-mortem computed tomography (PMCT) and PMCT-angiography after transvascular cardiac interventions. Arch Med Sadowej Kryminol 63:255–266PubMed Vogel B, Heinemann A, Gehl A, Hasegawa I, Höpker WW, Poodendaen C, Tzikas A, Gulbins H, Reichenspurner H, Püschel K, Vogel H (2013) Post-mortem computed tomography (PMCT) and PMCT-angiography after transvascular cardiac interventions. Arch Med Sadowej Kryminol 63:255–266PubMed
23.
Zurück zum Zitat Vogel B, Heinemann A, Tzikas A, Poodendaen C, Gulbins H, Reichenspurner H, Püschel K, Vogel H (2013) Post-mortem computed tomography (PMCT) and PMCT-angiography after cardiac surgery. Possibilities and limits. Arch Med Sadowej Kryminol 63:155–171PubMed Vogel B, Heinemann A, Tzikas A, Poodendaen C, Gulbins H, Reichenspurner H, Püschel K, Vogel H (2013) Post-mortem computed tomography (PMCT) and PMCT-angiography after cardiac surgery. Possibilities and limits. Arch Med Sadowej Kryminol 63:155–171PubMed
24.
25.
Zurück zum Zitat Votino C, Cannie M, Segers V, Dobrescu O, Dessy H, Gallo V, Cos T, Damry N, Jani J (2012) Virtual autopsy by computed tomographic angiography of the fetal heart: a feasibility study. Ultrasound Obstet Gynecol 39(6):679–684. doi:10.1002/uog.11150 CrossRefPubMed Votino C, Cannie M, Segers V, Dobrescu O, Dessy H, Gallo V, Cos T, Damry N, Jani J (2012) Virtual autopsy by computed tomographic angiography of the fetal heart: a feasibility study. Ultrasound Obstet Gynecol 39(6):679–684. doi:10.​1002/​uog.​11150 CrossRefPubMed
26.
27.
Zurück zum Zitat Sarda-Quarello L, Tuchtan L, Torrents J, Piercecchi-Marti MD, Bartoli C, Laurent PE, Bourliére-Najean B, Petit P, Quarello E, Gorincour G (2015) Perinatal death: is there a place for post-mortem angio-CT? J Forensic Radiol Imaging 3(2):1–4CrossRef Sarda-Quarello L, Tuchtan L, Torrents J, Piercecchi-Marti MD, Bartoli C, Laurent PE, Bourliére-Najean B, Petit P, Quarello E, Gorincour G (2015) Perinatal death: is there a place for post-mortem angio-CT? J Forensic Radiol Imaging 3(2):1–4CrossRef
Metadaten
Titel
Whole-body post-mortem computed tomography angiography of a newborn revealing transposition of great arteries
verfasst von
Krzysztof Jerzy Woźniak
Artur Moskała
Piotr Kluza
Karol Romaszko
Oleksiy Lopatin
Ewa Rzepecka-Woźniak
Publikationsdatum
01.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Legal Medicine / Ausgabe 6/2015
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI
https://doi.org/10.1007/s00414-015-1267-2

Weitere Artikel der Ausgabe 6/2015

International Journal of Legal Medicine 6/2015 Zur Ausgabe

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Open Access Biomarker Leitthema

Um auch an kleinen Gewebeproben zuverlässige und reproduzierbare Ergebnisse zu gewährleisten ist eine strenge Qualitätskontrolle in jedem Schritt des Arbeitsablaufs erforderlich. Eine nicht ordnungsgemäße Prüfung oder Behandlung des …

Vergleichende Pathologie in der onkologischen Forschung

Pathologie Leitthema

Die vergleichende experimentelle Pathologie („comparative experimental pathology“) ist ein Fachbereich an der Schnittstelle von Human- und Veterinärmedizin. Sie widmet sich der vergleichenden Erforschung von Gemeinsamkeiten und Unterschieden von …

Gastrointestinale Stromatumoren

Open Access GIST CME-Artikel

Gastrointestinale Stromatumoren (GIST) stellen seit über 20 Jahren ein Paradigma für die zielgerichtete Therapie mit Tyrosinkinaseinhibitoren dar. Eine elementare Voraussetzung für eine mögliche neoadjuvante oder adjuvante Behandlung bei …

Personalisierte Medizin in der Onkologie

Aufgrund des erheblichen technologischen Fortschritts in der molekularen und genetischen Diagnostik sowie zunehmender Erkenntnisse über die molekulare Pathogenese von Krankheiten hat in den letzten zwei Jahrzehnten ein grundlegender …