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12.11.2019 | Research Article

[^99mTc]MIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia

verfasst von: Shuzhen Chen, Malam Djibo Issa, Chenghong Wang, Liang Feng, Fei Teng, Bing Li, Yougui Pan, Xiaolong Zhang, Yifei Xu, Zhuoyu Zhang, Junhui Su, Hongxing Ma, Lingjing Jin

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2020

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Abstract

Purpose

This study aimed to evaluate the usefulness of [^99mTc]sestamibi ([^99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy.

Procedures

Thirty-six patients with PCD and 10 healthy subjects (control group) who underwent [^99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD group and normal muscles in control group. In PCD patients, target muscles injected with BoNT-A were selected by clinical evaluations and the results of needle electromyography (EMG) were considered as the gold standard. The sensitivity, specificity, and diagnostic efficacy of SPECT/CT were obtained from the receiver operator characteristic (ROC) curve.

Results

Twenty-four PCD patients were included in our study eventually, because three PCD patients whose follow-up were lost and 9 PCD patients whose maximum reduction of Tsui scale scores was < 80 % were ruled out. Normal muscles of healthy subjects showed mild symmetrical radioactivity distribution, while in PCD patients, [^99mTc]MIBI uptake in dystonic muscles abnormally increased. The mean MBRs of dystonic muscles were significantly higher than those of normal muscles. The sensitivity, specificity, and area under the curve (AUC) of SPECT/CT were 93.2 %, 88.5 %, and 0.908, respectively.

Conclusions

Our study indicated that [^99mTc]MIBI SPECT/CT may be a useful method for identifying dystonic muscles and a guide to BoNT-A therapy in PCD patients.

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Titel: [99mTc]MIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia
verfasst von: Shuzhen Chen
Malam Djibo Issa
Chenghong Wang
Liang Feng
Fei Teng
Bing Li
Yougui Pan
Xiaolong Zhang
Yifei Xu
Zhuoyu Zhang
Junhui Su
Hongxing Ma
Lingjing Jin
Publikationsdatum: 12.11.2019
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 4/2020
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-019-01436-0

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[^99mTc]MIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia