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Journal of Nuclear Cardiology

Erschienen in:

18.09.2019 | Editorial

A big step towards clinical implementation of myocardial blood flow quantification with CZT SPECT

verfasst von: Matthieu Pelletier-Galarneau, MD, MSc, Terrence D. Ruddy, MD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2021

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Excerpt

One of the main benefits of positron emission tomography (PET) myocardial perfusion imaging (MPI) over other imaging techniques is its ability to perform accurate myocardial blood flow (MBF) quantification.1 Quantification of MBF has been shown to increase diagnostic performance of PET MPI,2‐4 an increase attributed in part to improved detection of multivessel disease and identification of sub-optimal response to pharmacological stress.1,4,5 In addition, integration of flow quantification with PET MPI leads to better risk stratification of patients with coronary artery disease, as demonstrated by a significant increase of major cardiovascular events and deaths in patients with reduced myocardial flow reserve (MFR), even in the absence of inducible ischemia or scar on perfusion imaging.6,7 Moreover, the prognostic value of flow quantification has been established in various populations, such as patients with diabetes8 and kidney failure,9,10 as well as in several non-ischemic cardiomyopathies.11 …

Pelletier-Galarneau M, Martineau P, El Fakhri G. Quantification of PET Myocardial blood flow. Curr Cardiol Rep 2019;21:11. https://doi.org/10.1007/s11886-019-1096-x.CrossRefPubMed

Fiechter M, Ghadri JR, Gebhard C, et al. Diagnostic value of 13 N-ammonia myocardial perfusion PET: Added value of myocardial flow reserve. J Nucl Med 2012;53:1230-4. https://doi.org/10.2967/jnumed.111.101840.CrossRefPubMed

Muzik O, Duvernoy C, Beanlands RS, et al. Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol 1998;31:534-40.CrossRef

Ziadi MC, Dekemp RA, Williams K, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol 2012;19:670-80. https://doi.org/10.1007/s12350-011-9506-5.CrossRefPubMed

Naya M, Murthy VL, Taqueti VR, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014;55:248-55. https://doi.org/10.2967/jnumed.113.121442.CrossRefPubMed

Ziadi MC, Dekemp RA, Williams KA, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol 2011;58:740-8. https://doi.org/10.1016/j.jacc.2011.01.065.CrossRefPubMed

Murthy VL, Naya M, Foster CR, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 2011;124:2215-24. https://doi.org/10.1161/CIRCULATIONAHA.111.050427.CrossRefPubMedPubMedCentral

Murthy VL, Naya M, Foster CR, et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation 2012;126:1858-68. https://doi.org/10.1161/CIRCULATIONAHA.112.120402.CrossRefPubMedPubMedCentral

Murthy VL, Naya M, Foster CR, et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging 2012;5:1025-34. https://doi.org/10.1016/j.jcmg.2012.06.007.CrossRefPubMedPubMedCentral

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Shah NR, Charytan DM, Murthy VL, et al. Prognostic value of coronary flow reserve in patients with dialysis-dependent ESRD. J Am Soc Nephrol 2016;27:1823-9. https://doi.org/10.1681/ASN.2015030301.CrossRefPubMed

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Murthy VL, Bateman TM, Beanlands RS, et al. Clinical quantification of myocardial blood flow using PET: Joint position paper of the SNMMI Cardiovascular Council and the ASNC. J Nucl Cardiol 2018;25:269-97. https://doi.org/10.1007/s12350-017-1110-x.CrossRefPubMed

12.

Wells RG, Timmins R, Klein R, et al. Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model. J Nucl Med 2014;55:1685-91. https://doi.org/10.2967/jnumed.114.139782.CrossRefPubMed

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Wells RG, Marvin B, Poirier M, et al. Optimization of SPECT measurement of myocardial blood flow with corrections for attenuation, motion, and blood binding compared with PET. J Nucl Med 2017;58:2013-9. https://doi.org/10.2967/jnumed.117.191049.CrossRefPubMed

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Nkoulou R, Fuchs TA, Pazhenkottil AP, et al. Absolute myocardial blood flow and flow reserve assessed by gated SPECT with cadmium–zinc–telluride detectors using 99mTc-Tetrofosmin: Head-to-head comparison with 13N-ammonia PET. J Nucl Med 2016;57:1887-92. https://doi.org/10.2967/jnumed.115.165498.CrossRefPubMed

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Agostini D, Roule V, Nganoa C, et al. First validation of myocardial flow reserve assessed by dynamic 99mTc-sestamibi CZT-SPECT camera: Head to head comparison with 15O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study. Eur J Nucl Med Mol Imaging 2018;45:1079-90. https://doi.org/10.1007/s00259-018-3958-7.CrossRefPubMedPubMedCentral

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Ben-Haim S, Murthy VL, Breault C, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: A feasibility study. J Nucl Med 2013;54:873-9. https://doi.org/10.2967/jnumed.112.109652.CrossRefPubMed

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Ben Bouallègue F, Roubille F, Lattuca B, et al. SPECT myocardial perfusion reserve in patients with multivessel coronary disease: Correlation with angiographic findings and invasive fractional flow reserve measurements. J Nucl Med 2015;56:1712-7. https://doi.org/10.2967/jnumed.114.143164.CrossRefPubMed

18.

de Souza AC, Gonçalves BK, Tedeschi AL, Lima RS. Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease. J Nucl Cardiol 2019. https://doi.org/10.1007/s12350-019-01775-z.CrossRefPubMed

19.

Zavadovsky KV, Mochula AV, Boshchenko AA, et al. Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy. J Nucl Cardiol 2019. https://doi.org/10.1007/s12350-019-01678-z.CrossRefPubMed

20.

Otaki Y, Manabe O, Miller R, et al. Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with 15O-water PET. J Nucl Cardiol 2019. https://doi.org/10.1007/s12350-019-01854-1.CrossRefPubMedPubMedCentral

Titel: A big step towards clinical implementation of myocardial blood flow quantification with CZT SPECT
verfasst von: Matthieu Pelletier-Galarneau, MD, MSc
Terrence D. Ruddy, MD
Publikationsdatum: 18.09.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 4/2021
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-019-01894-7

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A big step towards clinical implementation of myocardial blood flow quantification with CZT SPECT

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