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Current Dermatology Reports

Erschienen in:

22.10.2018 | Immunology (D Lee, Section Editor)

Advances in Immune Pathways and Pathogenesis of Atopic Dermatitis

verfasst von: Houmin Li, Delphine J. Lee, Meiling Yuen

Erschienen in: Current Dermatology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. This review aims to summarize the advances in immune pathways and pathogenesis of AD.

Recent Findings

We review and summarize the current literature characterizing immune pathways and pathogenesis of AD. The complex interplay among skin barrier deficiency, immunological derangement, microbiome dysbiosis especially Staphylococcus aureus predominance, and pruritus contribute to the development, progression, and chronicity of the disease.

Summary

AD is a complex and multifactorial disease. The skin barrier, dysbiosis of the skin microbiome, immune dysregulation, and severe itch all play a part in the pathogenesis of AD. Based on this progress, better targeted therapies are now emerging.

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Titel: Advances in Immune Pathways and Pathogenesis of Atopic Dermatitis
verfasst von: Houmin Li
Delphine J. Lee
Meiling Yuen
Publikationsdatum: 22.10.2018
Verlag: Springer US
Erschienen in: Current Dermatology Reports / Ausgabe 4/2018
Elektronische ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-018-0238-5

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Abstract

Purpose of Review

Recent Findings

Summary

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