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Journal of Neural Transmission

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25.02.2017 | Neurology and Preclinical Neurological Studies - Review Article

Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates

verfasst von: Adriana Galvan, Michael J. Caiola, Daniel L. Albaugh

Erschienen in: Journal of Neural Transmission | Ausgabe 3/2018

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Abstract

Over the last 10 years, the use of opto- and chemogenetics to modulate neuronal activity in research applications has increased exponentially. Both techniques involve the genetic delivery of artificial proteins (opsins or engineered receptors) that are expressed on a selective population of neurons. The firing of these neurons can then be manipulated using light sources (for opsins) or by systemic administration of exogenous compounds (for chemogenetic receptors). Opto- and chemogenetic tools have enabled many important advances in basal ganglia research in rodent models, yet these techniques have faced a slow progress in non-human primate (NHP) research. In this review, we present a summary of the current state of these techniques in NHP research and outline some of the main challenges associated with the use of these genetic-based approaches in monkeys. We also explore cutting-edge developments that will facilitate the use of opto- and chemogenetics in NHPs, and help advance our understanding of basal ganglia circuits in normal and pathological conditions.

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Titel: Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates
verfasst von: Adriana Galvan
Michael J. Caiola
Daniel L. Albaugh
Publikationsdatum: 25.02.2017
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 3/2018
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1697-8

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