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28.03.2022 | Original Article

Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience

verfasst von: Pınar Tığlıoğlu, Murat Albayrak, Abdulkerim Yıldız, Mesut Tığlıoğlu, Buğra Sağlam, Merih Reis Aras, Fatma Yılmaz, Senem Maral, Hacer Berna Afacan Öztürk, Ümit Yavuz Malkan

Erschienen in: Journal of Hematopathology | Ausgabe 2/2022

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Abstract

In some patients with chronic myeloproliferative neoplasms, myelofibrosis (MF) develops as natural evolution of the disease. The aim of this study was to analyze predictive factors that may cause MF in polycythemia vera (PV) and essential thrombocythemia (ET) patients. This retrospective study was conducted on PV and ET patients who attended our hospital between 2008 and 2019. The development of MF during follow-up was recorded, and comparisons were made of the patients who developed MF and those who did not develop MF. Evaluation was made of 126 ET and 105 PV patients. During follow-up period, MF had developed 5.7% of PV and 7.1% of ET patients. It was determined that JAK-2 mutant allele burden, lymphocyte count, vitaminB12 levels, and grade of bone marrow fibrosis at diagnosis had statistically significant impact on the development of MF in all patients. In the logistic-regression analysis, it was found that initial hemoglobin, hematocrit, neutrophil-to-lymphocyte ratio, and monocyte count for PV patients; vitaminB12, the presence of splenomegaly; and BM fibrosis at diagnosis for ET patients have statistically significant effect on MF development. The results of the current study demonstrated that some parameters especially vitamin B12 levels can be used as predictive markers for the development of MF.

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Titel: Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience
verfasst von: Pınar Tığlıoğlu
Murat Albayrak
Abdulkerim Yıldız
Mesut Tığlıoğlu
Buğra Sağlam
Merih Reis Aras
Fatma Yılmaz
Senem Maral
Hacer Berna Afacan Öztürk
Ümit Yavuz Malkan
Publikationsdatum: 28.03.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Hematopathology / Ausgabe 2/2022
Print ISSN: 1868-9256
Elektronische ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-022-00488-6

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Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience

Abstract

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Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

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