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Erschienen in: Journal of Hematopathology 2/2022

28.03.2022 | Original Article

Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience

verfasst von: Pınar Tığlıoğlu, Murat Albayrak, Abdulkerim Yıldız, Mesut Tığlıoğlu, Buğra Sağlam, Merih Reis Aras, Fatma Yılmaz, Senem Maral, Hacer Berna Afacan Öztürk, Ümit Yavuz Malkan

Erschienen in: Journal of Hematopathology | Ausgabe 2/2022

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Abstract

In some patients with chronic myeloproliferative neoplasms, myelofibrosis (MF) develops as natural evolution of the disease. The aim of this study was to analyze predictive factors that may cause MF in polycythemia vera (PV) and essential thrombocythemia (ET) patients. This retrospective study was conducted on PV and ET patients who attended our hospital between 2008 and 2019. The development of MF during follow-up was recorded, and comparisons were made of the patients who developed MF and those who did not develop MF. Evaluation was made of 126 ET and 105 PV patients. During follow-up period, MF had developed 5.7% of PV and 7.1% of ET patients. It was determined that JAK-2 mutant allele burden, lymphocyte count, vitaminB12 levels, and grade of bone marrow fibrosis at diagnosis had statistically significant impact on the development of MF in all patients. In the logistic-regression analysis, it was found that initial hemoglobin, hematocrit, neutrophil-to-lymphocyte ratio, and monocyte count for PV patients; vitaminB12, the presence of splenomegaly; and BM fibrosis at diagnosis for ET patients have statistically significant effect on MF development. The results of the current study demonstrated that some parameters especially vitamin B12 levels can be used as predictive markers for the development of MF.
Literatur
1.
Zurück zum Zitat Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA et al (2007) Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood J Am Soc Hematol 110(4):1092–1097 Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA et al (2007) Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood J Am Soc Hematol 110(4):1092–1097
2.
Zurück zum Zitat Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405CrossRefPubMed Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405CrossRefPubMed
4.
Zurück zum Zitat Tefferi A (2003) The forgotten myeloproliferative disorder: myeloid metaplasia. Oncologist 8(3):225–231CrossRefPubMed Tefferi A (2003) The forgotten myeloproliferative disorder: myeloid metaplasia. Oncologist 8(3):225–231CrossRefPubMed
5.
Zurück zum Zitat Barosi G, Mesa RA, Thiele J, Cervantes F, Campbell PJ, Verstovsek S et al (2008) Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the International Working Group for Myelofibrosis Research and Treatment. Leukemia 22(2):437–438. https://doi.org/10.1038/sj.leu.2404914CrossRefPubMed Barosi G, Mesa RA, Thiele J, Cervantes F, Campbell PJ, Verstovsek S et al (2008) Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the International Working Group for Myelofibrosis Research and Treatment. Leukemia 22(2):437–438. https://​doi.​org/​10.​1038/​sj.​leu.​2404914CrossRefPubMed
10.
Zurück zum Zitat Boiocchi L, Mathew S, Gianelli U, Iurlo A, Radice T, Barouk-Fox S, et al. Morphologic and cytogenetic differences between post-polycythemic myelofibrosis and primary myelofibrosis in fibrotic stage. Modern Pathology: an official journal of the United States and Canadian Academy of Pathology, Inc. 2013;26(12):1577–85. https://doi.org/10.1038/modpathol.2013.109. Boiocchi L, Mathew S, Gianelli U, Iurlo A, Radice T, Barouk-Fox S, et al. Morphologic and cytogenetic differences between post-polycythemic myelofibrosis and primary myelofibrosis in fibrotic stage. Modern Pathology: an official journal of the United States and Canadian Academy of Pathology, Inc. 2013;26(12):1577–85. https://​doi.​org/​10.​1038/​modpathol.​2013.​109.
12.
Zurück zum Zitat Barbui T, Barosi G, Birgegard G, Cervantes F, Finazzi G, Griesshammer M et al (2011) Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 29(6):761CrossRefPubMedPubMedCentral Barbui T, Barosi G, Birgegard G, Cervantes F, Finazzi G, Griesshammer M et al (2011) Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 29(6):761CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Passamonti F, Rumi E, Pietra D, Elena C, Boveri E, Arcaini L et al (2010) A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications. Leukemia 24(9):1574–1579. https://doi.org/10.1038/leu.2010.148CrossRefPubMed Passamonti F, Rumi E, Pietra D, Elena C, Boveri E, Arcaini L et al (2010) A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications. Leukemia 24(9):1574–1579. https://​doi.​org/​10.​1038/​leu.​2010.​148CrossRefPubMed
26.
Zurück zum Zitat Kisseleva T, Brenner DA (2008) Mechanisms of fibrogenesis. Exp Biol Med 233(2):109–122CrossRef Kisseleva T, Brenner DA (2008) Mechanisms of fibrogenesis. Exp Biol Med 233(2):109–122CrossRef
28.
Zurück zum Zitat Barbui T, Thiele J, Passamonti F, Rumi E, Boveri E, Ruggeri M et al (2011) Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol: Official J Am Soc Clin Oncol 29(23):3179–3184. https://doi.org/10.1200/jco.2010.34.5298CrossRef Barbui T, Thiele J, Passamonti F, Rumi E, Boveri E, Ruggeri M et al (2011) Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol: Official J Am Soc Clin Oncol 29(23):3179–3184. https://​doi.​org/​10.​1200/​jco.​2010.​34.​5298CrossRef
30.
Zurück zum Zitat Gaman AM, Moisa C, Diaconu CC, Gaman MA (2019) Crosstalk between oxidative stress, chronic inflammation and disease progression in essential thrombocythemia. Rev Chim 70(10):3486–3489CrossRef Gaman AM, Moisa C, Diaconu CC, Gaman MA (2019) Crosstalk between oxidative stress, chronic inflammation and disease progression in essential thrombocythemia. Rev Chim 70(10):3486–3489CrossRef
31.
Zurück zum Zitat Ellis JT, Peterson P, Geller SA, Rappaport H (1986) Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies. Semin Hematol 23(2):144–155PubMed Ellis JT, Peterson P, Geller SA, Rappaport H (1986) Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies. Semin Hematol 23(2):144–155PubMed
33.
Zurück zum Zitat Georgii A, Buhr T, Buesche G, Kreft A, Choritz H (1996) Classification and staging of Ph-negative myeloproliferative disorders by histopathology from bone marrow biopsies. Leuk Lymphoma 22(sup1):15–29CrossRefPubMed Georgii A, Buhr T, Buesche G, Kreft A, Choritz H (1996) Classification and staging of Ph-negative myeloproliferative disorders by histopathology from bone marrow biopsies. Leuk Lymphoma 22(sup1):15–29CrossRefPubMed
34.
Zurück zum Zitat Guglielmelli P, Pacilli A, Rotunno G, Rumi E, Rosti V, Delaini F et al (2017) Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis. Blood J Am Soc Hematol 129(24):3227–3236 Guglielmelli P, Pacilli A, Rotunno G, Rumi E, Rosti V, Delaini F et al (2017) Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis. Blood J Am Soc Hematol 129(24):3227–3236
35.
Zurück zum Zitat Tefferi A (2013) Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol 88(2):141–150CrossRefPubMed Tefferi A (2013) Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol 88(2):141–150CrossRefPubMed
Metadaten
Titel
Analysis of factors associated with the development of myelofibrosis in polycythemia vera and essential thrombocythemia patients: a single-center experience
verfasst von
Pınar Tığlıoğlu
Murat Albayrak
Abdulkerim Yıldız
Mesut Tığlıoğlu
Buğra Sağlam
Merih Reis Aras
Fatma Yılmaz
Senem Maral
Hacer Berna Afacan Öztürk
Ümit Yavuz Malkan
Publikationsdatum
28.03.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Hematopathology / Ausgabe 2/2022
Print ISSN: 1868-9256
Elektronische ISSN: 1865-5785
DOI
https://doi.org/10.1007/s12308-022-00488-6

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