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Intensive Care Medicine

Erschienen in:

01.04.2008 | Editorial

ARDS and knowledge translation

verfasst von: Mingyao Liu

Erschienen in: Intensive Care Medicine | Ausgabe 4/2008

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Abstract

Knowledge translation is an important step for translational research. In this issue of Intensive Care Medicine, a new mini-series of basic research-related reviews is published. Three invited reviews focus on the role of extracellular matrix in ventilator-induced lung injury and mechanotransduction. The major challenges in the diagnosis and management of acute respiratory distress syndrome are discussed, which promote further awareness of knowledge translation in intensive care.

Gerlach H (2007) Mini-series: basic research-related reviews in intensive care medicine. Intensive Care Med 33:1–2PubMedCrossRef

Liu M (2005) Searching for acute respiratory distress syndrome genes: aren't we there yet? Am J Respir Crit Care Med 171:298–299PubMedCrossRef

dos Santos CC, Okutani D, Hu P, Han B, Crimi E, et al. (2007) Differential gene profiling in acute lung injury identifies injury specific gene expression. Crit Care Med DOI 10.1097/CCM.0B013E3181659333

Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, De Backer D, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Macrae D, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C (2007) Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS. Intensive Care Med 33:214–229PubMedCrossRef

Pelosi P, Rocco PR (2008) Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med DOI 10.1007/s00134-007-0964-9

Han B, Bai XH, Lodyga M, Xu J, Yang BB, Keshavjee S, Post M, Liu M (2004) Conversion of mechanical force into biochemical signaling. J Biol Chem 279:54793–54801PubMedCrossRef

Han B, Lodyga M, Liu M (2005) Ventilator-induced lung injury: role of protein–protein interaction in mechanosensation. Proc Am Thorac Soc 2:181–187PubMedCrossRef

Liu M, Tanswell AK, Post M (1999) Mechanical force-induced signal transduction in lung cells. Am J Physiol 277:L667–683PubMed

Mourgeon E, Xu J, Tanswell AK, Liu M, Post M (1999) Mechanical strain-induced posttranscriptional regulation of fibronectin production in fetal lung cells. Am J Physiol 277:L142–149PubMed

10.

Xu J, Liu M, Liu J, Caniggia I, Post M (1996) Mechanical strain induces constitutive and regulated secretion of glycosaminoglycans and proteoglycans in fetal lung cells. J Cell Sci 109(6):1605–1613PubMed

11.

Xu J, Liu M, Post M (1999) Differential regulation of extracellular matrix molecules by mechanical strain of fetal lung cells. Am J Physiol 276:L728–735PubMed

12.

Negrini D, Passi A, Moriondo A (2008) The role of proteoglycans in pulmonary edema development. Intensive Care Med DOI 10.1007/s00134-007-0962-y

13.

dos Santos CC (2008) Advances in mechanisms of repair and remodelling in acute lung injury. Intensive Care Med DOI 10.1007/s00134-007-0963-x

14.

Mura M, dos Santos CC, Stewart D, Liu M (2004) Vascular endothelial growth factor and related molecules in acute lung injury. J Appl Physiol 97:1605–1617PubMedCrossRef

15.

Andrade CF, Waddell TK, Keshavjee S, Liu M (2005) Innate immunity and organ transplantation: the potential role of toll-like receptors. Am J Transplant 5:969–975PubMedCrossRef

16.

Okutani D, Lodyga M, Han B, Liu M (2006) Src protein tyrosine kinase family and acute inflammatory responses. Am J Physiol Lung Cell Mol Physiol 291:L129–141PubMedCrossRef

Titel: ARDS and knowledge translation
verfasst von: Mingyao Liu
Publikationsdatum: 01.04.2008
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 4/2008
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0965-8

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