Erschienen in:
23.07.2021 | Original Contribution
Association of eating out frequency and other factors with serum uric acid levels and hyperuricemia in Chinese population
verfasst von:
Ningning Cui, Xiaokang Dong, Wei Liao, Yuan Xue, Xiaotian Liu, Xing Li, Jian Hou, Wenqian Huo, Linlin Li, Zhenxing Mao, Chongjian Wang, Yuqian Li
Erschienen in:
European Journal of Nutrition
|
Ausgabe 1/2022
Einloggen, um Zugang zu erhalten
Abstract
Purpose
A significant shift in meal pattern with frequent eating out was closely associated with multiple chronic outcomes, but with limited evidence on hyperuricemia. We aimed to explore the associations between eating out and serum uric acid (SUA) as well as hyperuricemia.
Methods
A total of 29,597 participants were recruited from the Henan Rural Cohort Study. A validated food frequency questionnaire (FFQ) was used to collect dietary data, including the frequency of eating out. Linear regression models were used to examine the association of eating-out frequency with SUA and BMI. Logistic regression and restricted cubic spline were performed to assess the association and dose–response relationship between eating-out frequency and hyperuricemia. The mediation effect of BMI between eating out and the risk of hyperuricemia was evaluated.
Results
Eating out was significantly associated with higher SUA levels in the total population and males (P < 0.001). Multivariate-adjusted odds ratios (ORs) with 95% confidence interval (CIs) of hyperuricemia were 1.26 (1.09, 1.46) for the total population and 1.18 (1.00, 1.40) for males (≥ 7 times/week vs 0 time/week). A non-linear positive dose–response relationship between eating-out frequency and hyperuricemia was observed. Furthermore, BMI played a partial mediating role in the relationship between eating out frequency and hyperuricemia, which explained 30.7% in the total population and 44.8% in males.
Conclusion
Our findings indicated that eating out was associated with increased SUA levels and elevated hyperuricemia risk in rural China, especially in males. Moreover, the relationship was partly mediated by BMI.
Clinical trials
ChiCTR-OOC-15006699 (2015-07-06).