Erschienen in:
01.06.2015 | Editorial
Balancing the “humors” in severe sepsis: still a role for extracorporeal therapies?
verfasst von:
Michael Darmon, Sean M. Bagshaw, Lui G. Forni
Erschienen in:
Intensive Care Medicine
|
Ausgabe 6/2015
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Excerpt
The mortality and morbidity from severe sepsis continue to be a major global health problem. Although the recent data from the Protocol-Based Care for Early Septic Shock (ProCESS) study showed a lower mortality in severe sepsis than had been demonstrated some 10 years previously, the mortality remains unacceptably high [
1,
2]. The pathogenesis of sepsis is complex, leading to the production of a wide range of inflammatory mediators, which propagate the host response to infection leading to the clinical syndrome of septic shock with multi-organ involvement. At present, treatment relies predominantly on source control, adequate early antimicrobials and organ support where necessary with little effective, targeted therapy [
3‐
5]. …