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Erschienen in: Der Gynäkologe 1/2009

01.01.2009 | Frauengesundheit in der Praxis

Blutungen während Schwangerschaft und Geburt

Schwangerschaftsbedingte hämostaseologische Veränderungen – Therapieempfehlungen

verfasst von: Dr. S. Hofer, B. Heindl, F.C. Meister, H. Maul, E. Martin, C. Sohn, M.A. Weigand

Erschienen in: Die Gynäkologie | Ausgabe 1/2009

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Zusammenfassung

Blutungen während der Schwangerschaft sind für Mutter und Kind vital bedrohlich und verlaufen oft fulminant. Sie sind für etwa 25% aller peripartalen maternalen Sterbefälle verantwortlich. Die besondere Pathophysiologie der schwangerschaftsbedingten hämostaseologischen Veränderungen, wie das erhöhte Gerinnungspotenzial, eine verminderte antikoagulatorische Aktivität und starke Alterationen des fibrinolytischen Systems müssen dem interdisziplinären Behandlungsteam bekannt sein, um eine zielgerichtete und konsequente Therapie durchführen zu können.
Zu den wichtigsten therapeutischen Eckpfeilern bei peripartalen Blutungen zählen neben der schnellen zielgerichteten interdisziplinären Therapie die kausale gynäkologischen Therapie, die frühzeitige Detektion und Durchbrechung einer Hyperfibrinolyse, die Optimierung von Fibrinogen und Thrombozyten als Endstrecke der Gerinnung und die Kenntnis der Möglichkeiten einer erweiterten Gerinnungstherapie.
Literatur
1.
Zurück zum Zitat Alkazaleh F, Geary M, Kingdom J et al. (2004) Elective non-removal of the placenta and prophylactic uterine artery embolization postpartum as a diagnostic imaging approach for the management of placenta percreta: a case report. J Obstet Gynaecol Can 26(8): 743–746PubMed Alkazaleh F, Geary M, Kingdom J et al. (2004) Elective non-removal of the placenta and prophylactic uterine artery embolization postpartum as a diagnostic imaging approach for the management of placenta percreta: a case report. J Obstet Gynaecol Can 26(8): 743–746PubMed
2.
Zurück zum Zitat American Society of Anesthesiologists Task Force on Obstetric Anesthesia (2007) Practice guidelines for obstetric anesthesia: an updated report by the american society of anesthesiologists task force on obstetric anesthesia. Anesthesiology 106(4): 843–863CrossRef American Society of Anesthesiologists Task Force on Obstetric Anesthesia (2007) Practice guidelines for obstetric anesthesia: an updated report by the american society of anesthesiologists task force on obstetric anesthesia. Anesthesiology 106(4): 843–863CrossRef
3.
Zurück zum Zitat Ananth CV, Savitz DA (1994) Vaginal bleeding and adverse reproductive outcomes: a meta-analysis. Paediatr Perinat Epidemiol 8(1): 62–78PubMedCrossRef Ananth CV, Savitz DA (1994) Vaginal bleeding and adverse reproductive outcomes: a meta-analysis. Paediatr Perinat Epidemiol 8(1): 62–78PubMedCrossRef
4.
Zurück zum Zitat Astermark J, Donfield SM, DiMichele DM et al. (2007) FENOC study group. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA novoseven comparative (FENOC) study. Blood 109(2): 546–551PubMedCrossRef Astermark J, Donfield SM, DiMichele DM et al. (2007) FENOC study group. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA novoseven comparative (FENOC) study. Blood 109(2): 546–551PubMedCrossRef
5.
Zurück zum Zitat Axelsen SM, Henriksen TB, Hedegaard M, Secher NJ (1995) Characteristics of vaginal bleeding during pregnancy. Eur J Obstet Gynecol Reprod Biol 63(2): 131–134PubMedCrossRef Axelsen SM, Henriksen TB, Hedegaard M, Secher NJ (1995) Characteristics of vaginal bleeding during pregnancy. Eur J Obstet Gynecol Reprod Biol 63(2): 131–134PubMedCrossRef
6.
Zurück zum Zitat Biron-Andreani C, Morau E, Schved JF (2003) Amniotic fluid embolism with haemostasis complications: primary fibrinogenolysis or disseminated intravascular coagulation? Pathophysiol Haemost Thromb 33(3): 170–171PubMedCrossRef Biron-Andreani C, Morau E, Schved JF (2003) Amniotic fluid embolism with haemostasis complications: primary fibrinogenolysis or disseminated intravascular coagulation? Pathophysiol Haemost Thromb 33(3): 170–171PubMedCrossRef
7.
Zurück zum Zitat Bonn C, Wetzka B, Zahradnik HP (2002) The use of TEG with the roTEG in preeclampsia and HELLP syndrome. Hypertens Pregnancy vol 21(suppl 1): 80 Bonn C, Wetzka B, Zahradnik HP (2002) The use of TEG with the roTEG in preeclampsia and HELLP syndrome. Hypertens Pregnancy vol 21(suppl 1): 80
8.
Zurück zum Zitat Bremme KA (2003) Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 16(2): 153–168 ReviewPubMedCrossRef Bremme KA (2003) Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 16(2): 153–168 ReviewPubMedCrossRef
9.
Zurück zum Zitat Butt K, Gagnon A, Delisle MF (2002) Failure of methotrexate and internal iliac balloon catheterization to manage placenta percreta. Obstet Gynecol 99(6): 981–982PubMedCrossRef Butt K, Gagnon A, Delisle MF (2002) Failure of methotrexate and internal iliac balloon catheterization to manage placenta percreta. Obstet Gynecol 99(6): 981–982PubMedCrossRef
10.
Zurück zum Zitat Catena C, Zingaro L, Casaccio D, Sechi LA (2000) Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance. Am J Med 109(7): 556–561PubMedCrossRef Catena C, Zingaro L, Casaccio D, Sechi LA (2000) Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance. Am J Med 109(7): 556–561PubMedCrossRef
11.
Zurück zum Zitat Charbit B, Mandelbrot L, Samain E et al. (2007) PPH Study group. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 5(2): 266–273PubMedCrossRef Charbit B, Mandelbrot L, Samain E et al. (2007) PPH Study group. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 5(2): 266–273PubMedCrossRef
12.
Zurück zum Zitat Chowdhury P, Saayman AG, Paulus U et al. (2004) Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 125(1): 69–73PubMedCrossRef Chowdhury P, Saayman AG, Paulus U et al. (2004) Efficacy of standard dose and 30  ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 125(1): 69–73PubMedCrossRef
13.
Zurück zum Zitat Clenney TL, Viera AJ (2004) Corticosteroids for HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome. BMJ 329(7460): 270–272 reviewPubMedCrossRef Clenney TL, Viera AJ (2004) Corticosteroids for HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome. BMJ 329(7460): 270–272 reviewPubMedCrossRef
14.
Zurück zum Zitat Collins PW (2003) Management of acquired haemophilia A--more questions than answers. Blood Coagul Fibrinolysis. 14(Suppl 1): S23–S27 review Collins PW (2003) Management of acquired haemophilia A--more questions than answers. Blood Coagul Fibrinolysis. 14(Suppl 1): S23–S27 review
15.
Zurück zum Zitat Crochetiere C (2003) Obstetric emergencies. Anesthesiol Clin North America 21(1): 111–125 ReviewPubMedCrossRef Crochetiere C (2003) Obstetric emergencies. Anesthesiol Clin North America 21(1): 111–125 ReviewPubMedCrossRef
16.
Zurück zum Zitat Deneux-Tharaux C, Carmona E, Bouvier-Colle MH, Bréart G (2006) Postpartum maternal mortality and cesarean delivery. Obste Gynecol 541 vol 108, no3 part1 Deneux-Tharaux C, Carmona E, Bouvier-Colle MH, Bréart G (2006) Postpartum maternal mortality and cesarean delivery. Obste Gynecol 541 vol 108, no3 part1
17.
Zurück zum Zitat Dildy GA (2002) Postpartum hemorrhage: new management options. Clin Obstet Gynecol 45(2): 330–344PubMedCrossRef Dildy GA (2002) Postpartum hemorrhage: new management options. Clin Obstet Gynecol 45(2): 330–344PubMedCrossRef
18.
Zurück zum Zitat Eder AF, Herron R, Strupp A et al. (2007) Transfusion-related acute lung injury surveillance (2003-2005) and the potential impact of the selective use of plasma from male donors in the american red cross. Transfusion 47(4): 599–607PubMedCrossRef Eder AF, Herron R, Strupp A et al. (2007) Transfusion-related acute lung injury surveillance (2003-2005) and the potential impact of the selective use of plasma from male donors in the american red cross. Transfusion 47(4): 599–607PubMedCrossRef
19.
Zurück zum Zitat FitzGerald MP, Floro C, Siegel J, Hernandez E (1996) Laboratory findings in hypertensive disorders of pregnancy. J Natl Med Assoc 88(12): 794–798PubMed FitzGerald MP, Floro C, Siegel J, Hernandez E (1996) Laboratory findings in hypertensive disorders of pregnancy. J Natl Med Assoc 88(12): 794–798PubMed
20.
Zurück zum Zitat Fonseca JE, Mendez F, Catano C, Arias F (2005) Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial. Am J Obstet Gynecol 193(5): 1591–1598PubMedCrossRef Fonseca JE, Mendez F, Catano C, Arias F (2005) Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial. Am J Obstet Gynecol 193(5): 1591–1598PubMedCrossRef
21.
Zurück zum Zitat Franchini M (2006) Postpartum acquired factor VIII inhibitors. Am J Hematol 81(10): 768–773PubMedCrossRef Franchini M (2006) Postpartum acquired factor VIII inhibitors. Am J Hematol 81(10): 768–773PubMedCrossRef
22.
Zurück zum Zitat Franchini M, Lippi G, Franchi M (2007) The use of recombinant activated factor VII in obstetric and gynaecological haemorrhage. BJOG 114(1): 8–15 reviewPubMedCrossRef Franchini M, Lippi G, Franchi M (2007) The use of recombinant activated factor VII in obstetric and gynaecological haemorrhage. BJOG 114(1): 8–15 reviewPubMedCrossRef
23.
Zurück zum Zitat Fuchs AR, Romero R, Keefe D et al. (1991) Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. Am J Obstet Gynecol 165: 1515–1523PubMed Fuchs AR, Romero R, Keefe D et al. (1991) Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. Am J Obstet Gynecol 165: 1515–1523PubMed
24.
Zurück zum Zitat Gai MY, Wu LF, Su QF, Tatsumoto K (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 112(2): 154–157PubMedCrossRef Gai MY, Wu LF, Su QF, Tatsumoto K (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 112(2): 154–157PubMedCrossRef
25.
Zurück zum Zitat Gerbasi FR, Bottoms S, Farag A, Mammen E (1990) Increased intravascular coagulation associated with pregnancy. Obstet Gynecol 75 (3 Pt 1): 385–389PubMed Gerbasi FR, Bottoms S, Farag A, Mammen E (1990) Increased intravascular coagulation associated with pregnancy. Obstet Gynecol 75 (3 Pt 1): 385–389PubMed
26.
Zurück zum Zitat Goldszmidt E, Davies S (2003) Two cases of hemorrhage secondary to amniotic fluid embolus managed with uterine artery embolization. Can J Anaesth 50(9): 917–921PubMed Goldszmidt E, Davies S (2003) Two cases of hemorrhage secondary to amniotic fluid embolus managed with uterine artery embolization. Can J Anaesth 50(9): 917–921PubMed
27.
Zurück zum Zitat Green D (2006) The management of acquired haemophilia. Haemophilia 12(Suppl 5): 32–36CrossRef Green D (2006) The management of acquired haemophilia. Haemophilia 12(Suppl 5): 32–36CrossRef
28.
Zurück zum Zitat Hansch E, Chitkara U, McAlpine J et al. (1999) Pelvic arterial embolization for control of obstetric hemorrhage:a five-year experience. Am J Obstet Gynecol 180: 1454–1460PubMedCrossRef Hansch E, Chitkara U, McAlpine J et al. (1999) Pelvic arterial embolization for control of obstetric hemorrhage:a five-year experience. Am J Obstet Gynecol 180: 1454–1460PubMedCrossRef
29.
Zurück zum Zitat Hardy JF, de Moerloose P, Samama CM (2006) Members of the groupe d’Interet en hemostase perioperatoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 53(suppl 6): S40–S58PubMedCrossRef Hardy JF, de Moerloose P, Samama CM (2006) Members of the groupe d’Interet en hemostase perioperatoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 53(suppl 6): S40–S58PubMedCrossRef
30.
Zurück zum Zitat Hatzopoulos FK (2005) Obstetric drug therapy. In: Koda-Kimble MA, Young LY, Kradjan WA et al. (eds) Applied therapeutics: the clinical use of drugs, 8th edn. Lippincott Williams & Wilkins, Philadelphia Hatzopoulos FK (2005) Obstetric drug therapy. In: Koda-Kimble MA, Young LY, Kradjan WA et al. (eds) Applied therapeutics: the clinical use of drugs, 8th edn. Lippincott Williams & Wilkins, Philadelphia
31.
Zurück zum Zitat Hay CR, Brown S, Collins PW et al. (2006) The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom haemophilia centre doctors organisation. Br J Haematol 133(6): 591–605PubMedCrossRef Hay CR, Brown S, Collins PW et al. (2006) The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom haemophilia centre doctors organisation. Br J Haematol 133(6): 591–605PubMedCrossRef
32.
Zurück zum Zitat Heilmann L, Wild C, Hojnacki B, Pollow K (2006) Successful treatment of life-threatening bleeding after cesarean section with recombinant activated factor VII. Clin Appl Thromb Hemost 12(2): 227–229PubMedCrossRef Heilmann L, Wild C, Hojnacki B, Pollow K (2006) Successful treatment of life-threatening bleeding after cesarean section with recombinant activated factor VII. Clin Appl Thromb Hemost 12(2): 227–229PubMedCrossRef
33.
Zurück zum Zitat Heindl B, Delorenzo C, Spannagl M (2005) High dose fibrinogen administration for acute therapy of coagulopathy during massive perioperative transfusion. Anaesthesist 54(8): 787–790PubMedCrossRef Heindl B, Delorenzo C, Spannagl M (2005) High dose fibrinogen administration for acute therapy of coagulopathy during massive perioperative transfusion. Anaesthesist 54(8): 787–790PubMedCrossRef
34.
Zurück zum Zitat Hellgren M (2003) Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 29(2): 125–130 ReviewPubMedCrossRef Hellgren M (2003) Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 29(2): 125–130 ReviewPubMedCrossRef
35.
Zurück zum Zitat Henrich W, Surbek D, Kainer F et al. (2008) Diagnosis and treatment of peripartum bleeding. J Perinat Med 10 Henrich W, Surbek D, Kainer F et al. (2008) Diagnosis and treatment of peripartum bleeding. J Perinat Med 10
36.
Zurück zum Zitat Henrich W, Fuchs I, Ehrenstein T et al. (2002) Antenatal diagnosis of placenta percreta with planned in situ retention and methotrexate therapy in a woman infected with HIV. Ultrasound Obstet Gynecol 20(1): 90–93PubMedCrossRef Henrich W, Fuchs I, Ehrenstein T et al. (2002) Antenatal diagnosis of placenta percreta with planned in situ retention and methotrexate therapy in a woman infected with HIV. Ultrasound Obstet Gynecol 20(1): 90–93PubMedCrossRef
37.
Zurück zum Zitat Holmes VA, Wallace JM (2005) Haemostasis in normal pregnancy: a balancing act? Biochem Soc Trans 33(Pt 2): 428–432 reviewPubMedCrossRef Holmes VA, Wallace JM (2005) Haemostasis in normal pregnancy: a balancing act? Biochem Soc Trans 33(Pt 2): 428–432 reviewPubMedCrossRef
38.
Zurück zum Zitat Holmes VA (2003) Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis? Proc Nutr Soc 62(2): 479–493 reviewPubMedCrossRef Holmes VA (2003) Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis? Proc Nutr Soc 62(2): 479–493 reviewPubMedCrossRef
39.
Zurück zum Zitat Huch A, Chaoui R (2004) Sectio caesarea: In: Schneider H, Husslein P, Schneider KTM (Hrsg) Die Geburtshilfe, 2. Aufl. Springer, Berlin Heidelberg New York Huch A, Chaoui R (2004) Sectio caesarea: In: Schneider H, Husslein P, Schneider KTM (Hrsg) Die Geburtshilfe, 2. Aufl. Springer, Berlin Heidelberg New York
40.
Zurück zum Zitat Innerhofer P, Fries D, Margreiter J et al. (2002) The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 95(4): 858–865PubMedCrossRef Innerhofer P, Fries D, Margreiter J et al. (2002) The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 95(4): 858–865PubMedCrossRef
41.
Zurück zum Zitat Kam PC, Thompson SA, Liew AC (2004) Thrombocytopenia in the parturient. Anaesthesia 59(3): 255–264 reviewPubMedCrossRef Kam PC, Thompson SA, Liew AC (2004) Thrombocytopenia in the parturient. Anaesthesia 59(3): 255–264 reviewPubMedCrossRef
42.
Zurück zum Zitat Karalapillai D, Popham P (2007) Recombinant factor VIIa in massive postpartum haemorrhage. Int J Obstet Anesth 16(1): 29–34PubMedCrossRef Karalapillai D, Popham P (2007) Recombinant factor VIIa in massive postpartum haemorrhage. Int J Obstet Anesth 16(1): 29–34PubMedCrossRef
43.
Zurück zum Zitat Kobayashi T, Terao T, Maki M, Ikenoue T (2001) Diagnosis and management of acute obstetrical DIC. Semin Thromb Hemost 27(2): 161–167 reviewPubMedCrossRef Kobayashi T, Terao T, Maki M, Ikenoue T (2001) Diagnosis and management of acute obstetrical DIC. Semin Thromb Hemost 27(2): 161–167 reviewPubMedCrossRef
44.
Zurück zum Zitat Koscielny J, von Tempelhoff GF, Ziemer S et al. (2004) A practical concept for preoperative management of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 10(2): 155–166PubMedCrossRef Koscielny J, von Tempelhoff GF, Ziemer S et al. (2004) A practical concept for preoperative management of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 10(2): 155–166PubMedCrossRef
45.
Zurück zum Zitat Kretzschmar M, Zahm DM, Rem ml er K et al. (2003) Anaphylactoid syndrome of pregnancy Pathophysiologische und therapeutische Aspekte der Fruchtwasserembolie (anaphylactoid syndrome of pregnancy) anhand einer Kasuistik mit letalem Ausgang. Anaesthesist 52(5): 419–426PubMedCrossRef Kretzschmar M, Zahm DM, Rem ml er K et al. (2003) Anaphylactoid syndrome of pregnancy Pathophysiologische und therapeutische Aspekte der Fruchtwasserembolie (anaphylactoid syndrome of pregnancy) anhand einer Kasuistik mit letalem Ausgang. Anaesthesist 52(5): 419–426PubMedCrossRef
46.
Zurück zum Zitat Krumnikl JJ, Böttiger BW, Strittmatter HJ, Motsch J (2002) Complete recovery after 2 h of cardiopulmonary resuscitation following high-dose prostaglandin treatment for atonic uterine haemorrhage. Acta Anaesthesiol Scand 46(9): 1168–1170PubMedCrossRef Krumnikl JJ, Böttiger BW, Strittmatter HJ, Motsch J (2002) Complete recovery after 2 h of cardiopulmonary resuscitation following high-dose prostaglandin treatment for atonic uterine haemorrhage. Acta Anaesthesiol Scand 46(9): 1168–1170PubMedCrossRef
47.
Zurück zum Zitat Ku DH, Arkel YS, Paidas MP, Lockwood CJ (2003) Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies. Thromb Haemost 90(6): 1074–1079PubMed Ku DH, Arkel YS, Paidas MP, Lockwood CJ (2003) Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies. Thromb Haemost 90(6): 1074–1079PubMed
48.
Zurück zum Zitat Letsky EA (2001) Disseminated intravascular coagulation. Best Pract Res Clin Obstet Gynaecol 15(4): 623–644 reviewPubMedCrossRef Letsky EA (2001) Disseminated intravascular coagulation. Best Pract Res Clin Obstet Gynaecol 15(4): 623–644 reviewPubMedCrossRef
49.
Zurück zum Zitat Lindoff C, Rybo G, Astedt B (1993) Treatment with tranexamic acid during pregnancy and the risk of thrombo-embolic complications. Thromb Haemost 70(2): 238–240PubMed Lindoff C, Rybo G, Astedt B (1993) Treatment with tranexamic acid during pregnancy and the risk of thrombo-embolic complications. Thromb Haemost 70(2): 238–240PubMed
50.
Zurück zum Zitat Lockwood CJ (2006) Pregnancy-associated changes in the hemostatic system. Clin Obstet Gynecol 49(4): 836–843PubMedCrossRef Lockwood CJ (2006) Pregnancy-associated changes in the hemostatic system. Clin Obstet Gynecol 49(4): 836–843PubMedCrossRef
51.
Zurück zum Zitat Maternal Mortality Update (2002) A focus on emergency obstetric care: United Nations Population Fund Maternal Mortality Update (2002) A focus on emergency obstetric care: United Nations Population Fund
52.
Zurück zum Zitat Ojala K, Perala J, Kariniemi J et al. (2005) Arterial embolization and prophylactic catheterization for the treatment for severe obstetric hemorrhage. Acta Obstet Gynecol Scand 84(11): 1075–1080PubMedCrossRef Ojala K, Perala J, Kariniemi J et al. (2005) Arterial embolization and prophylactic catheterization for the treatment for severe obstetric hemorrhage. Acta Obstet Gynecol Scand 84(11): 1075–1080PubMedCrossRef
53.
Zurück zum Zitat Orlikowski CEP, Rocke DA, Murray WB et al. (1996) Thromboelastographychanges in pre-eclampsia and eclampsia. Br J Anaesth 77: 157–161PubMed Orlikowski CEP, Rocke DA, Murray WB et al. (1996) Thromboelastographychanges in pre-eclampsia and eclampsia. Br J Anaesth 77: 157–161PubMed
54.
Zurück zum Zitat Parnas M, Sheiner E, Shoham-Vardi I et al. (2006) Moderate to severe thrombocytopenia during pregnancy. Eur J Obstet Gynecol Reprod Biol 128(1–2): 163–168 Parnas M, Sheiner E, Shoham-Vardi I et al. (2006) Moderate to severe thrombocytopenia during pregnancy. Eur J Obstet Gynecol Reprod Biol 128(1–2): 163–168
55.
Zurück zum Zitat Pelage JP, Le Dref O, Jacob D et al. (1999) Selective arterial embolization of the uterine arteries in the management of intractable post-partum hemorrhage. Acta Obstet Gynecol Scand 78: 698–703PubMedCrossRef Pelage JP, Le Dref O, Jacob D et al. (1999) Selective arterial embolization of the uterine arteries in the management of intractable post-partum hemorrhage. Acta Obstet Gynecol Scand 78: 698–703PubMedCrossRef
56.
Zurück zum Zitat Pfanner G, Kilgert K (2006) Geburtshilfliche Blutungskomplikationen Hämostaseologie 26(Suppl 1): S56–S63 Pfanner G, Kilgert K (2006) Geburtshilfliche Blutungskomplikationen Hämostaseologie 26(Suppl 1): S56–S63
57.
Zurück zum Zitat Poe MF (1959) Clot observation test for clinical diagnosis of clotting defects. Anesthesiology 20: 825–829PubMedCrossRef Poe MF (1959) Clot observation test for clinical diagnosis of clotting defects. Anesthesiology 20: 825–829PubMedCrossRef
58.
Zurück zum Zitat Prabu P, Parapia LA (2006) Bernard-Soulier syndrome in pregnancy. Clin Lab Haematol 28(3): 198–201PubMedCrossRef Prabu P, Parapia LA (2006) Bernard-Soulier syndrome in pregnancy. Clin Lab Haematol 28(3): 198–201PubMedCrossRef
59.
Zurück zum Zitat Ramanathan J, Bennett K (2003) Pre-eclampsia: fluids, drugs and anesthetic management. Anesthesiol Clin North America 21(1): 145–163PubMedCrossRef Ramanathan J, Bennett K (2003) Pre-eclampsia: fluids, drugs and anesthetic management. Anesthesiol Clin North America 21(1): 145–163PubMedCrossRef
60.
61.
Zurück zum Zitat Roberts HR, Monroe DM, Oliver JA et al. (1998) Newer concepts of blood coagulation. Haemophilia 4(4): 331–334PubMedCrossRef Roberts HR, Monroe DM, Oliver JA et al. (1998) Newer concepts of blood coagulation. Haemophilia 4(4): 331–334PubMedCrossRef
62.
Zurück zum Zitat Rouse DJ, MacPherson C, Landon M et al. (2006) National institute of child health and human development maternal-fetal medicine units network. Blood transfusion and cesarean delivery. Obstet Gynecol 108(4): 891–897PubMedCrossRef Rouse DJ, MacPherson C, Landon M et al. (2006) National institute of child health and human development maternal-fetal medicine units network. Blood transfusion and cesarean delivery. Obstet Gynecol 108(4): 891–897PubMedCrossRef
63.
Zurück zum Zitat Schuurmans N, Mackinnin C, Lane C et al. (2000) Prevention and management of postpartum haemorrhage: J Soc Obstetricians Gynaecologists Canada 88: 271–281 Schuurmans N, Mackinnin C, Lane C et al. (2000) Prevention and management of postpartum haemorrhage: J Soc Obstetricians Gynaecologists Canada 88: 271–281
64.
Zurück zum Zitat Segal S, Shemesh IY, Blumenthal R et al. (2003) Treatment of obstetric hemorrhage with recombinant activated factor VII (rFVIIa). Arch Gynecol Obstet 268(4): 266–267PubMedCrossRef Segal S, Shemesh IY, Blumenthal R et al. (2003) Treatment of obstetric hemorrhage with recombinant activated factor VII (rFVIIa). Arch Gynecol Obstet 268(4): 266–267PubMedCrossRef
65.
Zurück zum Zitat Shafi T, Jeha MT, Black L, Al Douri M (1997) Severe acquired haemophilia a treated with recombinant factor VIIa. Br J Haematol 98(4): 910–912PubMedCrossRef Shafi T, Jeha MT, Black L, Al Douri M (1997) Severe acquired haemophilia a treated with recombinant factor VIIa. Br J Haematol 98(4): 910–912PubMedCrossRef
66.
Zurück zum Zitat Sharma SK, Philip J, Whitten CW et al. (1999) Assessment of changes in coagulation in parturients with pre-eclampsia using thromboelastography. Anesthesiology 90: 3485–3490CrossRef Sharma SK, Philip J, Whitten CW et al. (1999) Assessment of changes in coagulation in parturients with pre-eclampsia using thromboelastography. Anesthesiology 90: 3485–3490CrossRef
67.
Zurück zum Zitat Silliman CC, Curtis BR, Kopko PM et al. (2007) Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood 109(4): 1752–1755PubMedCrossRef Silliman CC, Curtis BR, Kopko PM et al. (2007) Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood 109(4): 1752–1755PubMedCrossRef
68.
Zurück zum Zitat Smith JG, Merrill DC (2006) Oxytocin for induction of labor. Clin Obstet Gynecol 49: 594–608PubMedCrossRef Smith JG, Merrill DC (2006) Oxytocin for induction of labor. Clin Obstet Gynecol 49: 594–608PubMedCrossRef
69.
Zurück zum Zitat Sobieszczyk S, Breborowicz GH, Platicanov V et al. (2006) Recombinant factor VIIa in the management of postpartum bleeds: an audit of clinical use. Acta Obstet Gynecol Scand 85(10): 1239–1247 ReviewPubMedCrossRef Sobieszczyk S, Breborowicz GH, Platicanov V et al. (2006) Recombinant factor VIIa in the management of postpartum bleeds: an audit of clinical use. Acta Obstet Gynecol Scand 85(10): 1239–1247 ReviewPubMedCrossRef
70.
Zurück zum Zitat Teo SB, Kanagalingam D, Tan HK, Tan LK (2008) Massive postpartum haemorrhage after uterus-conserving surgery in placenta percreta: the danger of the partial placenta percreta. BJOG 115(6): 789–792PubMedCrossRef Teo SB, Kanagalingam D, Tan HK, Tan LK (2008) Massive postpartum haemorrhage after uterus-conserving surgery in placenta percreta: the danger of the partial placenta percreta. BJOG 115(6): 789–792PubMedCrossRef
71.
Zurück zum Zitat Toy P, Popovsky MA, Abraham E et al. (2005) National heart, lung and blood institute working group on TRALI. Transfusion-related acute lung injury: definition and review. Crit Care Med 33(4): 721–726 ReviewPubMedCrossRef Toy P, Popovsky MA, Abraham E et al. (2005) National heart, lung and blood institute working group on TRALI. Transfusion-related acute lung injury: definition and review. Crit Care Med 33(4): 721–726 ReviewPubMedCrossRef
72.
Zurück zum Zitat Vincent J-L, Rossaint R, Riou B et al. (2006) Recommendations on the use of recombinant activated factor VII as an adjunative treatment for massive bleeding: a european perspective. Crit Care 10: 1–12CrossRef Vincent J-L, Rossaint R, Riou B et al. (2006) Recommendations on the use of recombinant activated factor VII as an adjunative treatment for massive bleeding: a european perspective. Crit Care 10: 1–12CrossRef
73.
Zurück zum Zitat Weiner CP (1986) The obstetric patient and disseminated intravascular coagulation. Clin Perinatol 13(4): 705–717 reviewPubMed Weiner CP (1986) The obstetric patient and disseminated intravascular coagulation. Clin Perinatol 13(4): 705–717 reviewPubMed
74.
Zurück zum Zitat Whitta RK, Cox DJ, Mallett SV (1995) Thrombelastography reveals two causes of haemorrhage in HELLP syndrome. Br J Anaesth 74(4): 464–468PubMedCrossRef Whitta RK, Cox DJ, Mallett SV (1995) Thrombelastography reveals two causes of haemorrhage in HELLP syndrome. Br J Anaesth 74(4): 464–468PubMedCrossRef
75.
Zurück zum Zitat Xenakis EM, Piper JM (1997) Chemotherapeutic induction of labour. A rational approach. Drugs 54: 61–68PubMedCrossRef Xenakis EM, Piper JM (1997) Chemotherapeutic induction of labour. A rational approach. Drugs 54: 61–68PubMedCrossRef
76.
Zurück zum Zitat Yang J et al. (2005) Predictors of vaginal bleeding during the first two trimesters of pregnancy. Paediatr Perinat Epidemiol 19(4): 276–283PubMedCrossRef Yang J et al. (2005) Predictors of vaginal bleeding during the first two trimesters of pregnancy. Paediatr Perinat Epidemiol 19(4): 276–283PubMedCrossRef
77.
Zurück zum Zitat Zelop CM, Harlow BL, Frigoletto FD (1993) Emergency peripartum hysterectomy. Am J Obstet Gynecol 168: 1443–1448PubMed Zelop CM, Harlow BL, Frigoletto FD (1993) Emergency peripartum hysterectomy. Am J Obstet Gynecol 168: 1443–1448PubMed
Metadaten
Titel
Blutungen während Schwangerschaft und Geburt
Schwangerschaftsbedingte hämostaseologische Veränderungen – Therapieempfehlungen
verfasst von
Dr. S. Hofer
B. Heindl
F.C. Meister
H. Maul
E. Martin
C. Sohn
M.A. Weigand
Publikationsdatum
01.01.2009
Verlag
Springer-Verlag
Erschienen in
Die Gynäkologie / Ausgabe 1/2009
Print ISSN: 2731-7102
Elektronische ISSN: 2731-7110
DOI
https://doi.org/10.1007/s00129-008-2246-1

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