Erschienen in:
01.12.2010 | Original Paper
Brain proton magnetic spectroscopy in long-term treatment of Wilson’s disease patients
verfasst von:
Beata Tarnacka, Wojciech Szeszkowski, Marek Gołębiowski, Anna Członkowska
Erschienen in:
Metabolic Brain Disease
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Ausgabe 4/2010
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Abstract
We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson’s disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated 4 hWD patients, with no improvement and 8 with marked improvement; and 8 nWD patients with marked improvement and 7 with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.