Ausgabe 7/2023
Inhalt (48 Artikel)
Efficacy and safety of immune checkpoint inhibitors for hepatocellular carcinoma patients with macrovascular invasion or extrahepatic spread: a systematic review and meta-analysis of 54 studies with 6187 hepatocellular carcinoma patients
Cheng-Long Han, Bao-Wen Tian, Lun-Jie Yan, Zi-Niu Ding, Hui Liu, Xin-Cheng Mao, Jin-Cheng Tian, Jun-Shuai Xue, Si-Yu Tan, Zhao-Ru Dong, Yu-Chuan Yan, Jian-Guo Hong, Zhi-Qiang Chen, Dong-Xu Wang, Tao Li
Tumour microenvironment as a predictive factor for immunotherapy in non-muscle-invasive bladder cancer
Aleksandra Semeniuk-Wojtaś, Karolina Poddębniak-Strama, Magdalena Modzelewska, Maksymilian Baryła, Ewelina Dziąg-Dudek, Tomasz Syryło, Barbara Górnicka, Anna Jakieła, Rafał Stec
Multidisciplinary recommendations for essential baseline functional and laboratory tests to facilitate early diagnosis and management of immune-related adverse events among cancer patients
Berna C. Özdemir, Cristina Espinosa da Silva, Dimitri Arangalage, Pierre Monney, Sabina A. Guler, Uyen Huynh-Do, Guido Stirnimann, Lucia Possamai, Roman Trepp, Robert Hoepner, Anke Salmen, Camille L. Gerard, Petr Hruz, Lisa Christ, Sacha I. Rothschild
Correction to: Multidisciplinary recommendations for essential baseline functional and laboratory tests to facilitate early diagnosis and management of immune‑related adverse events among cancer patients
Berna C. Özdemir, Cristina Espinosa da Silva, Dimitri Arangalage, Pierre Monney, Sabina A. Guler, Uyen Huynh-Do, Guido Stirnimann, Lucia Possamai, Roman Trepp, Robert Hoepner, Anke Salmen, Camille L. Gerard, Petr Hruz, Lisa Christ, Sacha I. Rothschild
Association of medical comorbidities and cardiovascular disease with toxicity and survival among patients receiving checkpoint inhibitor immunotherapy
Andrew C. Johns, Mike Yang, Lai Wei, Madison Grogan, Sandipkumar H. Patel, Mingjia Li, Marium Husain, Kari L. Kendra, Gregory A. Otterson, Jarred T. Burkart, Daniel Spakowicz, Rebecca Hoyd, Dwight H. Owen, Carolyn J. Presley
The role of spatial interplay patterns between PD-L1-positive tumor cell and T cell in recurrence of locally advanced non-small cell lung cancer
Liying Yang, Wei Zhang, Jujie Sun, Guanqun Yang, Siqi Cai, Fenghao Sun, Ligang Xing, Xiaorong Sun
Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody
Noriyuki Nishiwaki, Kazuhiro Noma, Toshiaki Ohara, Tomoyoshi Kunitomo, Kento Kawasaki, Masaaki Akai, Teruki Kobayashi, Toru Narusaka, Hajime Kashima, Hiroaki Sato, Satoshi Komoto, Takuya Kato, Naoaki Maeda, Satoru Kikuchi, Shunsuke Tanabe, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Preliminary clinical study of personalized neoantigen vaccine therapy for microsatellite stability (MSS)-advanced colorectal cancer
Yao-Jun Yu, Na Shan, Li-Yi Li, Yue-Sheng Zhu, Li-Miao Lin, Chen-Chen Mao, Ting-Ting Hu, Xiang-Yang Xue, Xiao-Ping Su, Xian Shen, Zhen-Zhai Cai
Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma
Shuhei Yamada, Haruka Miyata, Makoto Isono, Kanta Hori, Junko Yanagawa, Aiko Murai, Tomoyuki Minowa, Yuka Mizue, Kenta Sasaki, Kenji Murata, Serina Tokita, Munehide Nakatsugawa, Sadahiro Iwabuchi, Shinichi Hashimoto, Terufumi Kubo, Takayuki Kanaseki, Tomohide Tsukahara, Takashige Abe, Nobuo Shinohara, Yoshihiko Hirohashi, Toshihiko Torigoe
Mean platelet volume, thrombocytosis, and survival in non-small cell lung cancer patients treated with first-line pembrolizumab alone or with chemotherapy
Mingjia Li, Songzhu Zhao, Gabrielle Lopez, Austin Secor, Parthib Das, Nitya Surya, Madison Grogan, Sandip Patel, Karthik Chakravarthy, Abdul Miah, Daniel Spakowicz, Gabriel Tinoco, Zihai Li, Lai Wei, Kai He, Erin Bertino, Asrar Alahmadi, Regan Memmott, Jacob Kaufman, Peter G. Shields, David P. Carbone, Carolyn J. Presley, Gregory A. Otterson, Dwight H. Owen
The 27-gene IO score is associated with efficacy of PD-1/L1 inhibitors independent of FGFR expression in a real-world metastatic urothelial carcinoma cohort
Tyler J. Nielsen, Matthew G. Varga, Catherine T. Cronister, Brian Z. Ring, Robert S. Seitz, Douglas T. Ross, Brock L. Schweitzer, Kimberly McGregor
Expression of soluble CD27 in extranodal natural killer/T-cell lymphoma, nasal type: potential as a biomarker for diagnosis and CD27/CD70-targeted therapy
Toshihiro Nagato, Hiroki Komatsuda, Ryusuke Hayashi, Miki Takahara, Kan Kishibe, Shunsuke Yasuda, Yuki Yajima, Akemi Kosaka, Takayuki Ohkuri, Kensuke Oikawa, Shohei Harabuchi, Michihisa Kono, Hidekiyo Yamaki, Risa Wakisaka, Yui Hirata-Nozaki, Kenzo Ohara, Takumi Kumai, Akihiro Katada, Tatsuya Hayashi, Yasuaki Harabuchi, Hiroya Kobayashi
Associations between KIR/KIR-ligand genotypes and clinical outcome for patients with advanced solid tumors receiving BEMPEG plus nivolumab combination therapy in the PIVOT-02 trial
A. S. Feils, A. K. Erbe, J. Birstler, K. Kim, U. Hoch, S. L. Currie, T. Nguyen, D. Yu, A. O. Siefker-Radtke, N. Tannir, S. M. Tolaney, A. Diab, P. M. Sondel
Alanine-based spacers promote an efficient antigen processing and presentation in neoantigen polypeptide vaccines
Carmen Aguilar-Gurrieri, Ana Barajas, Carla Rovirosa, Raquel Ortiz, Victor Urrea, Nuria de la Iglesia, Bonaventura Clotet, Julià Blanco, Jorge Carrillo
The role of blood cholesterol quality in patients with advanced cancer receiving immune checkpoint inhibitors
Fabiana Perrone, Elda Favari, Giuseppe Maglietta, Michela Verzè, Monica Pluchino, Roberta Minari, Roberto Sabato, Giulia Mazzaschi, Annalisa Ronca, Alessandra Rossi, Alessio Cortellini, Federica Pecci, Luca Cantini, Melissa Bersanelli, Federico Quaini, Marcello Tiseo, Sebastiano Buti
Effectiveness and tolerability of camrelizumab combined with molecular targeted therapy for patients with unresectable or advanced HCC
Ting Li, Jiang Guo, Yushen Liu, Zhaoqing Du, Zhaoyang Guo, Yangwei Fan, Long Cheng, Yue Zhang, Xu Gao, Yunyu Zhao, Xinyuan He, Wenhua Wu, Ning Gao, Yinying Wu, Jie Li, Yu Zhang, Wen Kang, Zhifang Cai, Wenjun Wang, Xiaopeng Li, Ying Zan, Mindie H. Nguyen, Fanpu Ji
Mitochondrial C1QBP is essential for T cell antitumor function by maintaining mitochondrial plasticity and metabolic fitness
Hui Tian, Dafei Chai, Gang Wang, Qiping Wang, Nan Sun, Guan Jiang, Huizhong Li, Jingyuan Song, Lin Fang, Meng Wang, Zengli Guo, Junnian Zheng
Risk factors indicating immune-related adverse events with combination chemotherapy with immune checkpoint inhibitors and platinum agents in patients with non-small cell lung cancer: a multicenter retrospective study
Airi Fujimoto, Yoshimichi Koutake, Daisuke Hisamatsu, Noriko Ookubo, Yurika Yabuuchi, Go Kamimura, Tatsuo Kai, Aki Kozono, Takahiro Ootsu, Hiroto Suzuki, Keisuke Matsuo, Kimiko Kuwahara, Yoshita Oiwane, Yuko Nagata, Kenya Tanimoto, Eri Sato, Mei Suenaga, Tomohiro Uehara, Akira Ikari, Satoshi Endo, Yoichi Hiraki, Yosei Kawamata
LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloid-derived suppressor cells
Peitao Wu, Yuhang Guo, Li Xiao, Jiaqi Yuan, Chao Tang, Jun Dong, Zhiyuan Qian
Correction to: LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloid-derived suppressor cells
Peitao Wu, Yuhang Guo, Li Xiao, Jiaqi Yuan, Chao Tang, Jun Dong, Zhiyuan Qian
Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study
Yunchao Wang, Xiaobo Yang, Yanyu Wang, Jingnan Xue, Nan Zhang, Xu Yang, Ning Cong, Junwei Zhang, Chengpei Zhu, Longhao Zhang, Xiaorong Hou, Haitao Zhao
Clinicopathological significance of peritumoral alveolar macrophages in patients with resected early-stage lung squamous cell carcinoma
Yu Tanaka, Tokiko Nakai, Ayako Suzuki, Yosuke Kagawa, Osamu Noritake, Tetsuro Taki, Hiroko Hashimoto, Tetsuya Sakai, Yuji Shibata, Hiroki Izumi, Kaname Nosaki, Hibiki Udagawa, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Saori Miyazaki, Naoya Sakamoto, Shingo Sakashita, Motohiro Kojima, Reiko Watanbe, Masahiro Tsuboi, Koichi Goto, Genichiro Ishii
Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Enrico Cortesi, Ernesto Rossi, Giovanni Schinzari, Giampaolo Tortora, Silverio Tomao, Giulia Fiscon, Lorenzo Farina, Simone Scagnoli, Simona Pisegna, Fabio Ciurluini, Antonella Chiavassa, Sasan Amirhassankhani, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Di Filippo, Ilaria Grazia Zizzari, Chiara Napoletano, Aurelia Rughetti, Marianna Nuti, Silvia Mezi, Paolo Marchetti
M2 tumor-associated macrophages resist to oxidative stress through heme oxygenase-1 in the colorectal cancer tumor microenvironment
Misato Ito, Kosaku Mimura, Shotaro Nakajima, Hirokazu Okayama, Katsuharu Saito, Takahiro Nakajima, Tomohiro Kikuchi, Hisashi Onozawa, Shotaro Fujita, Wataru Sakamoto, Motonobu Saito, Tomoyuki Momma, Zenichiro Saze, Koji Kono
MIP3α as an early prognostic predictor for patients with B-cell malignancies receiving CD19/CD22-redirected CAR-T cell cocktail therapy
Jin Jin, Tianjiao Liu, Jiali Cheng, Jiao Meng, Na Wang, Liang Huang, Xiaoxi Zhou, Liting Chen, Hui Luo, Jianfeng Zhou
Neoadjuvant Camrelizumab for Non-Small Cell Lung Cancer: A Retrospective Multicenter, Real-World Study (CTONG2004)
Si-Yang Liu, Qixun Chen, Chengzhi Zhou, Huizhong Zhang, Wen Li, Jianhua Chen, Jian Hu, Lin Wu, Qunqing Chen, Qiangsheng Dai, Jian-Zhen Shan, Fei Xu, Si-Yang Maggie Liu, Yi-Long Wu
A randomised controlled trial of long NY-ESO-1 peptide-pulsed autologous dendritic cells with or without alpha-galactosylceramide in high-risk melanoma
Nathaniel Dasyam, Katrina J. Sharples, Catherine Barrow, Ying Huang, Evelyn Bauer, Brigitta Mester, Catherine E. Wood, Astrid Authier-Hall, Marina Dzhelali, Tess Ostapowicz, Rajiv Kumar, Jessica Lowe, Alice Maxwell, Olivia K. Burn, Geoffrey M. Williams, Sarah E. Carley, Graham Caygill, Jeremy Jones, Susanna T. S. Chan, Victoria A. Hinder, Jerome Macapagal, Monica McCusker, Robert Weinkove, Margaret A. Brimble, Gavin F. Painter, Michael P. Findlay, P. Rod Dunbar, Olivier Gasser, Ian F. Hermans
Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation
Yun-Shan Lin, Shu-Fen Chiang, Chia-Yi Chen, Wei-Ze Hong, Tsung-Wei Chen, William Tzu-Liang Chen, Tao-Wei Ke, Pei-Chen Yang, Ji-An Liang, An‑Cheng Shiau, K. S. Clifford Chao, Kevin Chih-Yang Huang
Efficacy and safety of immune checkpoint inhibitors in elderly patients with primary liver cancer: a retrospective, multicenter, real-world cohort study
Lushan Xiao, Yanxia Liao, Jiaren Wang, Qimei Li, Hongbo Zhu, Chang Hong, Ruining Li, Jingzhe He, Hao Cui, Hanzhi Dong, Lin Zeng, Li Liu
HER2-targeting antibody–drug conjugate RC48 alone or in combination with immunotherapy for locally advanced or metastatic urothelial carcinoma: a multicenter, real-world study
Meiting Chen, Kai Yao, Manming Cao, Hao Liu, Cong Xue, Tao Qin, Lingru Meng, Zhousan Zheng, Zike Qin, Fangjian Zhou, Zhuowei Liu, Yanxia Shi, Xin An
CiTSA: a comprehensive platform provides experimentally supported signatures of cancer immunotherapy and analysis tools based on bulk and scRNA-seq data
Feng Li, Kejing Dong, Chunlong Zhang, Jingwen Wang, Yongjuan Tang, Ke Xue, Xuan Zheng, Kaiyue Song, Xiaomeng Zhang, Mengyue Li, Rui Zhao, Xiaoling Zhong, Yanjun Xu, Yunpeng Zhang, Xia Li
Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia
Jiali Cheng, Tong Ge, Xiaojian Zhu, Jue Wang, Yuhao Zeng, Wei Mu, Haodong Cai, Zhenyu Dai, Jin Jin, Yongkun Yang, Guang Hu, Xia Mao, Jianfeng Zhou, Li Zhu, Liang Huang
Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs
Fumihiro Fujiki, Soyoko Morimoto, Yuya Nishida, Satoe Tanii, Nao Aoyama, Miki Inatome, Kento Inoue, Akiko Katsuhara, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Shinji Sogo, Haruo Sugiyama
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
Liv Cecilie Vestrheim Thomsen, Alfred Honoré, Lars Anders Rokne Reisæter, Bjarte Almås, Astrid Børretzen, Svein Inge Helle, Kristina Førde, Einar Klæboe Kristoffersen, Silje Helland Kaada, Guro Kristin Melve, Torjan Magne Haslerud, Martin Biermann, Iris Bigalke, Gunnar Kvalheim, Waqas Azeem, Jan Roger Olsen, Benjamin Gabriel, Stian Knappskog, Ole Johan Halvorsen, Lars Andreas Akslen, Duke Bahn, Klaus Pantel, Sabine Riethdorf, Haakon Ragde, Bjørn Tore Gjertsen, Anne Margrete Øyan, Karl-Henning Kalland, Christian Beisland
Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire
Douglas G. Millar, S. Y. Cindy Yang, Azin Sayad, Qingchuan Zhao, Linh T. Nguyen, Kathrin Warner, Ami G. Sangster, Munehide Nakatsugawa, Kenji Murata, Ben X. Wang, Patricia Shaw, Blaise Clarke, Marcus Q. Bernardini, Trevor Pugh, Pierre Thibault, Naoto Hirano, Claude Perreault, Pamela S. Ohashi
IL13Rα2-targeted third-generation CAR-T cells with CD28 transmembrane domain mediate the best anti-glioblastoma efficacy
Aiqin Gu, Yue Bai, Can Zhang, Chang Xu, Zhijing An, Ying Zhang, Steven H. Zhong, Yi Hu, Xiaosong Zhong
Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and distant tumors
Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Rich, Ferry Ossendorp, Martine J. Jager
Integrative analyses of bulk and single-cell RNA-seq identified cancer-associated fibroblasts-related signature as a prognostic factor for immunotherapy in NSCLC
Shasha Wang, Guangyu Fan, Lin Li, Yajun He, Ning Lou, Tongji Xie, Liyuan Dai, Ruyun Gao, Mengwei Yang, Yuankai Shi, Xiaohong Han
First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid tumors
Johanna Bendell, Patricia LoRusso, Michael Overman, Anne M. Noonan, Dong-Wan Kim, John H. Strickler, Sang-We Kim, Stephen Clarke, Thomas J. George, Peter S. Grimison, Minal Barve, Manik Amin, Jayesh Desai, Trisha Wise-Draper, Steven Eck, Yu Jiang, Anis A. Khan, Yuling Wu, Philip Martin, Zachary A. Cooper, Nairouz Elgeioushi, Nancy Mueller, Rakesh Kumar, Sandip Pravin Patel
Factors impacting the efficacy of the in-situ vaccine with CpG and OX40 agonist
Alexander A. Pieper, Dan V. Spiegelman, Mildred A. R. Felder, Arika S. Feils, Noah W. Tsarovsky, Jen Zaborek, Zachary S. Morris, Amy K. Erbe, Alexander L. Rakhmilevich, Paul M. Sondel
Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models
Hiroyuki Takahashi, Nao Miyoshi, Hisashi Murakami, Yuta Okamura, Naohisa Ogo, Akimitsu Takagi, Daisuke Muraoka, Akira Asai
The landscape of objective response rate of anti-PD-1/L1 monotherapy across 31 types of cancer: a system review and novel biomarker investigating
Yize Mao, Hui Xie, Minyi Lv, Qiuxia Yang, Zeyu Shuang, Feng Gao, Shengping Li, Lina Zhu, Wei Wang
CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells
Anetta Marcinek, Bettina Brauchle, Lisa Rohrbacher, Gerulf Hänel, Nora Philipp, Florian Märkl, Thaddäus Strzalkowski, Sonja M. Lacher, Dragica Udiljak, Karsten Spiekermann, Sebastian Theurich, Sebastian Kobold, Roman Kischel, John R. James, Veit L. Bücklein, Marion Subklewe
Correction to: CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells
Anetta Marcinek, Bettina Brauchle, Lisa Rohrbacher, Gerulf Hänel, Nora Philipp, Florian Märkl, Thaddäus Strzalkowski, Sonja M. Lacher, Dragica Udiljak, Karsten Spiekermann, Sebastian Theurich, Sebastian Kobold, Roman Kischel, John R. James, Veit L. Bücklein, Marion Subklewe
Pembrolizumab near the end of life in patients with metastatic pancreatic cancer: a multi-site consecutive series to examine survival and patient treatment burden
Michael H. Storandt, Nguyen Tran, Nichole Martin, Aminah Jatoi
Anti-PD-1 therapy in advanced sarcomas: is cutaneous primary site a stronger predictor of response than histologic subtype?
Ruoyu Miao, Jennifer Swank, Dan Melzer, Steven Ludlow, Leah Clark, Molly Finger, Damon R. Reed, Mihaela Druta, Andrew S. Brohl
BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia
Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Alejandra Martínez-Pérez, Ana P. Gonzalez-Rodriguez, Ángel R. Payer, Esther González-García, Candelaria Aguilar-García, Sara González-Rodríguez, Alejandro López-Soto, Alejandra García-Torre, Segundo Gonzalez
Cancer immunity and immunotherapy beyond COVID-19
Matteo Bellone, Arianna Brevi, Vincenzo Bronte, Silvia Dusi, Pier Francesco Ferrucci, Paola Nisticò, Antonio Rosato, Vincenzo Russo, Antonio Sica, Gabriele Toietta, Mario Paolo Colombo