Ausgabe 8/2023
Inhalt (27 Artikel)
Nervous regulation: beta-2-adrenergic signaling in immune homeostasis, cancer immunotherapy, and autoimmune diseases
Sagarina Thapa, Xuefang Cao
BAP1-related signature predicts benefits from immunotherapy over VEGFR/mTOR inhibitors in ccRCC: a retrospective analysis of JAVELIN Renal 101 and checkmate-009/010/025 trials
Kan Liu, Yan Huang, Yu Xu, Guoqiang Wang, Shangli Cai, Xu Zhang, Taoping Shi
Cytotoxicity of CD19-CAR-NK92 cells is primarily mediated via perforin/granzyme pathway
Jonas Althaus, Verena Nilius-Eliliwi, Abdelouahid Maghnouj, Sascha Döring, Roland Schroers, Michael Hudecek, Stephan A. Hahn, Thomas Mika
Characteristic differences in the abundance of tumor-infiltrating lymphocytes and intratumoral developing T cells in thymoma, with special reference to PD-1 expression
Tatsuo Furuya, Shunta Ishihara, Hiroshi Ogi, Kyoko Masuda, Saya Shibata, Chiaki Nakazono, Satoru Okada, Masanori Shimomura, So Tando, Takeshi Yaoi, Yoshinobu Maeda, Masaaki Yamagishi, Hiroshi Kawamoto, Kyoko Itoh, Masayoshi Inoue
Engineered murine IL-21-secreting leukemia cells induce granzyme B+ T cells and CD4+CD44+CD62L− effector memory cells while suppressing regulatory T cells, leading to long-term survival
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Incidence of serious adverse events caused by tyrosine kinase inhibitor treatment following immune checkpoint inhibitor therapy in advanced NSCLC patients with oncogenic driver alterations
Yukiko Shimoda, Tatsuya Yoshida, Jun Miyakoshi, Masahiro Torasawa, Akiko Tateishi, Yuji Matsumoto, Ken Masuda, Yuki Shinno, Yusuke Okuma, Yasushi Goto, Hidehito Horinouchi, Noboru Yamamoto, Yuichiro Ohe
Switchable CAR T cell strategy against osteosarcoma
Laura Hidalgo, Beatriz Somovilla-Crespo, Patricia Garcia-Rodriguez, Alvaro Morales-Molina, Miguel Angel Rodriguez-Milla, Javier Garcia-Castro
The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms
Asuka Shibamiya, Yurie Miyamoto-Nagai, Shuhei Koide, Motohiko Oshima, Ola Rizq, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Rei Kato, Kensuke Kayamori, Yusuke Isshiki, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Yusuke Takeda, Ryo Koyama-Nasu, Tetsuhiro Chiba, Hiroaki Honda, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida, Naoya Mimura
Safety and efficacy of the anti-PD1 immunotherapy with nivolumab in trichoblastic carcinomas
E. Toulemonde, S. Chevret, M. Battistella, E. M. Neidhardt, C. Nardin, F. Le Du, N. Meyer, M. Véron, L. Gambotti, A. Lamrani-Ghaouti, P. Jamme, C. Chaffaut, M. De Pontville, E. Saada-Bouzid, M. Beylot-Barry, C. Simon, T. Jouary, A. Marabelle, L. Mortier
Characterizing the tumor immune microenvironment of ependymomas using targeted gene expression profiles and RNA sequencing
W. de Koning, F. F. Feenstra, F. G. J. Calkoen, J. van der Lugt, L. A. Kester, D. A. M. Mustafa
Massively recruited sTLR9+ neutrophils in rapidly formed nodules at the site of tumor cell inoculation and their contribution to a pro-tumor microenvironment
Mengyuan Kou, Wenting Lu, Mengru Zhu, Kuo Qu, Liying Wang, Yongli Yu
Phenotypic and functional analysis in HER2+ targeted therapy of human NK cell subpopulation according to the expression of FcεRIγ and NKG2C in breast cancer patients
María B. Bordignon, Ayelén I. Pesce Viglietti, Estefanía P. Juliá, María B. Sanchez, Alexander Rölle, Pablo Mandó, Luciana Sabatini, Alexis Ostinelli, Manglio M. Rizzo, María M. Barrio, José Mordoh, Leonardo Fainboim, Estrella M. Levy
Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma
Yongsheng Jiang, Lijie Han, Jian Yang, Minwei Yang, Jian Zhang, Meilin Xue, Youwei Zhu, Cheng Xiong, Minmin Shi, Shiwei Zhao, Baiyong Shen, Zhiwei Xu, Lingxi Jiang, Hao Chen
Cytokine profiling identifies circulating IL-6 and IL-15 as prognostic stratifiers in patients with non-small cell lung cancer receiving anti-PD-1/PD-L1 blockade therapy
Yusuke Inoue, Naoki Inui, Masato Karayama, Kazuhiro Asada, Masato Fujii, Shun Matsuura, Tomohiro Uto, Dai Hashimoto, Takashi Matsui, Masaki Ikeda, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Takafumi Suda
Phase I study of MSB2311, a novel pH-dependent anti-PD-L1 monoclonal antibody, treating patients with advanced solid tumors and lymphoma
Qi Zhang, Jian Zhang, Haijun Zhong, Ying Yuan, Lei Yang, Qingyuan Zhang, Dongmei Ji, Jifang Gong, Jing Li, Zhenling Yao, Chuan Qi, Jianming Wang, Lingmin Lu, Michael Shi, Xueming Qian, Lin Shen, Jian Li, Xichun Hu
Self-assembled nanoparticles based on DNA origami and a nitrated T helper cell epitope as a platform for the development of personalized cancer vaccines
Yanliang Kang, Wanli Zhang, Qiumin Yu, Le Gao, Jiale Quan, Fangling Gu, Yuxin Wu, Yahong Tian, Zijie Wu, Shishuai Shao, Hongyou Zhou, Shukang Duan, Yixiang Zhou, Li Zhang, Xiangdong Gao, Hong Tian, Wenbing Yao
Improved predictability of pancreatic ductal adenocarcinoma diagnosis using a blood immune cell biomarker panel developed from bulk mRNA sequencing and single-cell RNA-sequencing
Sung Ill Jang, Hyung Keun Lee, Eun-Ju Chang, Somi Kim, So Young Kim, In Young Hong, Jong Kyoung Kim, Hye Sun Lee, Juyeon Yang, Jae Hee Cho, Dong Ki Lee
Single-center phase 2 study of PD-1 inhibitor combined with DNA hypomethylation agent + CAG regimen in patients with relapsed/refractory acute myeloid leukemia
Xiao-Ning Gao, Yong-Feng Su, Meng-yue Li, Yu Jing, Jun Wang, Lei Xu, Lin-Lin Zhang, An Wang, Yi-Zhi Wang, Xuan Zheng, Yan-Fen Li, Dai-Hong Liu
Exploiting docetaxel-induced tumor cell necrosis with tumor targeted delivery of IL-12
S. Elizabeth Franks, Ginette S. Santiago-Sanchez, Kellsye P. Fabian, Kristen Solocinski, Paul L. Chariou, Duane H. Hamilton, Joshua T. Kowalczyk, Michelle R. Padget, Sofia R. Gameiro, Jeffrey Schlom, James W. Hodge
Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer
Hidekiyo Yamaki, Michihisa Kono, Risa Wakisaka, Hiroki Komatsuda, Takumi Kumai, Ryusuke Hayashi, Ryosuke Sato, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Tatsuya Hayashi, Hiroya Kobayashi, Akihiro Katada
Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology
Usman Y. Panni, Michael Y. Chen, Felicia Zhang, Darren R. Cullinan, Lijin Li, C. Alston James, Xiuli Zhang, S. Rogers, A. Alarcon, John M. Baer, Daoxiang Zhang, Feng Gao, Christopher A. Miller, Qingqing Gong, Kian-Huat Lim, David G. DeNardo, S. Peter Goedegebuure, William E. Gillanders, William G. Hawkins
Clinical roles of soluble PD-1 and PD-L1 in plasma of NSCLC patients treated with immune checkpoint inhibitors
Hidetomo Himuro, Yoshiro Nakahara, Yuka Igarashi, Taku Kouro, Naoko Higashijima, Norikazu Matsuo, Shuji Murakami, Feifei Wei, Shun Horaguchi, Kayoko Tsuji, Yasunobu Mano, Haruhiro Saito, Koichi Azuma, Tetsuro Sasada
Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma
Dennis Awuah, Megan Minnix, Enrico Caserta, Theophilus Tandoh, Vikram Adhikarla, Erasmus Poku, Russell Rockne, Flavia Pichiorri, John E. Shively, Xiuli Wang
Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides
Toon Stegmann, Anna-Sophia Wiekmeijer, Kitty Kwappenberg, Suzanne van Duikeren, Farien Bhoelan, Denzel Bemelman, Thomas J. M. Beenakker, Willem-Jan Krebber, Ramon Arens, Cornelis J. M. Melief
Immunoreactivity to WT1 peptide vaccine is associated with prognosis in elderly patients with acute myeloid leukemia: follow-up study of randomized phase II trial of OCV-501, an HLA class II-binding WT1 polypeptide
Tomoki Naoe, Akiko Saito, Nahoko Hosono, Senji Kasahara, Hideharu Muto, Kaoru Hatano, Mizuki Ogura, Taro Masunari, Masatsugu Tanaka, Kensuke Usuki, Yuichi Ishikawa, Koji Ando, Yukio Kondo, Yusuke Takagi, Satoru Takada, Maho Ishikawa, Ilseung Choi, Akihiro Sano, Hirokazu Nagai
Correction to: Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis
Guanfang Liu, Qi Zhang, Jingying Yang, Xiaomin Li, Luhua Xian, Wenmin Li, Ting Lin, Juan Cheng, Qiwen Lin, Xiuzhang Xu, Qin Li, Yu Lin, Maohua Zhou, Erxia Shen
Correction to: IL‑17A promotes fatty acid uptake through the IL‑17A/IL‑17RA/ p‑STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte‑rich microenvironment
Chunyan Yu, Xiulong Niu, Yongrui Du, Yan Chen, Xiaomei Liu, Lingling Xu, Yoichiro Iwakura, Xiaoxia Ma, Yan Li, Zhi Yao, Weimin Deng