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Journal of Cardiovascular Translational Research

Erschienen in:

01.08.2012

Cardiovascular Disease Risk in Young People with Type 1 Diabetes

verfasst von: Janet K. Snell-Bergeon, Kristen Nadeau

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2012

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Abstract

Cardiovascular disease (CVD) is the most frequent cause of death in people with type 1 diabetes (T1D), despite modern advances in glycemic control and CVD risk factor modification. CVD risk identification is essential in this high-risk population, yet remains poorly understood. This review discusses the risk factors for CVD in young people with T1D, including hyperglycemia, traditional CVD risk factors (dyslipidemia, smoking, physical activity, hypertension), as well as novel risk factors such as insulin resistance, inflammation, and hypoglycemia. We present evidence that adverse changes in cardiovascular function, arterial compliance, and atherosclerosis are present even during adolescence in people with T1D, highlighting the need for earlier intervention. The methods for investigating cardiovascular risk are discussed and reviewed. Finally, we discuss the observational studies and clinical trials which have thus far attempted to elucidate the best targets for early intervention in order to reduce the burden of CVD in people with T1D.

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Titel: Cardiovascular Disease Risk in Young People with Type 1 Diabetes
verfasst von: Janet K. Snell-Bergeon
Kristen Nadeau
Publikationsdatum: 01.08.2012
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 4/2012
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-012-9363-x

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