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12.07.2021 | Case Reports

Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report

verfasst von: Satoshi Nojima, Masaharu Kohara, Hiroshi Harada, Hitomi Kajikawa, Katsutoshi Hirose, Shin-Ichi Nakatsuka, Yukinobu Nakagawa, Kaori Oya, Yasuo Fukuda, Kazuhide Matsunaga, Narikazu Uzawa, Manabu Fujimoto, Satoru Toyosawa, Eiichi Morii

Erschienen in: Head and Neck Pathology | Ausgabe 2/2022

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Abstract

Clear cell carcinoma (CCC) is a rare epithelial malignant tumor of the salivary glands. It is characterized by tumor cells with clear cytoplasm, hyalinized stroma, and most importantly the fusion genes EWSR1-ATF1, EWSR1-CREM, and EWSR1-PLAG1. Break-apart FISH has been performed for multiple CCC cases, but direct sequencing analysis has been performed in relatively few. Herein, we report an interesting case of CCC harboring three EWSR1-ATF1 translocations: EWSR1 exon 8-ATF1 exon 4, EWSR1 exon 7-ATF1 exon 4, and EWSR1 exon 7-ATF1 exon 5. This case indicates the possibility of independent EWSR1-ATF1 gene translocations, and could provide insight into CCC tumorgenesis.

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Titel: Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report
verfasst von: Satoshi Nojima
Masaharu Kohara
Hiroshi Harada
Hitomi Kajikawa
Katsutoshi Hirose
Shin-Ichi Nakatsuka
Yukinobu Nakagawa
Kaori Oya
Yasuo Fukuda
Kazuhide Matsunaga
Narikazu Uzawa
Manabu Fujimoto
Satoru Toyosawa
Eiichi Morii
Publikationsdatum: 12.07.2021
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01356-y

Springer Medizin

Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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