Background
Materials and methods
Predicted functional residual capacity
EELV measured by the Capnodynamic method (EELVCO2)
Corrections
EELV measurement by computed tomography
Study protocol
Data analysis
Results
Demographics | N (46) |
---|---|
Gender (M/F) | 30 (66%)/15(33%) |
Age (years) | 68 ± 11 |
Weight (kg) | 80 ± 13 |
Height (cm) | 167 ± 9 |
PBW (kg) | 62 ± 10 |
BSA (m2) | 1.88 ± 0,17 |
BMI (kg/m2) | 28.7 ± 4.1 |
APACHE II | 17.4 ± 6.6 |
FRC pred (mL) | 2167 ± 386 |
Diagnosis | |
C-ARDS | 25 |
ARDS | 1 |
Pneumonia | 3 |
Hemoptysis (Lung Cancer) | 1 |
Septic shock | 5 |
Heart failure/Cardiac surgery | 7 |
Haemorrhagic shock | 1 |
Intoxication | 2 |
Encephalitis | 1 |
All Patients | Non-ARDS | ARDS | p value | |
N = 45 | N = 20 | N = 25 | ||
PaO2 (mmHg) | 93.6 ± 32.6 | 111.4 ± 39.2 | 80.8 ± 17.4 | < 0.001 |
FIO2 | 0.6 ± 0.2 | 0.5 ± 0.2 | 0.68 ± 0.21 | 0.004 |
PaO2/FIO2 | 177.8 ± 87.9 | 237.6 ± 81.4 | 132.3 ± 62.2 | < 0.001 |
SaO2 (%) | 96.8 ± 3.2 | 97.9 ± 3.0 | 95.9 ± 3.1 | < 0.04 |
PaCO2 (mmHg) | 47.8 ± 13.4 | 43.7 ± 10.1 | 51.1 ± 14.9 | 0.07 |
PACO2 (mmHg) | 34.1 ± 8.6 | 35.5 ± 7.6 | 32.9 ± 9.5 | 0.34 |
PETCO2 (mmHg) | 37.7 ± 9.6 | 37 ± 9 | 36.8 ± 10.2 | 0.78 |
VD/VTEnghoff | 0.54 ± 0.13 | 0.47 ± 0.13 | 0.58 ± 0.11 | < 0.007 |
VD/VTBohr | 0.34 ± 0.09 | 0.31 ± 0.07 | 0.36 ± 0.06 | 0.036 |
VCO2 (ml/min) | 240 ± 47 | 202 ± 46 | 220 ± 34 | 0.15 |
pHa | 7.40 ± 0.09 | 7.41 ± 0.08 | 7.39 ± 0.11 | 0.48 |
HCO3− (mmol/l) | 29.5 ± 6.5 | 27.6 ± 4.5 | 30.8 ± 6.5 | 0.11 |
Hb (gr/dl) | 9.6 ± 1.8 | 8.8 ± 1.3 | 10.3 ± 1.8 | 0.002 |
VT (ml) | 422 ± 87 | 427 ± 78 | 430 ± 89 | 0.89 |
VT/kg (ml/kg) | 6.9 ± 1.3 | 7 ± 1.1 | 7.1 ± 1.5 | 0.89 |
RR | 20.3 ± 3.5 | 19.7 ± 3.7 | 21.6 ± 2.6 | 0.03 |
VM (l/min) | 8.6 ± 1.8 | 7.9 ± 1.9 | 9.1 ± 1.7 | 0.04 |
VA (l/min) | 6.1 ± 1.2 | 5.8 ± 1.2 | 6.2 ± 1.2 | 0.58 |
Pplat (cmH2O) | 26.2 ± 3.7 | 25.8 ± 3.8 | 26.8 ± 3.5 | 0.20 |
PEEP (cmH2O) | 10.9 ± 2.9 | 11.4 ± 3 | 11.2 ± 3 | 0.41 |
PDriving (cmH2O) | 14.6 ± 4.6 | 13.8 ± 4.1 | 14.9 ± 4.9 | 0.07 |
Crs (ml/cmH2O) | 32.7 ± 14.2 | 34.3 ± 13.8 | 32.4 ± 15.9 | 0.97 |
EELVCT (ml) | 1335 ± 573 | 1440 ± 550 | 1215 ± 582 | 0.25 |
EELVCT funct (ml) | 1293 ± 585 | 1405 ± 554 | 1208 ± 527 | 0.17 |
EELVCO2 (ml) | 1620 ± 562 | 1640 ± 436 | 1605 ± 650 | 0.84 |
EELVCO2corr (ml) | 1296 ± 450 | 1312 ± 348 | 1275 ± 529 | 0.79 |
All Patients | Non-ARDS | ARDS | ||||
---|---|---|---|---|---|---|
Correlation R2/Bias (LoA) | Correlation R2/Bias (LoA) | Correlation R2/Bias (LoA) | ||||
EELVCT | EELVCT funct | EELVCT | EELVCT funct | EELVCT | EELVCT funct | |
EELVCO2 | 0.58/− 285 (513 to − 1083) | 0.59/− 327 (471 to − 1124) | 0.39/− 199 (667 to − 1067) | 0.39/− 235 (631 to − 1100) | 0.71/− 351 (380 to − 1082) | 0.69/− 387 (329 to − 1123) |
EELVCO2 corr | 0.58/− 39 (845 to − 863) | 0.59/− 2.75 (755 to − 761) | 0.45/128 (975 to − 719) | 0.45/93 (941 to − 754) | 0.71/− 41 (587 to − 668) | 0.73/− 86 (574 to − 746) |