Background
Methods
Experimental protocol
Primary and secondary end-points
Perioperative management
Anaesthetic technique
Surgery and cardiopulmonary bypass
Hemodynamic data
Intensive care unit management
Laboratory measurements
Statistical analysis
Results
Patient characteristics | Propofol (n = 37) | Sevoflurane (n = 36) |
---|---|---|
Preoperative data | ||
Age (yr) | 50.7 (6.6) | 50.5 (6.4) |
Weight (kg) | 54.5 (7.9) | 56.5 (11.8) |
Sex (M/F) | 18 / 19 | 16 / 20 |
ASA class | II–IV | II–IV |
EF (%) | 57.2 (5.6) | 55.9 (5.4) |
Types of surgery (n, %) | ||
Replacement of mitral valve | 15 (40) | 14 (39) |
Replacement of aortic valve | 9 (24) | 10 (28) |
Replacement of tricuspid valve | 4 (10) | 4 (11) |
Replacement of mitral valve and shaping of tricuspid valve | 9 (24) | 8 (22) |
Intraoperative data | ||
Operating time (min) | 198 (28) | 183 (34) |
CPB time (min) | 95 (18) | 96 (17) |
Aortic clamp time (min) | 62 (21) | 64 (18) |
Ratio of automatic heart beat recovery (%) | 62.2 | 83.3* |
Incidence of intraoperative awareness (%) | 0 | 0 |
Propofol (mg) | 857.3 (166.5) | 0 |
Sevoflurane (MAC hour) | 0 | 4.6 (0.9) |
Fentanyl (mg) | 2.0 (0.2) | 2.1 (0.3) |
Midazolam (mg) | 20.6 (2. 9) | 22.8 (3.0) |
Dopamine (mg) | 57.3 (13.5) | 45.9 (15.1)* |
Nitroglycerin (μg) | 130.3 (50.2) | 102.2 (34.5)* |
Epinephrine (μg) | 148.7 (37.8) | 111. 6 (19.6)* |
Postoperative data | ||
Duration of mechanical ventilation time (hr) | 9.4 (1.5) | 6.2 (0.8)* |
Serious complications or death (%) | 0 | 0 |
ICU stay (hr) | 48.6 (3.7) | 42.3 (3.5)* |
Hospital stay (d) | 16 (13–19) | 12 (9–15)* |
Parameter | Start of surgery | Pre-CPB | Post-CPB | End of surgery |
---|---|---|---|---|
MAP (mmHg) | ||||
Propofol | 82 (3) | 76 (5) | 68 (4)* | 71 (4)* |
Sevoflurane | 79 (4) | 77 (5) | 76 (3)#
| 80 (3)#
|
CVP (mmHg) | ||||
Propofol | 11 (3) | 12 (2) | 11 (3) | 12 (3) |
Sevoflurane | 12 (3) | 11 (3) | 12 (2) | 12 (2) |
Cardiac output (l/min) | ||||
Propofol | 5.7 (0.7) | 5.2 (0.8) | 4.6 (0.7)* | 4.7 (0.5)* |
Sevoflurane | 5.5 (0.8) | 5.4 (0.9) | 5.6 (0.6)#
| 5.4 (0.6)#
|
Marker | T0
| T1
| T2
| T3
| T4
|
---|---|---|---|---|---|
cTnI (ng/ml) | |||||
Propofol | 0.01 (0.02) | 18.26 (9.67)#
| 26.66 (9.10)#
| 13.71 (6.14)#
| 8.72 (4.83)#
|
Sevoflurane | 0.02 (0.02) | 10.17 (6.63)#*
| 15.17 (8.73)#*
| 9.00 (6.43)#*
| 4.62 (3.40)#*
|
CK-MB (u/l) | |||||
Propofol | 0.87 (0.50) | 47.73 (9.30)#
| 86.12 (7.50)#
| 31.79 (6.29)#
| 14.35 (4.31)#
|
Sevoflurane | 0.88 (0.60) | 28.54 (7.69)#*
| 61.29 (8.80)#*
| 20.60 (7.84)#*
| 8.28 (2.16)#*
|
IL-6 (pg/ml) | |||||
Propofol | 15.86 (4.45) | 36.89 (6.71)#
| 59.69 (7.53)#
| 25.80 (6.15)#
| 17.14 (5.17) |
Sevoflurane | 13.91 (5.00) | 27.87 (7.83)#*
| 42.67 (8.89)#*
| 22.64 (6.92)#
| 15.44 (4.54) |
IL-10 (pg/ml) | |||||
Propofol | 19.07 (4.75) | 56.72 (8.36)#
| 73.73 (7.44)#
| 28.35 (6.90)#
| 20.58 (7.56) |
Sevoflurane | 16.79 (4.74) | 38.24 (7.90)#*
| 54.29 (8.08)#*
| 23.70 (6.51)#
| 18.88 (5.50) |