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01.10.2014 | Urogenital

Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer

verfasst von: Cornelis G. van Niekerk, Jeroen A. W. M. van der Laak, Thomas Hambrock, Henk-Jan Huisman, J. Alfred Witjes, Jelle O. Barentsz, Christina A. Hulsbergen-van de Kaa

Erschienen in: European Radiology | Ausgabe 10/2014

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Abstract

Objectives

To correlate pharmacokinetic parameters of 3-T dynamic contrast-enhanced (DCE-)MRI with histopathologic microvascular and lymphatic parameters in organ-confined prostate cancer.

Methods

In 18 patients with unilateral peripheral zone (pT2a) tumours who underwent DCE-MRI prior to radical prostatectomy (RP), the following pharmacokinetic parameters were assessed: permeability surface area volume transfer constant (K ^trans), extravascular extracellular volume (Ve) and rate constant (K _ep). In the RP sections blood and lymph vessels were visualised immunohistochemically and automatically examined and analysed. Parameters assessed included microvessel density (MVD), area (MVA) and perimeter (MVP) as well as lymph vessel density (LVD), area (LVA) and perimeter (LVP).

Results

A negative correlation was found between age and K ^trans and K _ep for tumour (r = −0.60, p = 0.009; r = −0.67, p = 0.002) and normal (r = −0.54, p = 0.021; r = −0.46, p = 0.055) tissue. No correlation existed between absolute values of microvascular parameters from histopathology and DCE-MRI. In contrast, the ratio between tumour and normal tissue (correcting for individual microvascularity variations) significantly correlated between K _ep and MVD (r = 0.61, p = 0.007) and MVP (r = 0.54, p = 0.022). The lymphovascular parameters showed only a correlation between LVA and K _ep (r = −0.66, p = 0.003).

Conclusions

Significant correlations between DCE-MRI and histopathologic parameters were found when correcting for interpatient variations in microvascularity.

Key Points

• Normal prostate tissue shows strong heterogeneity in microvascularity.

• Peripheral zone prostate cancer shows increased and less heterogeneous microvascularity.

• Normal and tumour tissue shows considerable variation in microvascularity between patients.

• DCE-MRI should take into account the interprostatic heterogeneity of microvasculature between patients.

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Titel: Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer
verfasst von: Cornelis G. van Niekerk
Jeroen A. W. M. van der Laak
Thomas Hambrock
Henk-Jan Huisman
J. Alfred Witjes
Jelle O. Barentsz
Christina A. Hulsbergen-van de Kaa
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3301-z

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Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer