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19.02.2022 | COVID-19 | Chest Zur Zeit gratis

Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI

verfasst von: Cheng Wang, Haidong Li, Sa Xiao, Zimeng Li, Xiuchao Zhao, Junshuai Xie, Chaohui Ye, Liming Xia, Xin Lou, Xin Zhou

Erschienen in: European Radiology | Ausgabe 8/2022

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Abstract

Objectives

To visualize and quantitatively assess regional lung function of survivors of COVID-19 who were hospitalized using pulmonary free-breathing ¹H MRI.

Methods

A total of 12 healthy volunteers and 27 COVID-19 survivors (62.4 ± 8.1 days between infection and image acquisition) were recruited in this prospective study and performed chest ¹H MRI acquisitions with free tidal breathing. Then, conventional Fourier decomposition ventilation (FD-V) and global fractional ventilation (FV_Global) were analyzed. Besides, a modified PREFUL (mPREFUL) method was developed to adapt to COVID-19 survivors and generate dynamic ventilation maps and parameters. All the ventilation maps and parameters were analyzed using Student’s t-test. Pearson’s correlation and a Bland-Altman plot between FV_Global and mPREFUL were analyzed.

Results

There was no significant difference between COVID-19 and healthy groups regarding a static FD-V map (0.47 ± 0.12 vs 0.42 ± 0.08; p = .233). However, mPREFUL demonstrated lots of regional high ventilation areas (high ventilation percentage (HVP): 23.7% ± 10.6%) existed in survivors. This regional heterogeneity (i.e., HVP) in survivors was significantly higher than in healthy volunteers (p = .003). The survivors breathed deeper (flow-volume loop: 5375 ± 3978 vs 1688 ± 789; p = .005), and breathed more air in respiratory cycle (total amount: 62.6 ± 19.3 vs 37.3 ± 9.9; p < .001). Besides, mPREFUL showed both good Pearson’s correlation (r = 0.74; p < .001) and Bland-Altman consistency (mean bias = −0.01) with FV_Global.

Conclusions

Dynamic ventilation imaging using pulmonary free-breathing ¹H MRI found regional abnormity of dynamic ventilation function in COVID-19 survivors.

Key Points

• Pulmonary free-breathing¹H MRI was used to visualize and quantitatively assess regional lung ventilation function of COVID-19 survivors.

• Dynamic ventilation maps generated from ¹H MRI were more sensitive to distinguish the COVID-19 and healthy groups (total air amount: 62.6 ± 19.3 vs 37.3 ± 9.9; p < .001), compared with static ventilation maps (FD-V value: 0.47 ± 0.12 vs 0.42 ± 0.08; p = .233).

• COVID-19 survivors had larger regional heterogeneity (high ventilation percentage: 23.7% ± 10.6% vs 13.1% ± 7.9%; p = .003), and breathed deeper (flow-volume loop: 5375 ± 3978 vs 1688 ± 789; p = .005) than healthy volunteers.

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Titel: Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI
verfasst von: Cheng Wang
Haidong Li
Sa Xiao
Zimeng Li
Xiuchao Zhao
Junshuai Xie
Chaohui Ye
Liming Xia
Xin Lou
Xin Zhou
Publikationsdatum: 19.02.2022
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: European Radiology / Ausgabe 8/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-022-08605-w

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Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI