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Hepatology International
Erschienen in: Hepatology International 6/2020

13.11.2020 | Review Article

Current perspectives on the tumor microenvironment in hepatocellular carcinoma

verfasst von: Cositha Santhakumar, Edward J. Gane, Ken Liu, Geoffrey W. McCaughan

Erschienen in: Hepatology International | Ausgabe 6/2020

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Abstract

Hepatocellular carcinoma (HCC) is a heterogeneous inflammation-driven malignancy, which, despite significant advances in management, continues to portend a poor prognosis. Recent advances in basic and translational research have increasingly defined the role of the tumor microenvironment in the development and progression of HCC and facilitated the development of novel molecular targets. The hepatoma microenvironment is characterised by an immunosuppressive milieu of immune cells and tumor vasculature that is both structurally and functionally abnormal. Normalising the tumor microenvironment by adopting a multipronged approach that targets both carcinogenic processes and the immunosuppressive milieu has been supported by pre-clinical and clinical data. In this review, we summarise the current understanding of the hepatoma microenvironment, its influences and dynamic interactions with tumor cells, the vasculature and the gut. Finally, we discuss how manipulating the tumor microenvironment continues to shape the evolving landscape of HCC therapy.
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Metadaten
Titel
Current perspectives on the tumor microenvironment in hepatocellular carcinoma
verfasst von
Cositha Santhakumar
Edward J. Gane
Ken Liu
Geoffrey W. McCaughan
Publikationsdatum
13.11.2020
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 6/2020
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-020-10104-3

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