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Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
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Intensive Care Medicine
Erschienen in: Intensive Care Medicine 2/2022

15.12.2021 | Narrative Review

Current practice and evolving concepts in septic shock resuscitation

verfasst von: Jan Bakker, Eduardo Kattan, Djillali Annane, Ricardo Castro, Maurizio Cecconi, Daniel De Backer, Arnaldo Dubin, Laura Evans, Michelle Ng Gong, Olfa Hamzaoui, Can Ince, Bruno Levy, Xavier Monnet, Gustavo A. Ospina Tascón, Marlies Ostermann, Michael R. Pinsky, James A. Russell, Bernd Saugel, Thomas W. L. Scheeren, Jean-Louis Teboul, Antoine Vieillard Baron, Jean-Louis Vincent, Fernando G. Zampieri, Glenn Hernandez

Erschienen in: Intensive Care Medicine | Ausgabe 2/2022

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Abstract

Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.
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Literatur
1.
Menk M, Estenssoro E, Sahetya SK, Neto AS, Sinha P, Slutsky AS, Summers C, Yoshida T, Bein T, Ferguson ND (2020) Current and evolving standards of care for patients with ARDS. Intensive Care Med 46:2157–2167PubMedPubMedCentralCrossRef
2.
Vincent JL, Joosten A, Saugel B (2021) Hemodynamic monitoring and support. Crit Care Med 49:1638–1650PubMedCrossRef
3.
Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, McIntyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Moller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M (2021) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 47:1181–1247PubMedPubMedCentralCrossRef
4.
Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, Jaeschke R, Mebazaa A, Pinsky MR, Teboul JL, Vincent JL, Rhodes A (2014) Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 40:1795–1815PubMedPubMedCentralCrossRef
5.
Jansen TC, van Bommel J, Schoonderbeek FJ, Visser SJS, van der Klooster JM, Lima AP, Willemsen SP, Bakker J, Grp LS (2010) Early lactate-guided therapy in intensive care unit patients a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:752–761PubMedCrossRef
6.
Hernandez G, Bellomo R, Bakker J (2019) The ten pitfalls of lactate clearance in sepsis. Intensive Care Med 45:82–85PubMedCrossRef
7.
8.
9.
10.
Toscani L, Aya HD, Antonakaki D, Bastoni D, Watson X, Arulkumaran N, Rhodes A, Cecconi M (2017) What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis. Crit Care 21:207PubMedPubMedCentralCrossRef
11.
12.
13.
Hernandez G, Ospina-Tascon GA, Damiani LP, Estenssoro E, Dubin A, Hurtado J, Friedman G, Castro R, Alegria L, Teboul JL, Cecconi M, Ferri G, Jibaja M, Pairumani R, Fernandez P, Barahona D, Granda-Luna V, Cavalcanti AB, Bakker J, Investigators A-S, the Latin America Intensive Care N (2019) Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA 321:654–664PubMedPubMedCentralCrossRef
14.
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med 43:304–377PubMedCrossRef
15.
16.
Shi R, Monnet X, Teboul JL (2020) Parameters of fluid responsiveness. Curr Opin Crit Care 26:319–326PubMedCrossRef
17.
Vignon P, Repesse X, Begot E, Leger J, Jacob C, Bouferrache K, Slama M, Prat G, Vieillard-Baron A (2017) Comparison of echocardiographic indices used to predict fluid responsiveness in ventilated patients. Am J Respir Crit Care Med 195:1022–1032PubMedCrossRef
18.
Roger C, Zieleskiewicz L, Demattei C, Lakhal K, Piton G, Louart B, Constantin JM, Chabanne R, Faure JS, Mahjoub Y, Desmeulles I, Quintard H, Lefrant JY, Muller L, AzuRea G (2019) Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study. Crit Care 23:179PubMedPubMedCentralCrossRef
19.
Monnet X, Cipriani F, Camous L, Sentenac P, Dres M, Krastinova E, Anguel N, Richard C, Teboul JL (2016) The passive leg raising test to guide fluid removal in critically ill patients. Ann Intensive Care 6:46PubMedPubMedCentralCrossRef
20.
21.
Hernandez G, Teboul JL, Bakker J (2019) Norepinephrine in septic shock. Intensive Care Med 45:687–689PubMedCrossRef
22.
Feldheiser A, Gelman S, Chew M, Stopfkuchen-Evans M (2021) Vasopressor effects on venous return in septic patients: a review. Eur J Anaesthesiol 38:659–663PubMedCrossRef
23.
Innocenti F, Palmieri V, Tassinari I, Capretti E, De Paris A, Gianno A, Marchesini A, Montuori M, Pini R (2021) Change in myocardial contractility in response to treatment with norepinephrine in septic shock. Am J Respir Crit Care Med 204:365–368PubMedCrossRef
24.
Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC, Cecconi M, Chew MS, Cholley B, Cronhjort M, De Backer D, Dubin A, Dunser MW, Duranteau J, Gordon AC, Hajjar LA, Hamzaoui O, Hernandez G, Kanoore Edul V, Koster G, Landoni G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse RM, Pinsky MR, Radermacher P, Reuter DA, Sakr Y, Sander M, Saugel B, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vincent JL, van der Horst ICC, Vistisen ST, Teboul JL (2021) Current use of inotropes in circulatory shock. Ann Intensive Care 11:21PubMedPubMedCentralCrossRef
25.
Dubin A, Pozo MO, Casabella CA, Palizas F Jr, Murias G, Moseinco MC, Kanoore Edul VS, Palizas F, Estenssoro E, Ince C (2009) Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care 13:R92PubMedPubMedCentralCrossRef
26.
Patel BM, Chittock DR, Russell JA, Walley KR (2002) Beneficial effects of short-term vasopressin infusion during severe septic shock. Anesthesiology 96:576–582PubMedCrossRef
27.
Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887PubMedCrossRef
28.
Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, Pogson DG, Aya HD, Anjum A, Frazier GJ, Santhakumaran S, Ashby D, Brett SJ, Investigators V (2016) Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial. JAMA 316:509–518PubMedCrossRef
29.
Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC (2019) Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials. Intensive Care Med 45:844–855PubMedCrossRef
30.
Vincent JL, Post EH (2016) Sepsis: vasopressin: a first-line agent for septic shock? Nat Rev Nephrol 12:718–719PubMedCrossRef
31.
Dubin A, Henriquez E, Hernandez G (2018) Monitoring peripheral perfusion and microcirculation. Curr Opin Crit Care 24:173–180PubMedCrossRef
32.
Joly HR, Weil MH (1969) Temperature of the great toe as an indication of the severity of shock. Circulation 39:131–138PubMedCrossRef
33.
van Genderen ME, Engels N, van der Valk RJ, Lima A, Klijn E, Bakker J, van Bommel J (2015) Early peripheral perfusion-guided fluid therapy in patients with septic shock. Am J Respir Crit Care Med 191:477–480PubMedCrossRef
34.
Zampieri FG, Damiani LP, Bakker J, Ospina-Tascon GA, Castro R, Cavalcanti AB, Hernandez G, Investigators A-S, the Latin America Intensive Care N (2020) Effects of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels among patients with septic shock: a Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial. Am J Respir Crit Care Med 201:423–429PubMedCrossRef
35.
Zhou J, Song J, Gong S, Li L, Zhang H, Wang M (2017) Persistent hyperlactatemia-high central venous-arterial carbon dioxide to arterial-venous oxygen content ratio is associated with poor outcomes in early resuscitation of septic shock. Am J Emerg Med 35:1136–1141PubMedCrossRef
36.
Ospina-Tascon GA, Umana M, Bermudez WF, Bautista-Rincon DF, Valencia JD, Madrinan HJ, Hernandez G, Bruhn A, Arango-Davila C, De Backer D (2016) Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med 42:211–221PubMedCrossRef
37.
Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL, Cardiovascular Dynamics Section of the E (2018) Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. Intensive Care Med 44:281–299PubMedCrossRef
38.
Berthelsen RE, Ostrowski SR, Bestle MH, Johansson PI (2019) Co-administration of iloprost and eptifibatide in septic shock (CO-ILEPSS)-a randomised, controlled, double-blind investigator-initiated trial investigating safety and efficacy. Crit Care 23:301PubMedPubMedCentralCrossRef
39.
40.
Siam J, Kadan M, Flaishon R, Barnea O (2015) Blood flow versus hematocrit in optimization of oxygen transfer to tissue during fluid resuscitation. Cardiovasc Eng Technol 6:474–484PubMedCrossRef
41.
42.
Hilty MP, Akin S, Boerma C, Donati A, Erdem O, Giaccaglia P, Guerci P, Milstein DM, Montomoli J, Toraman F, Uz Z, Veenstra G, Ince C (2020) Automated algorithm analysis of sublingual microcirculation in an international multicentral database identifies alterations associated with disease and mechanism of resuscitation. Crit Care Med 48:e864–e875PubMedCrossRef
43.
Hilty MP, Guerci P, Ince Y, Toraman F, Ince C (2019) MicroTools enables automated quantification of capillary density and red blood cell velocity in handheld vital microscopy. Commun Biol 2:217PubMedPubMedCentralCrossRef
44.
Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL, Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW, Investigators S, the Pragmatic Critical Care Research G (2018) Balanced crystalloids versus saline in critically ill adults. N Engl J Med 378:829–839PubMedPubMedCentralCrossRef
45.
Jackson KE, Wang L, Casey JD, Bernard GR, Self WH, Rice TW, Semler MW, Investigators S, the Pragmatic Critical Care Research G (2021) Effect of early balanced crystalloids before ICU admission on sepsis outcomes. Chest 159:585–595PubMedCrossRef
46.
Jaynes MP, Murphy CV, Ali N, Krautwater A, Lehman A, Doepker BA (2018) Association between chloride content of intravenous fluids and acute kidney injury in critically ill medical patients with sepsis. J Crit Care 44:363–367PubMedCrossRef
47.
Zampieri FG, Machado FR, Biondi RS, Freitas FGR, Veiga VC, Figueiredo RC, Lovato WJ, Amendola CP, Serpa-Neto A, Paranhos JLR, Guedes MAV, Lucio EA, Oliveira-Junior LC, Lisboa TC, Lacerda FH, Maia IS, Grion CMC, Assuncao MSC, Manoel ALO, Silva-Junior JM, Duarte P, Soares RM, Miranda TA, de Lima LM, Gurgel RM, Paisani DM, Correa TD, Azevedo LCP, Kellum JA, Damiani LP, Brandao da Silva N, Cavalcanti AB, Si B, the Bm (2021) Effect of intravenous fluid treatment with a balanced solution vs 0.9% saline solution on mortality in critically ill patients: the BaSICS Randomized Clinical Trial. JAMA 326:1–12PubMedCentral
48.
49.
Colon Hidalgo D, Patel J, Masic D, Park D, Rech MA (2020) Delayed vasopressor initiation is associated with increased mortality in patients with septic shock. J Crit Care 55:145–148PubMedCrossRef
50.
Ospina-Tascon GA, Hernandez G, Alvarez I, Calderon-Tapia LE, Manzano-Nunez R, Sanchez-Ortiz AI, Quinones E, Ruiz-Yucuma JE, Aldana JL, Teboul JL, Cavalcanti AB, De Backer D, Bakker J (2020) Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis. Crit Care 24:52PubMedPubMedCentralCrossRef
51.
Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S (2019) Early use of norepinephrine in septic shock resuscitation (CENSER): a randomized trial. Am J Respir Crit Care Med 199:1097–1105PubMedCrossRef
52.
Li Y, Li H, Zhang D (2020) Timing of norepinephrine initiation in patients with septic shock: a systematic review and meta-analysis. Crit Care 24:488PubMedPubMedCentralCrossRef
53.
Silversides JA, Perner A, Malbrain M (2019) Liberal versus restrictive fluid therapy in critically ill patients. Intensive Care Med 45:1440–1442PubMedCrossRef
54.
Malbrain ML, Marik PE, Witters I, Cordemans C, Kirkpatrick AW, Roberts DJ, Van Regenmortel N (2014) Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice. Anaesthesiol Intensive Ther 46:361–380PubMedCrossRef
55.
Cordemans C, De Laet I, Van Regenmortel N, Schoonheydt K, Dits H, Martin G, Huber W, Malbrain ML (2012) Aiming for a negative fluid balance in patients with acute lung injury and increased intra-abdominal pressure: a pilot study looking at the effects of PAL-treatment. Ann Intensive Care 2(Suppl 1):S15PubMedPubMedCentralCrossRef
56.
Chawla LS, Davison DL, Brasha-Mitchell E, Koyner JL, Arthur JM, Shaw AD, Tumlin JA, Trevino SA, Kimmel PL, Seneff MG (2013) Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care 17:R207PubMedPubMedCentralCrossRef
57.
Hall A, Crichton S, Dixon A, Skorniakov I, Kellum JA, Ostermann M (2020) Fluid removal associates with better outcomes in critically ill patients receiving continuous renal replacement therapy: a cohort study. Crit Care 24:279PubMedPubMedCentralCrossRef
58.
Wang L, Qiu C, Guan X, Chen M, Chen J, Si X, Du Z, Liu Y, Ouyang B (2018) Fluid removal with ultrasound guided protocol improves the efficacy and safety of dehydration in post-resuscitated critically ill patients: a quasi-experimental, before and after study. Shock 50:401–407PubMedCrossRef
59.
Ospina-Tascon GA, Teboul JL, Hernandez G, Alvarez I, Sanchez-Ortiz AI, Calderon-Tapia LE, Manzano-Nunez R, Quinones E, Madrinan-Navia HJ, Ruiz JE, Aldana JL, Bakker J (2020) Diastolic shock index and clinical outcomes in patients with septic shock. Ann Intensive Care 10:41PubMedPubMedCentralCrossRef
60.
Sunagawa K, Maughan WL, Burkhoff D, Sagawa K (1983) Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol 245:H773-780PubMed
61.
Monge Garcia MI, Jian Z, Settels JJ, Hunley C, Cecconi M, Hatib F, Pinsky MR (2018) Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular systolic function during different experimental loading and contractile conditions. Crit Care 22:325PubMedPubMedCentralCrossRef
62.
Monge Garcia MI, Jian Z, Hatib F, Settels JJ, Cecconi M, Pinsky MR (2020) Dynamic arterial elastance as a ventriculo-arterial coupling index: an experimental animal study. Front Physiol 11:284PubMedPubMedCentralCrossRef
63.
Garcia MI, Romero MG, Cano AG, Aya HD, Rhodes A, Grounds RM, Cecconi M (2014) Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study. Crit Care 18:626PubMedPubMedCentralCrossRef
64.
Guinot PG, Bernard E, Levrard M, Dupont H, Lorne E (2015) Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing norepinephrine dosage in septic shock. Crit Care 19:14PubMedPubMedCentralCrossRef
65.
Persichini R, Silva S, Teboul JL, Jozwiak M, Chemla D, Richard C, Monnet X (2012) Effects of norepinephrine on mean systemic pressure and venous return in human septic shock. Crit Care Med 40:3146–3153PubMedCrossRef
66.
Fiorese Coimbra KT, de Freitas FGR, Bafi AT, Pinheiro TT, Nunes NF, de Azevedo LCP, Machado FR (2019) Effect of increasing blood pressure with noradrenaline on the microcirculation of patients with septic shock and previous arterial hypertension. Crit Care Med 47:1033–1040PubMedCrossRef
67.
Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Herve F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P, Investigators S (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:1583–1593PubMedCrossRef
68.
Lamontagne F, Richards-Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, Camsooksai J, Darnell R, Gordon AC, Henry D, Hudson N, Mason AJ, Saull M, Whitman C, Young JD, Rowan KM, Mouncey PR, trial i (2020) Effect of reduced exposure to vasopressors on 90-day mortality in older critically ill patients with vasodilatory hypotension: a randomized clinical trial. JAMA 323:938–949PubMedPubMedCentralCrossRef
69.
Liu ZM, Chen J, Kou Q, Lin Q, Huang X, Tang Z, Kang Y, Li K, Zhou L, Song Q, Sun T, Zhao L, Wang X, He X, Wang C, Wu B, Lin J, Yuan S, Gu Q, Qian K, Shi X, Feng Y, Lin A, He X, Study Group of i, Guan XD (2018) Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial. Intensive Care Med 44:1816–1825PubMedCrossRef
70.
Russell JA, Vincent JL, Kjolbye AL, Olsson H, Blemings A, Spapen H, Carl P, Laterre PF, Grundemar L (2017) Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care 21:213PubMedPubMedCentralCrossRef
71.
Laterre PF, Berry SM, Blemings A, Carlsen JE, Francois B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windelov NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brule N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjolbye AL, Angus DC, Investigators S-A (2019) Effect of selepressin vs placebo on ventilator- and vasopressor-free days in patients with septic shock: the SEPSIS-ACT randomized clinical trial. JAMA 322:1476–1485PubMedPubMedCentralCrossRef
72.
Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, Busse LW, Altaweel L, Albertson TE, Mackey C, McCurdy MT, Boldt DW, Chock S, Young PJ, Krell K, Wunderink RG, Ostermann M, Murugan R, Gong MN, Panwar R, Hastbacka J, Favory R, Venkatesh B, Thompson BT, Bellomo R, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Deane AM, Investigators A (2017) Angiotensin II for the treatment of vasodilatory shock. N Engl J Med 377:419–430PubMedCrossRef
73.
Bellomo R, Forni LG, Busse LW, McCurdy MT, Ham KR, Boldt DW, Hastbacka J, Khanna AK, Albertson TE, Tumlin J, Storey K, Handisides D, Tidmarsh GF, Chawla LS, Ostermann M (2020) Renin and survival in patients given angiotensin II for catecholamine-resistant vasodilatory shock. a clinical trial. Am J Respir Crit Care Med 202:1253–1261PubMedPubMedCentralCrossRef
74.
Tumlin JA, Murugan R, Deane AM, Ostermann M, Busse LW, Ham KR, Kashani K, Szerlip HM, Prowle JR, Bihorac A, Finkel KW, Zarbock A, Forni LG, Lynch SJ, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Bellomo R, Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Investigators (2018) Outcomes in patients with vasodilatory shock and renal replacement therapy treated with intravenous angiotensin II. Crit Care Med 46:949–957PubMedPubMedCentralCrossRef
75.
Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjornsson B, Nedashkovsky EV, Bjertnaes LJ (2001) Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study. Crit Care Med 29:1860–1867PubMedCrossRef
76.
Memis D, Karamanlioglu B, Yuksel M, Gemlik I, Pamukcu Z (2002) The influence of methylene blue infusion on cytokine levels during severe sepsis. Anaesth Intensive Care 30:755–762PubMedCrossRef
77.
78.
Geri G, Vignon P, Aubry A, Fedou AL, Charron C, Silva S, Repesse X, Vieillard-Baron A (2019) Cardiovascular clusters in septic shock combining clinical and echocardiographic parameters: a post hoc analysis. Intensive Care Med 45:657–667PubMedCrossRef
79.
Vieillard-Baron A, Caille V, Charron C, Belliard G, Page B, Jardin F (2008) Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 36:1701–1706PubMedCrossRef
80.
Belletti A, Benedetto U, Biondi-Zoccai G, Leggieri C, Silvani P, Angelini GD, Zangrillo A, Landoni G (2017) The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials. J Crit Care 37:91–98PubMedCrossRef
81.
De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL (2006) The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34:403–408PubMedCrossRef
82.
Vincent JL, Roman A, De Backer D, Kahn RJ (1990) Oxygen uptake/supply dependency. Effects of short-term dobutamine infusion. Am J Respir Crit Care Med 142:2–7
83.
84.
Potter EK, Hodgson L, Creagh-Brown B, Forni LG (2019) Manipulating the microcirculation in sepsis—the impact of vasoactive medications on microcirculatory blood flow: a systematic review. Shock 52:5–12PubMedCrossRef
85.
Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu KD, Ashby D (2016) Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 375:1638–1648PubMedCrossRef
86.
Bhattacharjee S, Soni KD, Maitra S, Baidya DK (2017) Levosimendan does not provide mortality benefit over dobutamine in adult patients with septic shock: a meta-analysis of randomized controlled trials. J Clin Anesth 39:67–72PubMedCrossRef
87.
Einav S, Helviz Y, Ippolito M, Cortegiani A (2021) Vasopressor and inotrope treatment for septic shock: an umbrella review of reviews. J Crit Care 65:65–71PubMedCrossRef
88.
Hernandez G, Tapia P, Alegria L, Soto D, Luengo C, Gomez J, Jarufe N, Achurra P, Rebolledo R, Bruhn A, Castro R, Kattan E, Ospina-Tascon G, Bakker J (2016) Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock. Crit Care 20:234PubMedPubMedCentralCrossRef
89.
Stolk RF, van der Poll T, Angus DC, van der Hoeven JG, Pickkers P, Kox M (2016) Potentially inadvertent immunomodulation: norepinephrine use in sepsis. Am J Respir Crit Care Med 194:550–558PubMedCrossRef
90.
Miyamoto K, Nakashima T, Shima N, Kato S, Ueda K, Kawazoe Y, Ohta Y, Morimoto T, Yamamura H, on behalf of DTI (2018) Effect of dexmedetomidine on lactate clearance in patients with septic shock: a subanalysis of a multicenter randomized controlled trial. Shock 50:162–166PubMedCrossRef
91.
Morelli A, Sanfilippo F, Arnemann P, Hessler M, Kampmeier TG, D’Egidio A, Orecchioni A, Santonocito C, Frati G, Greco E, Westphal M, Rehberg SW, Ertmer C (2018) The effect of propofol and dexmedetomidine sedation on norepinephrine requirements in septic shock patients: a crossover trial. Crit Care Med 47:e89–e95CrossRef
92.
Cioccari L, Luethi N, Bailey M, Shehabi Y, Howe B, Messmer AS, Proimos HK, Peck L, Young H, Eastwood GM, Merz TM, Takala J, Jakob SM, Bellomo R, Group ACT, the SIIII (2020) The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial. Crit Care 24:441PubMedPubMedCentralCrossRef
93.
Levy B, Fritz C, Piona C, Duarte K, Morelli A, Guerci P, Kimmoun A, Girerd N (2021) Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study. Crit Care 25:21PubMedPubMedCentralCrossRef
94.
Morelli A, Romano SM, Sanfilippo F, Santonocito C, Frati G, Chiostri M, Agro FE, Ertmer C, Rehberg SW, Vieillard-Baron A (2020) Systolic-dicrotic notch pressure difference can identify tachycardic patients with septic shock at risk of cardiovascular decompensation following pharmacological heart rate reduction. Br J Anaesth 125:1018–1024PubMedCrossRef
95.
96.
Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R, Investigators VT (2020) Effect of Vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA 323:423–431PubMedPubMedCentralCrossRef
97.
Chang P, Liao Y, Guan J, Guo Y, Zhao M, Hu J, Zhou J, Wang H, Cen Z, Tang Y, Liu Z (2020) Combined treatment with hydrocortisone, Vitamin C, and thiamine for sepsis and septic shock: a randomized controlled trial. Chest 158:174–182PubMedCrossRef
98.
Annane D, Ouanes-Besbes L, de Backer D, Du B, Gordon AC, Hernandez G, Olsen KM, Osborn TM, Peake S, Russell JA, Cavazzoni SZ (2018) A global perspective on vasoactive agents in shock. Intensive Care Med 44:833–846PubMedCrossRef
99.
Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Lindsell CJ (2018) Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Crit Care Med 46:e242–e249PubMedPubMedCentralCrossRef
100.
Anantasit N, Boyd JH, Walley KR, Russell JA (2014) Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock. Crit Care Med 42:1812–1820PubMedCrossRef
101.
Ounissi M, Benkirane A, Dempsey E, Soares R, Jullien V, Pons G, Chhun S (2015) A review of potential pharmacogenetic effects on catecholamine responses. Drug Metab Rev 47:558–564PubMedCrossRef
102.
Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, Palevsky PM, Weisberg LS, Schorr CA, Trzeciak S, Walker PM, Investigators ET (2018) Effect of targeted Polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level: the EUPHRATES randomized clinical trial. JAMA 320:1455–1463PubMedPubMedCentralCrossRef
103.
Schadler D, Pausch C, Heise D, Meier-Hellmann A, Brederlau J, Weiler N, Marx G, Putensen C, Spies C, Jorres A, Quintel M, Engel C, Kellum JA, Kuhlmann MK (2017) The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: a randomized controlled trial. PLoS One 12:e0187015PubMedPubMedCentralCrossRef
104.
Atan R, Peck L, Prowle J, Licari E, Eastwood GM, Storr M, Goehl H, Bellomo R (2018) A double-blind randomized controlled trial of high cutoff versus standard hemofiltration in critically ill patients with acute kidney injury. Crit Care Med 46:e988–e994PubMedCrossRef
105.
Joannes-Boyau O, Honore PM, Perez P, Bagshaw SM, Grand H, Canivet JL, Dewitte A, Flamens C, Pujol W, Grandoulier AS, Fleureau C, Jacobs R, Broux C, Floch H, Branchard O, Franck S, Roze H, Collin V, Boer W, Calderon J, Gauche B, Spapen HD, Janvier G, Ouattara A (2013) High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med 39:1535–1546PubMedCrossRef
106.
Lipcsey M, Tenhunen J, Pischke SE, Kuitunen A, Flaatten H, De Geer L, Sjolin J, Frithiof R, Chew MS, Bendel S, Kawati R, Larsson A, Mollnes TE, Tonnessen TI, Rubertsson S (2020) Endotoxin removal in septic shock with the alteco LPS adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial-the asset study. Shock 54:224–231PubMedCrossRef
107.
Busund R, Koukline V, Utrobin U, Nedashkovsky E (2002) Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial. Intensive Care Med 28:1434–1439PubMedCrossRef
108.
Tumlin JA, Galphin CM, Tolwani AJ, Chan MR, Vijayan A, Finkel K, Szamosfalvi B, Dev D, DaSilva JR, Astor BC, Yevzlin AS, Humes HD (2015) A multi-center, randomized, controlled, pivotal study to assess the safety and efficacy of a selective cytopheretic device in patients with acute kidney injury. PLoS One 10:e0132482PubMedPubMedCentralCrossRef
109.
Garbero E, Livigni S, Ferrari F, Finazzi S, Langer M, Malacarne P, Meca MCC, Mosca S, Olivieri C, Pozzato M, Rossi C, Tavola M, Terzitta M, Viaggi B, Bertolini G, GiViTi (2021) High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial. Intensive Care Med 47:1303–1311PubMedCrossRef
110.
Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC (2019) Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA 321:2003–2017PubMedPubMedCentralCrossRef
111.
Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M (2018) Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. Intensive Care Med 44:2205–2212PubMedPubMedCentralCrossRef
112.
Breilh D, Honore PM, De Bels D, Roberts JA, Gordien JB, Fleureau C, Dewitte A, Coquin J, Roze H, Perez P, Attou R, Redant S, Kugener L, Saux MC, Spapen HD, Ouattara A, Joannes-Boyau O, group Is (2019) Pharmacokinetics and pharmacodynamics of anti-infective agents during continuous veno-venous hemofiltration in critically ill patients: lessons learned from an ancillary study of the IVOIRE Trial. J Transl Int Med 7:155–169PubMedPubMedCentralCrossRef
113.
Monard C, Rimmele T, Ronco C (2019) Extracorporeal blood purification therapies for sepsis. Blood Purif 47(Suppl 3):1–14PubMed
114.
Ling RR, Ramanathan K, Poon WH, Tan CS, Brechot N, Brodie D, Combes A, MacLaren G (2021) Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis. Crit Care 25:246PubMedPubMedCentralCrossRef
Metadaten
Titel
Current practice and evolving concepts in septic shock resuscitation
verfasst von
Jan Bakker
Eduardo Kattan
Djillali Annane
Ricardo Castro
Maurizio Cecconi
Daniel De Backer
Arnaldo Dubin
Laura Evans
Michelle Ng Gong
Olfa Hamzaoui
Can Ince
Bruno Levy
Xavier Monnet
Gustavo A. Ospina Tascón
Marlies Ostermann
Michael R. Pinsky
James A. Russell
Bernd Saugel
Thomas W. L. Scheeren
Jean-Louis Teboul
Antoine Vieillard Baron
Jean-Louis Vincent
Fernando G. Zampieri
Glenn Hernandez
Publikationsdatum
15.12.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 2/2022
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-021-06595-9

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