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01.09.2014 | Musculoskeletal

Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

verfasst von: Jasper van Tiel, Gyula Kotek, Max Reijman, Pieter K. Bos, Esther E. Bron, Stefan Klein, Jan A. N. Verhaar, Gabriel P. Krestin, Harrie Weinans, Edwin H. G. Oei

Erschienen in: European Radiology | Ausgabe 9/2014

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Abstract

Objectives

To assess (1) whether normal and degenerated menisci exhibit different T1_GD on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1_GD in knee osteoarthritis (OA) patients.

Methods

In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1_GD was calculated. Meniscus pathology was evaluated on conventional MRI. T1_GD in normal and degenerated menisci were compared using a Student’s t-test. Reproducibility was assessed using ICCs. Pearson’s correlation was calculated between meniscus and cartilage T1_GD.

Results

A trend towards lower T1_GD in degenerated menisci (mean: 402 ms; 95 % CI: 359–444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423–473 ms) was observed (p = 0.05). Meniscus T1_GD ICCs were 0.85–0.90. The correlation between meniscus and cartilage T1_GD was moderate in the lateral (r = 0.52–0.75) and strong in the medial compartment (r = 0.78–0.94).

Conclusions

Our results show that degenerated menisci have a clear trend towards lower T1_GD compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1_GD suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific.

Key Points

• dGEMRIM T1 _GD can possibly be used to assess meniscal degeneration;

• dGEMRIM yields highly reproducible meniscal T1 _GD in early stage osteoarthritic patients;

• Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis;

• dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.

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Titel: Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC
verfasst von: Jasper van Tiel
Gyula Kotek
Max Reijman
Pieter K. Bos
Esther E. Bron
Stefan Klein
Jan A. N. Verhaar
Gabriel P. Krestin
Harrie Weinans
Edwin H. G. Oei
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3204-z

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Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC