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01.12.2014 | Original Article

Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry

verfasst von: Nicholas Chesnaye, Marjolein Bonthuis, Franz Schaefer, Jaap W. Groothoff, Enrico Verrina, James G. Heaf, Augustina Jankauskiene, Viktorija Lukosiene, Elena A. Molchanova, Conceicao Mota, Amira Peco-Antić, Ilse-Maria Ratsch, Anna Bjerre, Dimitar L. Roussinov, Alexander Sukalo, Rezan Topaloglu, Koen Van Hoeck, Ilona Zagozdzon, Kitty J. Jager, Karlijn J. Van Stralen, on behalf of theESPN/ERA–EDTA registry

Erschienen in: Pediatric Nephrology | Ausgabe 12/2014

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Abstract

Background

The ESPN/ERA–EDTA Registry collects data on European children with end-stage renal disease receiving renal replacement therapy (RRT) who are listed on national and regional renal registries in Europe. In this paper we report on the analysis of demographic data collected from 2009 to 2011.

Methods

Data on primary renal disease, incidence, prevalence, 4-year survival, transplantation rate and causes of death in paediatric patients receiving RRT were extracted from the ESPN/ERA–EDTA Registry for 37 European countries.

Results

The incidence of RRT in paediatric patients in Europe during the study period was 5.5 cases per million age-related population (pmarp) in patients aged 0–14 years and varied markedly between countries (interquartile range 3.4–7.0 years). The prevalence of RRT was 27.9 pmarp and increased with age, with 67 % of prevalent patients living with a functioning graft. The probability of receiving a transplant within 4 years was 76.9 % and was lowest in patients aged 0–4 years (68.9 %). Mortality in paediatric patients treated with RRT was 55-fold higher than that of the general EU paediatric population. Overall survival at 4 years was 93.7 %, with the poorest survival in patients aged 0–4 years and in patients starting on dialysis. Infections (19.9 %) were the primary cause of death in European paediatric RRT patients.

Conclusion

Considerable variation exists in the current demographics of children treated with RRT across Europe.

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Titel: Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry
verfasst von: Nicholas Chesnaye
Marjolein Bonthuis
Franz Schaefer
Jaap W. Groothoff
Enrico Verrina
James G. Heaf
Augustina Jankauskiene
Viktorija Lukosiene
Elena A. Molchanova
Conceicao Mota
Amira Peco-Antić
Ilse-Maria Ratsch
Anna Bjerre
Dimitar L. Roussinov
Alexander Sukalo
Rezan Topaloglu
Koen Van Hoeck
Ilona Zagozdzon
Kitty J. Jager
Karlijn J. Van Stralen
on behalf of theESPN/ERA–EDTA registry
Publikationsdatum: 01.12.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 12/2014
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2884-6

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Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry