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European Radiology

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01.10.2012 | Head and Neck

Detection of neck recurrence in patients with differentiated thyroid cancer: comparison of ultrasound, contrast-enhanced CT and ¹⁸F-FDG PET/CT using surgical pathology as a reference standard: (ultrasound vs. CT vs. ¹⁸F-FDG PET/CT in recurrent thyroid cancer)

verfasst von: Young Lan Seo, Dae Young Yoon, Sora Baek, You Jin Ku, Young-Soo Rho, Eun-Jae Chung, Sung Hye Koh

Erschienen in: European Radiology | Ausgabe 10/2012

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Abstract

Objectives

To compare the diagnostic performance of ultrasound, contrast-enhanced computed tomography (CT) and ¹⁸F-FDG positron emission tomography (PET)/CT for detecting recurrent differentiated thyroid cancer in the neck.

Methods

Twenty patients who had undergone previous surgery for differentiated thyroid cancer (19 papillary carcinomas; 1 medullary carcinoma) and presented with pathologically proven recurrence in the neck were included. All patients had undergone ultrasound, CT and PET/CT in the 2 months before further surgery. In each patient, ultrasound, CT and PET/CT images were retrospectively reviewed to determine the presence of loco-regional recurrence by level-by-level analysis. Imaging results were correlated with the histological evaluation of the neck dissection as a standard of reference.

Results

Recurrences were found at 52 out of 110 cervical nodal levels surgically explored. The sensitivity, specificity and accuracy were 69.2 %, 89.7 % and 80.0 % for ultrasound; 63.5 %, 94.8 % and 80.0 % for CT; and 53.8 %, 79.3 % and 67.3 % for PET/CT, respectively. ROC analysis revealed higher diagnostic performance with ultrasound than with PET/CT for detecting recurrent tumour.

Conclusions

Although no significant difference was found among the three techniques, the sensitivity and specificity of ultrasound and CT were higher than those of PET/CT for the evaluation of cervical recurrence in patients with differentiated thyroid cancer.

Key Points

• Ultrasound, CT and ¹⁸ F-FDG PET/CT can all detect recurrent thyroid cancer.

• Ultrasound and CT have higher sensitivity and specificity.

• Ultrasound, CT and ¹⁸ F-FDG PET/CT frequently demonstrated discordant findings

Johnson NA, Tublin ME (2008) Postoperative surveillance of differentiated thyroid carcinoma: rationale, techniques, and controversies. Radiology 249:429–444PubMedCrossRef

Aygun N (2008) Imaging of recurrent thyroid cancer. Otolaryngol Clin North Am 41:1095–1106PubMedCrossRef

Mazzaferri EL, Jhiang SM (1994) Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97:418–428PubMedCrossRef

Lee JH, Lee HK, Lee DH et al (2007) Ultrasonographic findings of a newly detected nodule on the thyroid bed in postoperative patients for thyroid carcinoma: correlation with the results of ultrasonography-guided fine-needle aspiration biopsy. Clin Imaging 31:109–113PubMedCrossRef

Vassallo P, Wernecke K, Roos N, Peters PE (1992) Differentiation of benign from malignant superficial lymphadenopathy: the role of high-resolution US. Radiology 183:215–220PubMed

Rosário PW, de Faria S, Bicalho L et al (2005) Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma. J Ultrasound Med 24:1385–1389PubMed

Sakai O, Curtin HD, Romo LV, Som PM (2000) Lymph node pathology: benign proliferative, lymphoma, and metastatic disease. Radiol Clin North Am 38:979–998PubMedCrossRef

Som PM, Brandwein M, Lidov M, Lawson W, Biller HF (1994) The varied presentations of papillary thyroid carcinoma cervical nodal disease: CT and MR findings. Am J Neuroradiol 15:1123–1128PubMed

van den Brekel MW, Stel HV, Castelijns JA et al (1990) Cervical lymph node metastasis: assessment of radiological criteria. Radiology 177:379–384PubMed

10.

Nygaard B, Nygaard T, Jensen LI et al (1998) Iohexol: effects on uptake of radioactive iodine in the thyroid and on thyroid function. Acad Radiol 5:409–414PubMedCrossRef

11.

Dietlein M, Scheidhauer K, Voth E, Theissen P, Schicha H (1997) Fluorine-18 fluorodeoxyglucose positron emission tomography and iodine-131 whole-body scintigraphy in the follow-up of differentiated thyroid cancer. Eur J Nucl Med 24:1342–1348PubMedCrossRef

12.

Jeong HS, Baek CH, Son YI et al (2006) Integrated ¹⁸F-FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast-enhanced CT. Clin Endocrinol (Oxf) 65:402–407CrossRef

13.

Haerle SK, Strobel K, Ahmad N, Soltermann A, Schmid DT, Stoeckli SJ (2011) Contrast-enhanced ¹⁸F-FDG-PET/CT for the assessment of necrotic lymph node metastases. Head Neck 33:324–329PubMed

14.

Nakagawa T, Yamada M, Suzuki Y (2008) ¹⁸F-FDG uptake in reactive neck lymph nodes of oral cancer: relationship to lymphoid follicles. J Nucl Med 49:1053–1059PubMedCrossRef

15.

Altenvoerde G, Lerch H, Kuwert T, Matheja P, Schäfers M, Schober O (1998) Positron emission tomography with F-18-deoxyglucose in patients with differentiated thyroid carcinoma, elevated thyroglobulin levels, and negative iodine scans. Langenbecks Arch Surg 383:160–163PubMed

16.

Grünwald F, Schomburg A, Bender H et al (1996) Fluorine-18 fluorodeoxyglucose positron emission tomography in the follow-up of differentiated thyroid cancer. Eur J Nucl Med 23:312–319PubMedCrossRef

17.

Mazzaferri EL, Robbins RJ, Spencer CA et al (2003) A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:1433–1441PubMedCrossRef

18.

Cooper DS, Doherty GM, Haugen BR et al (2006) Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16:109–142PubMedCrossRef

19.

Sherman SI, Tielens ET, Sostre S, Wharam MD Jr, Ladenson PW (1994) Clinical utility of post treatment radioiodine scans in the management of patients with thyroid carcinoma. J Clin Endocrinol Metab 78:629–634PubMedCrossRef

20.

Lee DH, Kang WJ, Seo HS et al (2009) Detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma: computed tomography versus positron emission tomography-computed tomography. J Comput Assist Tomogr 33:805–810PubMedCrossRef

21.

Choi JW, Lee JH, Baek JH et al (2010) Diagnostic accuracy of ultrasound and 18-F-FDG PET or PET/CT for patients with suspected recurrent papillary thyroid carcinoma. Ultrasound Med Biol 36:1608–1615PubMedCrossRef

22.

Som PM, Curtin HD, Mancuso AA (2000) Imaging-based nodal classification for evaluation of neck metastatic adenopathy. Am J Roentgenol 174:837–844

23.

Kuna SK, Bracic I, Tesic V, Kuna K, Herceg GH, Dodig D (2006) Ultrasonographic differentiation of benign from malignant neck lymphadenopathy in thyroid cancer. J Ultrasound Med 25:1531–1537PubMed

24.

Kim E, Park JS, Son KR, Kim JH, Jeon SJ, Na DG (2008) Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma: comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography. Thyroid 18:411–418PubMedCrossRef

25.

Feine U, Lietzenmayer R, Hanke JP, Held J, Wöhrle H, Müller-Schauenburg W (1996) Fluorine-18-FDG and iodine-131-iodide uptake in thyroid cancer. J Nucl Med 37:1468–1472PubMed

26.

Ferris RL, Branstetter BF, Nayak JV (2005) Diagnostic utility of positron emission tomography-computed tomography for predicting malignancy in cystic neck masses in adults. Laryngoscope 115:1979–1982PubMedCrossRef

27.

Crippa F, Leutner M, Belli F et al (2000) Which kinds of lymph node metastases can FDG PET detect? a clinical study in melanoma. J Nucl Med 41:1491–1494PubMed

28.

Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T (1992) Intratumoral distribution of fluorine-18 fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 33:1972–1980PubMed

Titel: Detection of neck recurrence in patients with differentiated thyroid cancer: comparison of ultrasound, contrast-enhanced CT and 18F-FDG PET/CT using surgical pathology as a reference standard: (ultrasound vs. CT vs. 18F-FDG PET/CT in recurrent thyroid cancer)
verfasst von: Young Lan Seo
Dae Young Yoon
Sora Baek
You Jin Ku
Young-Soo Rho
Eun-Jae Chung
Sung Hye Koh
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 10/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2470-x

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Detection of neck recurrence in patients with differentiated thyroid cancer: comparison of ultrasound, contrast-enhanced CT and ¹⁸F-FDG PET/CT using surgical pathology as a reference standard: (ultrasound vs. CT vs. ¹⁸F-FDG PET/CT in recurrent thyroid cancer)

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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