Skip to main content
Erschienen in: Intensive Care Medicine 4/2012

01.04.2012 | Original

Development of demographics and outcome of very old critically ill patients admitted to intensive care units

verfasst von: Gerald C. Ihra, Judith Lehberger, Helene Hochrieser, Peter Bauer, Rene Schmutz, Barbara Metnitz, Philipp G. H. Metnitz

Erschienen in: Intensive Care Medicine | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To evaluate the development of demographics and outcome of very old (>80 years) critically ill patients admitted to intensive care units.

Setting

All consecutive patients admitted to 41 Austrian intensive care units (ICUs) over an 11-year period.

Methods

We performed a retrospective cohort study of prospectively collected data. To compare parameters over time, patients were divided into three groups (group I from 1998 until 2001, group II from 2002 to 2004, and group III from 2005 to 2008).

Results

A total of 17,126 patients older than 80 years of age were admitted over the study period. The proportion of very old patients increased from 11.5% (I) to 15.3% (III) with a significant higher prevalence of females in all groups (on average 63.2%). Severity of illness also increased over time, even when corrected for age. Use of noninvasive mechanical ventilation increased over the years. However, risk-adjusted mortality rates [observed-to-expected (O/E) ratios] decreased from 1.14 [confidence interval (CI) 1.11–1.18] to 1.02 (CI 0.99–1.05). This improvement in outcome was confirmed on multivariate analysis: for every year delay in ICU admission, the odds to die decreased by 3%. Moreover, females exhibited a better outcome compared with males.

Conclusions

The relative and absolute numbers of very old patients increased over the study period, as did the severity of illness. Despite this, risk-adjusted hospital mortality improved over the study period. Females dominated in the very old patients and exhibited moreover a better outcome compared with males.
Literatur
2.
Zurück zum Zitat Bongaarts J (2009) Human population growth and the demographic transition. Phil Trans R Soc B 364:2985–2990PubMedCrossRef Bongaarts J (2009) Human population growth and the demographic transition. Phil Trans R Soc B 364:2985–2990PubMedCrossRef
3.
Zurück zum Zitat Lutz W, Sanderson W, Scherbov S (2008) The coming acceleration of global population ageing. Nature 451:716–719PubMedCrossRef Lutz W, Sanderson W, Scherbov S (2008) The coming acceleration of global population ageing. Nature 451:716–719PubMedCrossRef
4.
Zurück zum Zitat Rosenthal GE, Kaboli PJ, Barnett MJ, Sirio CA (2002) Age and the risk of in-hospital death: insights from a multihospital study of intensive care patients. J Am Geriatr Soc 50:1205–1212PubMedCrossRef Rosenthal GE, Kaboli PJ, Barnett MJ, Sirio CA (2002) Age and the risk of in-hospital death: insights from a multihospital study of intensive care patients. J Am Geriatr Soc 50:1205–1212PubMedCrossRef
5.
Zurück zum Zitat Creditor MC (1993) Hazards of hospitalization of the elderly. Ann Intern Med 118:219–222PubMed Creditor MC (1993) Hazards of hospitalization of the elderly. Ann Intern Med 118:219–222PubMed
6.
Zurück zum Zitat Bagshaw SM, Webb SAR, Delaney A, George C, Pilcher D, Hart GK, Bellomo R (2009) Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care 13:R45PubMedCrossRef Bagshaw SM, Webb SAR, Delaney A, George C, Pilcher D, Hart GK, Bellomo R (2009) Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care 13:R45PubMedCrossRef
7.
Zurück zum Zitat Somme D, Maillet JM, Gisselbrecht M, Novara A, Ract C, Fagon JY (2003) Critically ill old and the oldest-old patients in intensive care: short- and long-term outcomes. Intensive Care Med 29:2137–2143PubMedCrossRef Somme D, Maillet JM, Gisselbrecht M, Novara A, Ract C, Fagon JY (2003) Critically ill old and the oldest-old patients in intensive care: short- and long-term outcomes. Intensive Care Med 29:2137–2143PubMedCrossRef
8.
Zurück zum Zitat Boumendil A, Somme D, Garrouste-Orgeas M, Guidet B (2007) Should elderly patients be admitted to the intensive care unit? Intensive Care Med 33:1252–1262PubMedCrossRef Boumendil A, Somme D, Garrouste-Orgeas M, Guidet B (2007) Should elderly patients be admitted to the intensive care unit? Intensive Care Med 33:1252–1262PubMedCrossRef
9.
Zurück zum Zitat Nguyen YL, Angus DC, Boumendil A, Guidet B (2011) The challenge of admitting the very elderly to intensive care. Ann Intensive Care 1:29PubMedCrossRef Nguyen YL, Angus DC, Boumendil A, Guidet B (2011) The challenge of admitting the very elderly to intensive care. Ann Intensive Care 1:29PubMedCrossRef
10.
Zurück zum Zitat Metnitz PhGH, Vesely H, Valentin A, Popow C, Hiesmayr M, Lenz K, Krenn CG, Steltzer H (1999) Evaluation of an interdisciplinary data set for national ICU assessment. Crit Care Med 27:1486–1491PubMedCrossRef Metnitz PhGH, Vesely H, Valentin A, Popow C, Hiesmayr M, Lenz K, Krenn CG, Steltzer H (1999) Evaluation of an interdisciplinary data set for national ICU assessment. Crit Care Med 27:1486–1491PubMedCrossRef
11.
Zurück zum Zitat Metnitz PhGH, Steltzer H, Popow C, Valentin A, Lenz K, Neumark J, Sagmüller G, Schwameis F, Urschitz M, Hiesmayr M (1997) Definition and evaluation of a documentation standard for intensive care medicine: the ASDI pilot project. Wien Klin Wochenschr 109:132–138PubMed Metnitz PhGH, Steltzer H, Popow C, Valentin A, Lenz K, Neumark J, Sagmüller G, Schwameis F, Urschitz M, Hiesmayr M (1997) Definition and evaluation of a documentation standard for intensive care medicine: the ASDI pilot project. Wien Klin Wochenschr 109:132–138PubMed
12.
Zurück zum Zitat Le Gall JR, Lemeshow St, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2963PubMedCrossRef Le Gall JR, Lemeshow St, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957–2963PubMedCrossRef
13.
Zurück zum Zitat Miranda DR, De Rijk A, Schaufeli W (1996) Simplified therapeutic interventions scoring system: the TISS-28 items—results from a multicenter study. Crit Care Med 4:64–73CrossRef Miranda DR, De Rijk A, Schaufeli W (1996) Simplified therapeutic interventions scoring system: the TISS-28 items—results from a multicenter study. Crit Care Med 4:64–73CrossRef
14.
Zurück zum Zitat Metnitz PhGH, Krenn CG, Steltzer H, Lang Th, Ploder J, Lenz K, Le Gall JR, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058PubMedCrossRef Metnitz PhGH, Krenn CG, Steltzer H, Lang Th, Ploder J, Lenz K, Le Gall JR, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058PubMedCrossRef
15.
Zurück zum Zitat Hosmer DW, Lemeshow S (1995) Confidence interval estimates of an index of quality performance based on logistic regression models. Stat Med 14:2161–2172PubMedCrossRef Hosmer DW, Lemeshow S (1995) Confidence interval estimates of an index of quality performance based on logistic regression models. Stat Med 14:2161–2172PubMedCrossRef
16.
Zurück zum Zitat Bauer P, Poetscher BM, Hackl P (1988) Model selection by multiple test procedures. Statistics 19:39–44CrossRef Bauer P, Poetscher BM, Hackl P (1988) Model selection by multiple test procedures. Statistics 19:39–44CrossRef
17.
Zurück zum Zitat Angus DC, Kelley MA, Schmitz RJ, White A, Popovich J (2000) Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease. JAMA 284:2762–2770PubMedCrossRef Angus DC, Kelley MA, Schmitz RJ, White A, Popovich J (2000) Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease. JAMA 284:2762–2770PubMedCrossRef
19.
Zurück zum Zitat Garrouste-Orgeas M, Timsit JF, Montuclard L, Colvez A, Gattoliat O, Philippart F, Rigal G, Misset B, Carlet J (2006) Decision-making progress, outcome, and 1-year quality of life of octogenarians referred for intensive care unit admission. Intensive Care Med 32:1045–1051PubMedCrossRef Garrouste-Orgeas M, Timsit JF, Montuclard L, Colvez A, Gattoliat O, Philippart F, Rigal G, Misset B, Carlet J (2006) Decision-making progress, outcome, and 1-year quality of life of octogenarians referred for intensive care unit admission. Intensive Care Med 32:1045–1051PubMedCrossRef
20.
Zurück zum Zitat Hamel MB, Teno JM, Goldmann L, Lynn J, Davis RB, Galanos AN, Desbiens N, Connors AF, Wenger N, Phillips RS (1999) Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. Ann Intern Med 130:116–125PubMed Hamel MB, Teno JM, Goldmann L, Lynn J, Davis RB, Galanos AN, Desbiens N, Connors AF, Wenger N, Phillips RS (1999) Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. Ann Intern Med 130:116–125PubMed
21.
Zurück zum Zitat Garrouste-Orgeas M, Boumendil A, Pateron D, Aergerter P, Somme D, Simon T, Guidet B, ICE-CUB Group (2009) Selection of intensive care unit admission criteria for patients aged 80 years and over and compliance of emergency and intensive care unit physicians with the selected criteria: An observational, multicenter, prospective study. Crit Care Med 37:2919–2928PubMedCrossRef Garrouste-Orgeas M, Boumendil A, Pateron D, Aergerter P, Somme D, Simon T, Guidet B, ICE-CUB Group (2009) Selection of intensive care unit admission criteria for patients aged 80 years and over and compliance of emergency and intensive care unit physicians with the selected criteria: An observational, multicenter, prospective study. Crit Care Med 37:2919–2928PubMedCrossRef
22.
Zurück zum Zitat Boumendil A, Aegerter P, Guidet B, the CUB-Rea Network (2005) Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study. J Am Geriatr Soc 53:88–93PubMedCrossRef Boumendil A, Aegerter P, Guidet B, the CUB-Rea Network (2005) Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study. J Am Geriatr Soc 53:88–93PubMedCrossRef
23.
Zurück zum Zitat Lerolle N, Trinquart L, Bornstain C, Tadié JM, Imbert A, Diehl JL, Fagon JY, Guérot E (2010) Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Crit Care Med 38:59–64PubMedCrossRef Lerolle N, Trinquart L, Bornstain C, Tadié JM, Imbert A, Diehl JL, Fagon JY, Guérot E (2010) Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Crit Care Med 38:59–64PubMedCrossRef
24.
Zurück zum Zitat Needham DM, Bronskill SE, Calinawan JR, Sibbald WJ, Pronovost PJ, Laupacis A (2005) Projected incidence of mechanical ventilation in Ontario to 2026: preparing for the aging baby boomers. Crit Care Med 33:574–579PubMedCrossRef Needham DM, Bronskill SE, Calinawan JR, Sibbald WJ, Pronovost PJ, Laupacis A (2005) Projected incidence of mechanical ventilation in Ontario to 2026: preparing for the aging baby boomers. Crit Care Med 33:574–579PubMedCrossRef
25.
Zurück zum Zitat Van Den Noorgate N, Vogelaers D, Afschrift M, Colardyn F (1999) Intensive care for elderly patients: outcome and risk factors for in-hospital mortality. Age Ageing 28:253–256CrossRef Van Den Noorgate N, Vogelaers D, Afschrift M, Colardyn F (1999) Intensive care for elderly patients: outcome and risk factors for in-hospital mortality. Age Ageing 28:253–256CrossRef
26.
Zurück zum Zitat Nin N, Lorente JA, Paula M, Fernandez Segoviano P, Penuelas O, Sanchez Ferrer A, Martinez Caro L, Esteban A (2008) Ageing increases the susceptibility to injurious mechanical ventilation. Intensive Care Med 34:923–931PubMedCrossRef Nin N, Lorente JA, Paula M, Fernandez Segoviano P, Penuelas O, Sanchez Ferrer A, Martinez Caro L, Esteban A (2008) Ageing increases the susceptibility to injurious mechanical ventilation. Intensive Care Med 34:923–931PubMedCrossRef
27.
Zurück zum Zitat Behrendt CE (2000) Acute respiratory failure in the United States: Incidence and 31-day survival. Chest 118:1100–1105PubMedCrossRef Behrendt CE (2000) Acute respiratory failure in the United States: Incidence and 31-day survival. Chest 118:1100–1105PubMedCrossRef
28.
Zurück zum Zitat Ely EW, Wheeler AP, Thompson BT, Ancukiewicz M, Steinberg KP, Bernard GR (2002) Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med 136:25–36PubMed Ely EW, Wheeler AP, Thompson BT, Ancukiewicz M, Steinberg KP, Bernard GR (2002) Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med 136:25–36PubMed
29.
Zurück zum Zitat Evans TW (2001) International consensus conferences in intensive care medicine: non-invasive positive pressure ventilation in acute respiratory failure. Intensive Care Med 27:166–178PubMedCrossRef Evans TW (2001) International consensus conferences in intensive care medicine: non-invasive positive pressure ventilation in acute respiratory failure. Intensive Care Med 27:166–178PubMedCrossRef
30.
Zurück zum Zitat Demoule A, Girou E, Richard JC, Taillé S, Brochard L (2006) Increased use of noninvasive ventilation in French intensive care units. Intensive Care Med 32:1747–1755PubMedCrossRef Demoule A, Girou E, Richard JC, Taillé S, Brochard L (2006) Increased use of noninvasive ventilation in French intensive care units. Intensive Care Med 32:1747–1755PubMedCrossRef
31.
Zurück zum Zitat Nava S, Grassi M, Fanfulla F, Domenighetti G, Carlucci A, Perren A, Dell’orso D, Vitacca M, Ceriana P, Karakurt Z, Clini E (2011) Non-invasive ventilation in elderly patients with acute hypercapnic respiratory failure: a randomized controlled trial. Age Ageing 40:444–450PubMedCrossRef Nava S, Grassi M, Fanfulla F, Domenighetti G, Carlucci A, Perren A, Dell’orso D, Vitacca M, Ceriana P, Karakurt Z, Clini E (2011) Non-invasive ventilation in elderly patients with acute hypercapnic respiratory failure: a randomized controlled trial. Age Ageing 40:444–450PubMedCrossRef
32.
Zurück zum Zitat Nicolas F, Le Gall JR, Alperovitch A, Loirat P, Villers D (1987) Influence of patients’ age on survival, level of therapy and length of stay in intensive care units. Intensive Care Med 13:9–13PubMedCrossRef Nicolas F, Le Gall JR, Alperovitch A, Loirat P, Villers D (1987) Influence of patients’ age on survival, level of therapy and length of stay in intensive care units. Intensive Care Med 13:9–13PubMedCrossRef
33.
Zurück zum Zitat Goldhill DR, Sumner A (1998) Outcome of intensive care patients in a group of British intensive care units. Crit Care Med 26:1337–1345PubMedCrossRef Goldhill DR, Sumner A (1998) Outcome of intensive care patients in a group of British intensive care units. Crit Care Med 26:1337–1345PubMedCrossRef
34.
35.
Zurück zum Zitat Pietropaoli AP, Glance LG, Oakes D, Fisher SG (2010) Gender differences in mortality in patients with sever sepsis or septic shock. Gend Med 7:422–437PubMedCrossRef Pietropaoli AP, Glance LG, Oakes D, Fisher SG (2010) Gender differences in mortality in patients with sever sepsis or septic shock. Gend Med 7:422–437PubMedCrossRef
36.
Zurück zum Zitat Fowler RA, Sabur N, Li P, Juurlink DN, Pinto R, Hladunewich MA, Adhikari NKJ, Sibbald WJ, Martin CM (2007) Sex- and age-based differences in the delivery and outcomes of critical care. CMAJ 177:1513–1519PubMedCrossRef Fowler RA, Sabur N, Li P, Juurlink DN, Pinto R, Hladunewich MA, Adhikari NKJ, Sibbald WJ, Martin CM (2007) Sex- and age-based differences in the delivery and outcomes of critical care. CMAJ 177:1513–1519PubMedCrossRef
37.
Zurück zum Zitat Reinikainen M, Niskanen M, Uusaro A, Ruokonen E (2005) Impact of gender on treatment and outcome of ICU patients. Acta Anaesthesiol Scand 49:984–990PubMedCrossRef Reinikainen M, Niskanen M, Uusaro A, Ruokonen E (2005) Impact of gender on treatment and outcome of ICU patients. Acta Anaesthesiol Scand 49:984–990PubMedCrossRef
38.
Zurück zum Zitat Valentin A, Jordan B, Lang T, Hiesmayr M, Metnitz PGH (2003) Gender-related differences in intensive care: a multiple center cohort study of therapeutic interventions and outcome in critically ill patients. Crit Care Med 31:1901–1907PubMedCrossRef Valentin A, Jordan B, Lang T, Hiesmayr M, Metnitz PGH (2003) Gender-related differences in intensive care: a multiple center cohort study of therapeutic interventions and outcome in critically ill patients. Crit Care Med 31:1901–1907PubMedCrossRef
Metadaten
Titel
Development of demographics and outcome of very old critically ill patients admitted to intensive care units
verfasst von
Gerald C. Ihra
Judith Lehberger
Helene Hochrieser
Peter Bauer
Rene Schmutz
Barbara Metnitz
Philipp G. H. Metnitz
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 4/2012
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2474-7

Weitere Artikel der Ausgabe 4/2012

Intensive Care Medicine 4/2012 Zur Ausgabe

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.