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European Archives of Oto-Rhino-Laryngology

Erschienen in:

07.04.2024 | Laryngology

Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study

verfasst von: Wanxi Qu, Zhaohui Qin, Li Cui, Shiwang Yuan, Nan Yao, Ji Ma, Jiaying Lu, Jiang Wang, Minhan Wang, Yuanhu Yao

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 6/2024

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Abstract

Purpose

To establish two nomograms to quantify the risk of lung metastasis (LM) in laryngeal carcinoma (LC) and predict the overall survival of LC patients with LM.

Methods

Totally 9515 LC patients diagnosed histologically from 2000 to 2019 were collected from the Surveillance, Epidemiology, and End Results database. The independent diagnostic factors for LM in LC patients and prognostic factors for LC patients with LM were identified by logistic and Cox regression analysis, respectively. Nomograms were established based on regression coefficients and evaluated by receiver operating characteristic curve, calibration curves, and decision curve analysis.

Results

Patients with supraglottis, higher pathological grade, higher N stage, and distant metastasis (bone, brain, or liver) were more likely to have LM (P < 0.05). Chemotherapy, surgery and radiotherapy were independent factors of the overall survival of LC patients with LM (P < 0.05). The area under curve of diagnostic nomogram were 0.834 and 0.816 in the training and validation cohort respectively. For the prognostic nomogram, the area under curves of 1-, 2-, and 3-years were 0.735, 0.734, and 0.709 in the training cohort and 0.705, 0.803, and 0.809 in the validation cohort. The calibration curves and decision curve analysis indicated good performance of the nomograms.

Conclusion

Distant metastasis (bone, brain, or liver) and N stage should be considered for prediction of LM in LC patients. Chemotherapy is the most significant influencing prognostic factor improving the survival of LC patients with LM. Two nomograms may benefit for providing better precautionary measures and treatment decision.

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Titel: Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study
verfasst von: Wanxi Qu
Zhaohui Qin
Li Cui
Shiwang Yuan
Nan Yao
Ji Ma
Jiaying Lu
Jiang Wang
Minhan Wang
Yuanhu Yao
Publikationsdatum: 07.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 6/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08608-x

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Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study