nach oben

European Journal of Nutrition

Erschienen in:

11.02.2019 | Review

Dietary total antioxidant capacity and mortality from all causes, cardiovascular disease and cancer: a systematic review and dose–response meta-analysis of prospective cohort studies

verfasst von: Mohammad Parohan, Javad Anjom-Shoae, Morteza Nasiri, Mahmoud Khodadost, Seyed Reza Khatibi, Omid Sadeghi

Erschienen in: European Journal of Nutrition | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

No conclusive information is available about the association between dietary total antioxidant capacity (DTAC) and risk of mortality. Current meta-analysis of prospective cohort studies was done to summarize available findings on the association between DTAC and risk of death from all-cause, cancer and cardiovascular diseases (CVDs).

Methods

Online databases were searched to detect relevant publications up to January 2018, using relevant keywords. To pool data, either fixed-effects or random-effects model was used. Furthermore, linear and non-linear dose–response analyses were also done.

Results

In total, five prospective studies were included in the current systematic review and meta-analysis. In a follow-up period of 4.3–16.5 years, there were 38,449 deaths from all-cause, 4470 from cancer and 2841 from CVDs among 226,297 individuals. A significant inverse association was found between DTAC and all-cause mortality (combined effect size: 0.62, 95% CI 0.60–0.64). Such finding was also seen for cancer (combined effect size: 0.81, 95% CI 0.75–0.88) and CVD (combined effect size: 0.71, 95% CI 0.63–0.82) mortality. Findings from linear dose–response meta-analysis revealed that a 5 mmol/day increment in DTAC based on ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) was associated with 7% and 15% lower risk of all-cause mortality, respectively. Based on findings from non-linear dose–response meta-analysis, a significant reduction in risk of all-cause mortality was seen when increasing FRAP from 2 to 12 mmol/day (P-nonlinearity = 0.002) and ORAC from 5 to 11 mmol/day (P-nonlinearity < 0.001).

Conclusions

Adherence to diet with high total antioxidant capacity was associated with decreased risk of death from all-cause, cancer and CVDs.

Nur mit Berechtigung zugänglich

Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49:1603–1616. https://doi.org/10.1016/j.freeradbiomed.2010.09.006 CrossRefPubMedPubMedCentral

Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC (2017) Oxidative stress and cardiovascular risk: obesity, diabetes, smoking, and pollution: part 3 of a 3-part series. J Am Coll Cardiol 70:230–251. https://doi.org/10.1016/j.jacc.2017.05.043 CrossRefPubMedPubMedCentral

Robson R, Kundur AR, Singh I (2017) Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk. Diabetes Metab Syndr. https://doi.org/10.1016/j.dsx.2017.12.029 CrossRefPubMed

Xie Z, Lin H, Fang R, Shen W, Li S, Chen B (2015) Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study. Environ Health 14:40. https://doi.org/10.1186/s12940-015-0028-5 CrossRefPubMedPubMedCentral

de la Iglesia R, Lopez-Legarrea P, Celada P, Sanchez-Muniz FJ, Martinez JA, Zulet MA (2013) Beneficial effects of the RESMENA dietary pattern on oxidative stress in patients suffering from metabolic syndrome with hyperglycemia are associated to dietary TAC and fruit consumption. Int J Mol Sci 14:6903–6919. https://doi.org/10.3390/ijms14046903 CrossRefPubMedPubMedCentral

Kim K, Vance TM, Chen M-H, Chun OK (2017) Dietary total antioxidant capacity is inversely associated with all-cause and cardiovascular disease death of US adults. Eur J Nutr 57:2469–2476. https://doi.org/10.1007/s00394-017-1519-7 CrossRefPubMed

Bastide N, Dartois L, Dyevre V, Dossus L, Fagherazzi G, Serafini M et al (2017) Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study. Eur J Nutr 56:1233–1243CrossRefPubMed

Michaëlsson K, Wolk A, Melhus H, Byberg L (2017) Milk, fruit and vegetable, and total antioxidant intakes in relation to mortality rates: cohort studies in women and men. Am J Epidemiol 185:345–361CrossRefPubMedPubMedCentral

Henriquez-Sanchez P, Sánchez-Villegas A, Ruano-Rodríguez C, Gea A, Lamuela-Raventós RM, Estruch R et al (2016) Dietary total antioxidant capacity and mortality in the PREDIMED study. Eur J Nutr 55:227–236CrossRefPubMed

10.

Agudo A, Cabrera L, Amiano P, Ardanaz E, Barricarte A, Berenguer T et al (2007) Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). Am J Clin Nutr 85:1634–1642CrossRefPubMed

11.

Peng C, Luo WP, Zhang CX (2017) Fruit and vegetable intake and breast cancer prognosis: a meta-analysis of prospective cohort studies. Br J Nutr 117:737–749. https://doi.org/10.1017/s0007114517000423 CrossRefPubMed

12.

Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W et al (2014) Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. Bmj 349:g4490. https://doi.org/10.1136/bmj.g4490 CrossRefPubMedPubMedCentral

13.

Wang Q, Chen Y, Wang X, Gong G, Li G, Li C (2014) Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: results from a meta-analysis of cohort studies. Eur J Cancer 50:1498–1509. https://doi.org/10.1016/j.ejca.2014.02.009 CrossRefPubMed

14.

Tabernero M, Serrano J, Saura-Calixto F (2006) The antioxidant capacity of cocoa products: contribution to the Spanish diet. Int J Food Sci Technol 41:28–32CrossRef

15.

Pellegrini N, Serafini M, Colombi B, Del Rio D, Salvatore S, Bianchi M et al (2003) Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr 133:2812–2819CrossRefPubMed

16.

Dietrich M, Jacques P, Pencina M, Lanier K, Keyes M, Kaur G et al (2009) Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? Atherosclerosis 205:549–553CrossRefPubMed

17.

Zhao LG, Shu XO, Li HL, Zhang W, Gao J, Sun JW et al (2017) Dietary antioxidant vitamins intake and mortality: A report from two cohort studies of Chinese adults in Shanghai. J Epidemiol 27:89–97. https://doi.org/10.1016/j.je.2016.10.002 CrossRefPubMed

18.

Buijsse B, Feskens EJ, Kwape L, Kok FJ, Kromhout D (2008) Both alpha- and beta-carotene, but not tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in Dutch elderly men. J Nutr 138:344–350CrossRefPubMed

19.

Pellegrini N, Vitaglione P, Granato D, Fogliano V (2018) Twenty-five years of total antioxidant capacity measurement of foods and biological fluids: merits and limitations. J Sci Food Agric. https://doi.org/10.1002/jsfa.9550 CrossRefPubMed

20.

Fraga CG, Oteiza PI, Galleano M (2014) In vitro measurements and interpretation of total antioxidant capacity. Biochim Biophys Acta 1840:931–934. https://doi.org/10.1016/j.bbagen.2013.06.030 CrossRefPubMed

21.

Pompella A, Sies H, Wacker R, Brouns F, Grune T, Biesalski HK et al (2014) The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged. Nutrition 30:791–793. https://doi.org/10.1016/j.nut.2013.12.002 CrossRefPubMed

22.

Manach C, Williamson G, Morand C, Scalbert A, Remesy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230s–242s. https://doi.org/10.1093/ajcn/81.1.230S CrossRefPubMed

23.

Basu A, Morris S, Nguyen A, Betts NM, Fu D, Lyons TJ (2016) Effects of dietary strawberry supplementation on antioxidant biomarkers in obese adults with above optimal serum lipids. J Nutr Metab 2016:3910630. https://doi.org/10.1155/2016/3910630.CrossRefPubMedPubMedCentral

24.

Pinzani P, Petruzzi E, Magnolfi SU, Malentacchi F, De Siena G, Petruzzi I et al (2010) Red or white wine assumption and serum antioxidant capacity. Arch Gerontol Geriatr 51:e72–e74. https://doi.org/10.1016/j.archger.2009.12.007 CrossRefPubMed

25.

Koutelidakis AE, Rallidis L, Koniari K, Panagiotakos D, Komaitis M, Zampelas A (2014) Anastasiou-Nana M, Kapsokefalou M. Effect of green tea on postprandial antioxidant capacity, serum lipids, C-reactive protein and glucose levels in patients with coronary artery disease. Eur J Nutr 53:479–486. https://doi.org/10.1007/s00394-013-0548-0 CrossRefPubMed

26.

Lettieri-Barbato D, Villaño D, Beheydt B, Guadagni F, Trogh I, Serafini M (2012) Effect of ingestion of dark chocolates with similar lipid composition and different cocoa content on antioxidant and lipid status in healthy humans. Food Chem 132:1305–1310. https://doi.org/10.1016/j.foodchem.2011.11.109 CrossRefPubMed

27.

Yang M, Chung SJ, Floegel A, Song WO, Koo SI, Chun OK (2013) Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations. Eur J Nutr 52:1901–1911. https://doi.org/10.1007/s00394-012-0491-5 CrossRefPubMed

28.

Wang Y, Yang M, Lee SG, Davis CG, Koo SI, Chun OK (2012) Dietary total antioxidant capacity is associated with diet and plasma antioxidant status in healthy young adults. J Acad Nutr Diet 112:1626–1635. https://doi.org/10.1016/j.jand.2012.06.007 CrossRefPubMed

29.

Hermsdorff HH, Puchau B, Volp AC, Barbosa KB, Bressan J, Zulet M et al (2011) Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults. Nutr Metab (Lond) 8:22. https://doi.org/10.1186/1743-7075-8-59 CrossRef

30.

Zamora-Ros R, Serafini M, Estruch R, Lamuela-Raventós RM, Martínez-González MA, Salas-Salvadó J et al (2013) Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: evidence for a mechanism of antioxidant tuning. Nutr Metab Cardiovasc Dis 23:1167–1174. https://doi.org/10.1016/j.numecd.2012.12.008 CrossRefPubMed

31.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097CrossRefPubMedPubMedCentral

32.

Lorente L, Martín MM, Pérez-Cejas A, Abreu-González P, Ramos L, Argueso M et al (2016) Association between total antioxidant capacity and mortality in ischemic stroke patients. Ann Intensive Care 6:39CrossRefPubMedPubMedCentral

33.

Lorente L, Martín MM, Almeida T, Abreu-González P, Ramos L, Argueso M et al (2015) Total antioxidant capacity is associated with mortality of patients with severe traumatic brain injury. BMC Neurol 15:115CrossRefPubMedPubMedCentral

34.

Sakhi AK, Russnes KM, Thoresen M, Bastani NE, Karlsen A, Smeland S et al (2009) Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study. BMC Cancer 9:458CrossRefPubMedPubMedCentral

35.

Lorente L, Martín MM, Almeida T, Abreu-González P, Ferreres J, Solé-Violán J et al (2015) Association between serum total antioxidant capacity and mortality in severe septic patients. J Crit Care 30:217. e217–217. e212PubMed

36.

Fletcher AE, Breeze E, Shetty PS (2003) Antioxidant vitamins and mortality in older persons: findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community. Am J Clin Nutr 78:999–1010CrossRefPubMed

37.

Rautiainen S, Levitan EB, Orsini N, Åkesson A, Morgenstern R, Mittleman MA et al (2012) Total antioxidant capacity from diet and risk of myocardial infarction: a prospective cohort of women. Am J Med 125:974–980CrossRefPubMed

38.

Rautiainen S, Larsson S, Virtamo J, Wolk A (2012) Total antioxidant capacity of diet and risk of stroke: a population-based prospective cohort of women. Stroke 43:335–340. https://doi.org/10.1161/strokeaha.111.635557 CrossRefPubMed

39.

Lucas AL, Bosetti C, Boffetta P, Negri E, Tavani A, Serafini M et al (2016) Dietary total antioxidant capacity and pancreatic cancer risk: an Italian case–control study. Br J Cancer 115:102–107. https://doi.org/10.1038/bjc.2016.114 CrossRefPubMedPubMedCentral

40.

Vance TM, Wang Y, Su LJ, Fontham ET, Steck SE, Arab L et al (2016) Dietary total antioxidant capacity is inversely associated with prostate cancer aggressiveness in a population-based study. Nutr Cancer 68:214–224. https://doi.org/10.1080/01635581.2016.1134596 CrossRefPubMedPubMedCentral

41.

Del Rio D, Agnoli C, Pellegrini N, Krogh V, Brighenti F, Mazzeo T et al (2011) Total antioxidant capacity of the diet is associated with lower risk of ischemic stroke in a large Italian cohort. J Nutr 141:118–123. https://doi.org/10.3945/jn.110.125120 CrossRefPubMed

42.

Rautiainen S, Levitan EB, Mittleman MA, Wolk A (2013) Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 126:494–500CrossRefPubMed

43.

Wells G, Shea B, O’connell D, Peterson J, Welch V, Losos M et al (2015) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute; 2011. oxford. asp

44.

Green S, Higgins J (eds) (2008) The Cochrane handbook for systematic reviews of interventions. Wiley, Chichester

45.

Greenland S, Longnecker MP (1992) Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 135:1301–1309CrossRefPubMed

46.

Orsini N, Bellocco R, Greenland S (2006) Generalized least squares for trend estimation of summarized dose-response data. Stat J 6:40CrossRef

47.

Harre FE Jr, Lee KL, Pollock BG (1988) Regression models in clinical studies: determining relationships between predictors and response. JNCI 80:1198–1202CrossRef

48.

Jackson D, White IR, Thompson SG (2010) Extending DerSimonian and Laird’s methodology to perform multivariate random effects meta-analyses. Stat Med 29:1282–1297CrossRefPubMed

49.

Berlin JA, Longnecker MP, Greenland S (1993) Meta-analysis of epidemiologic dose-response data. Epidemiology 4:218–228CrossRef

50.

Wong MCS, Fung FDH, Leung C, Cheung WWL, Goggins WB, Ng CF (2018) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projection. Sci Rep 8:1129. https://doi.org/10.1038/s41598-018-19199-z CrossRefPubMedPubMedCentral

51.

Andersson C, Vasan RS (2017) Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. https://doi.org/10.1038/nrcardio.2017.154 CrossRefPubMed

52.

Kwasny C, Manuwald U, Kugler J, Rothe U (2017) systematic review of the epidemiology and natural history of the metabolic vascular syndrome and its coincidence with type 2 diabetes mellitus and cardiovascular diseases in different European countries. Horm Metab Res. https://doi.org/10.1055/s-0043-122395 CrossRefPubMed

53.

Uppal S, Al-Kindi SG, Oliveira GH (2018) Cardiovascular mortality among 76 864 survivors of childhood cancers in the United States: a report from the surveillance, epidemiology, and end-results program. J Cardiovasc Med (Hagerstown) 19:38–41. https://doi.org/10.2459/jcm.0000000000000585 CrossRef

54.

Benisi-Kohansal S, Saneei P, Salehi-Marzijarani M, Larijani B, Esmaillzadeh A (2016) Whole-grain intake and mortality from all causes, cardiovascular disease, and cancer: a systematic review and dose-response meta-analysis of prospective cohort studies. Adv Nutr 7:1052–1065. https://doi.org/10.3945/an.115.011635 CrossRefPubMedPubMedCentral

55.

Wang JB, Fan JH, Dawsey SM, Sinha R, Freedman ND, Taylor PR et al (2016) Dietary components and risk of total, cancer and cardiovascular disease mortality in the Linxian Nutrition Intervention Trials cohort in China. Sci Rep 6:22619. https://doi.org/10.1038/srep22619 CrossRefPubMedPubMedCentral

56.

Pantavos A, Ruiter R, Feskens EF, de Keyser CE, Hofman A, Stricker BH et al (2015) Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study. Int J Cancer 136:2178–2186. https://doi.org/10.1002/ijc.29249 CrossRefPubMed

57.

Serafini M, Jakszyn P, Lujan-Barroso L, Agudo A, Bas Bueno-de-Mesquita H, van Duijnhoven FJ et al (2012) Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer 131:E544–E554. https://doi.org/10.1002/ijc.27347 CrossRefPubMed

58.

Schwingshackl L, Hoffmann G (2014) Adherence to Mediterranean diet and risk of cancer: a systematic review and meta-analysis of observational studies. Int J Cancer 135:1884–1897. https://doi.org/10.1002/ijc.28824 CrossRefPubMed

59.

Perez-Jimenez J, Diaz-Rubio ME, Saura-Calixto F (2015) Contribution of macromolecular antioxidants to dietary antioxidant capacity: a study in the Spanish mediterranean diet. Plant Foods Hum Nutr 70:365–370. https://doi.org/10.1007/s11130-015-0513-6 CrossRefPubMed

60.

Chang ET, Lee VS, Canchola AJ, Clarke CA, Purdie DM, Reynolds P et al (2007) Diet and risk of ovarian cancer in the California Teachers Study cohort. Am J Epidemiol 165:802–813. https://doi.org/10.1093/aje/kwk065 CrossRefPubMed

61.

Vece MM, Agnoli C, Grioni S, Sieri S, Pala V, Pellegrini N et al (2015) Dietary total antioxidant capacity and colorectal cancer in the Italian EPIC cohort. PLoS One 10:e0142995. https://doi.org/10.1371/journal.pone.0142995 CrossRefPubMedPubMedCentral

62.

Kim K, Vance TM, Chun OK (2016) Greater total antioxidant capacity from diet and supplements is associated with a less atherogenic blood profile in US adults. Nutrients 8:15CrossRefPubMedCentral

63.

Yang M, Chung S-J, Floegel A, Song WO, Koo SI, Chun OK (2013) Dietary antioxidant capacity is associated with improved serum antioxidant status and decreased serum C-reactive protein and plasma homocysteine concentrations. Eur J Nutr 52:1901–1911CrossRefPubMed

64.

Franklin SS, Wong ND (2013) Hypertension and cardiovascular disease: contributions of the Framingham Heart Study. Global heart 8:49–57CrossRefPubMed

65.

Vasan RS, Larson MG, Leip EP, Evans JC, O’Donnell CJ, Kannel WB et al (2001) Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 345:1291–1297CrossRefPubMed

66.

Devore EE, Feskens E, Ikram MA, den Heijer T, Vernooij M, van der Lijn F et al (2013) Total antioxidant capacity of the diet and major neurologic outcomes in older adults. Neurology 80:904–910. https://doi.org/10.1212/WNL.0b013e3182840c84 CrossRefPubMedPubMedCentral

67.

Stefanson AL, Bakovic M (2014) Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals. Nutrients 6:3777–3801. https://doi.org/10.3390/nu6093777 CrossRefPubMedPubMedCentral

68.

Kim Y, Je Y (2014) Dietary fiber intake and total mortality: a meta-analysis of prospective cohort studies. Am J Epidemiol 180:565–573. https://doi.org/10.1093/aje/kwu174 CrossRefPubMed

Titel: Dietary total antioxidant capacity and mortality from all causes, cardiovascular disease and cancer: a systematic review and dose–response meta-analysis of prospective cohort studies
verfasst von: Mohammad Parohan
Javad Anjom-Shoae
Morteza Nasiri
Mahmoud Khodadost
Seyed Reza Khatibi
Omid Sadeghi
Publikationsdatum: 11.02.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-01922-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2019

Acute and residual effects of aerobic exercise on fructose-induced postprandial lipemia on lean male subjects

Potatoes and risk of chronic disease: a systematic review and dose–response meta-analysis

Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin–nicotinamide-induced diabetic rats

High intake of dietary fibre from fruit and vegetables reduces the risk of hospitalisation for diverticular disease

A cross-sectional study of fatty acids and brain-derived neurotrophic factor (BDNF) in human milk from lactating women following vegan, vegetarian, and omnivore diets