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01.02.2014 | Original Article

Diffusional kurtosis imaging analysis in patients with hypertension

verfasst von: Keigo Shimoji, Takanori Uka, Yoshifumi Tamura, Mariko Yoshida, Koji Kamagata, Masaaki Hori, Yumiko Motoi, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki

Erschienen in: Japanese Journal of Radiology | Ausgabe 2/2014

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Abstract

Purpose

Hypertension is associated with substantial morbidity in Japan. The aim of this work was to evaluate whether hypertension is associated with white matter microstructural changes by using diffusional kurtosis imaging (DKI).

Methods

We explored the regional patterns of white matter alteration in 15 hypertensive middle-aged male participants and 11 normotensive controls by using DKI-based whole-brain analysis. In addition, we investigated whether the observed white matter microstructural changes were related to systolic or diastolic blood pressure by using Pearson’s correlation coefficient analysis.

Results

Mean diffusional kurtosis (MDK) values were significantly higher in hypertensive participants than in normotensive participants (P < 0.05; family-wise error correction for multiple comparisons), indicating widespread microstructural changes in white matter. Moreover, we noted a statistically significant positive correlation between systolic and diastolic blood pressure and MDK values of the whole brain.

Conclusion

Our study suggests that microstructural white matter changes occur in middle-aged men with hypertension, even before the onset of cerebrovascular disease. Thus, DKI might be used as a screening tool for risk of cerebrovascular disease. This highlights the need to further elucidate the relationship between hypertension and DKI of the brain.

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Titel: Diffusional kurtosis imaging analysis in patients with hypertension
verfasst von: Keigo Shimoji
Takanori Uka
Yoshifumi Tamura
Mariko Yoshida
Koji Kamagata
Masaaki Hori
Yumiko Motoi
Hirotaka Watada
Ryuzo Kawamori
Shigeki Aoki
Publikationsdatum: 01.02.2014
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 2/2014
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-013-0275-8

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Diffusional kurtosis imaging analysis in patients with hypertension