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Neurological Sciences

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27.03.2020 | Original Article

Does M1 anodal transcranial direct current stimulation affects online and offline motor learning in patients with multiple sclerosis?

verfasst von: Nooshin Masoudian, Fatemeh Ehsani, Monireh Nazari, Maryam Zoghi, Shapour Jaberzadeh

Erschienen in: Neurological Sciences | Ausgabe 9/2020

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Abstract

Objective

Multiple Sclerosis (MS) is one of the most common neurological diseases in the world. Due to structural and functional changes in central nerves system, the patients with MS may affected by sensory-motor learning deficits. The aims of the current study was to assess the effect of primary motor cortex (M1) anodal transcranial direct current stimulation (a-tDCS) on online and offline motor learning in patients with MS.

Materials and methods

Thirty-nine patients with MS were randomly assigned in three groups: concurrent M1 a-tDCS and serial response time test (SRTT) (n=13), concurrent sham a-tDCS and SRTT (n=13) and SRTT-only control (n=13). The participants in all groups were asked to concurrently perform 20 minutes of SRTT. M1 a-tDCS group received 20-minute M1 a-tDCS (2 mA) concurrent with SRTT, while the a-tDCS was turned off after 30 seconds in the sham a-tDCS group. Response time (RT) and error rate (ER) during SRTT were assessed prior, during and 48 hours after the intervention.

Results

Online learning happened in all groups (P < 0.05), with more significant learning in M1 a-tDCS group as compared to the other groups (P < 0.05). However, offline learning was occurred only in M1 a-tDCS group (P < 0.05).

Conclusions

The findings indicate offline motor learning impairment in patients with MS. M1 a-tDCS may be used for enhancement of motor learning especially offline learning in patients with MS.

Stadelmann C, Wegner C, Brück W (2011) Inflammation, demyelination, and degeneration—recent insights from MS pathology. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1812:275–282CrossRef

Harbo HF, Gold R, Tintoré M (2013) Sex and gender issues in multiple sclerosis. Therapeutic advances in neurological disorders 6:237–248PubMedPubMedCentralCrossRef

Etemadifar M, Izadi S, Nikseresht A, Sharifian M, Sahraian MA, Nasr Z (2014) Estimated prevalence and incidence of multiple sclerosis in Iran. European neurology 72:370–374PubMedCrossRef

Ksiazek-Winiarek DJ, Szpakowski P, Glabinski A (2015) Neural plasticity in multiple sclerosis: the functional and molecular background. Neural plasticity

X-m H, H-j T, Han Z, Zhang C, Liu Y, Gu J-b et al (2017) Correlation between white matter damage and gray matter lesions in multiple sclerosis patients. Neural regeneration research 12:787CrossRef

Rocca MA, Absinta M, Moiola L, Ghezzi A, Colombo B, Martinelli V, Comi G, Filippi M (2010) Functional and structural connectivity of the motor network in pediatric and adult-onset relapsing-remitting multiple sclerosis. Radiology. 254:541–550PubMedCrossRef

Gorgoraptis N, Wheeler-Kingshott CA, Jenkins TM, Altmann DR, Miller DH, Thompson AJ et al (2010) Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis. Multiple Sclerosis Journal 16:555–565PubMedCrossRef

Zahiri N, Abollahi I, Nabavi SM, Ehsani F, Arab AM, Shaw I, et al (2017). Interference effect of prior explicit information on motor sequence learning in relapsing-remitting multiple sclerosis patients. The Malaysian journal of medical sciences: MJMS. 24:69

Jimenez JJ, Yang R, Nathoo N, Varshney VP, Golestani A-M, Goodyear BG, et al (2014). Detection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopy. Journal of biomedical optics.19:076008

10.

Fling BW, Dutta GG, Horak FB (2015) Functional connectivity underlying postural motor adaptation in people with multiple sclerosis. NeuroImage: Clinical 8:281–289CrossRef

11.

Rogers KA, MacDonald M (2015) Therapeutic yoga: symptom management for multiple sclerosis. J Altern Complement Med 21:655–659PubMedPubMedCentralCrossRef

12.

De Stefano N, Airas L, Grigoriadis N, Mattle HP, O’Riordan J, Oreja-Guevara C et al (2014) Clinical relevance of brain volume measures in multiple sclerosis. CNS Drugs 28:147–156PubMedCrossRef

13.

Giorgio A, De Stefano N (2016) Advanced structural and functional brain MRI in multiple sclerosis. Thieme Medical Publishers, Seminars in neurologyCrossRef

14.

Boggio PS, Castro LO, Savagim EA, Braite R, Cruz VC, Rocha RR, Rigonatti SP, Silva MT, Fregni F (2006) Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation. Neurosci Lett 404:232–236PubMedCrossRef

15.

Hunter T, Sacco P, Nitsche MA, Turner DL (2009) Modulation of internal model formation during force field-induced motor learning by anodal transcranial direct current stimulation of primary motor cortex. J Physiol 587:2949–2961PubMedPubMedCentralCrossRef

16.

Hummel FC, Cohen LG (2006) Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? The Lancet Neurology 5:708–712PubMedCrossRef

17.

Hummel F, Celnik P, Giraux P, Floel A, Wu W-H, Gerloff C, Cohen LG (2005) Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain. 128:490–499PubMedCrossRef

18.

Fregni F, Boggio PS, Santos MC, Lima M, Vieira AL, Rigonatti SP, Silva MT, Barbosa ER, Nitsche MA, Pascual-Leone A (2006) Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease. Mov Disord 21:1693–1702PubMedCrossRef

19.

Rumpf J-J, Dietrich S, Stoppe M, Fricke C, Weise D, Bergh FT et al (2018) Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis. J Neurol 265:2302–2311PubMedCrossRef

20.

Kuo M-F, Unger M, Liebetanz D, Lang N, Tergau F, Paulus W, Nitsche MA (2008) Limited impact of homeostatic plasticity on motor learning in humans. Neuropsychologia. 46:2122–2128PubMedCrossRef

21.

Stagg C, Jayaram G, Pastor D, Kincses Z, Matthews P, Johansen-Berg H (2011) Polarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning. Neuropsychologia. 49:800–804PubMedPubMedCentralCrossRef

22.

Ehsani F, Bakhtiary A, Jaberzadeh S, Talimkhani A, Hajihasani A (2016) Differential effects of primary motor cortex and cerebellar transcranial direct current stimulation on motor learning in healthy individuals: a randomized double-blind sham-controlled study. Neurosci Res 112:10–19PubMedCrossRef

23.

McGowan K, Gunn SM, Vorobeychik G, Marigold DS (2017) Short-term motor learning and retention during visually guided walking in persons with multiple sclerosis. Neurorehabil Neural Repair 31:648–656PubMedCrossRef

24.

Light LL, Singh A (1987). Implicit and explicit memory in young and older adults. Journal of experimental psychology: learning, memory, and Cognition. 13:531

25.

Ferrucci R, Brunoni AR, Parazzini M, Vergari M, Rossi E, Fumagalli M, Mameli F, Rosa M, Giannicola G, Zago S, Priori A (2013) Modulating human procedural learning by cerebellar transcranial direct current stimulation. Cerebellum 12:485–492PubMedCrossRef

26.

Ehsani F, Abdollahi I, Bandpei MAM, Zahiri N, Jaberzadeh S (2015). Motor learning and movement performance: older versus younger adults. Basic and clinical neuroscience. 6:231

27.

Nissen MJ, Bullemer P (1987) Attentional requirements of learning: evidence from performance measures. Cogn Psychol 19:1–32CrossRef

28.

Reis J, Schambra HM, Cohen LG, Buch ER, Fritsch B, Zarahn E et al (2009) Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. Proceedings of the National Academy of Sciences 106:1590–1595CrossRef

29.

Galea JM, Vazquez A, Pasricha N, Orban de Xivry J-J, Celnik P (2010) Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns. Cereb Cortex 21:1761–1770PubMedPubMedCentralCrossRef

30.

Ambrus GG, Al-Moyed H, Chaieb L, Sarp L, Antal A, Paulus W (2012) The fade-in-short stimulation-fade out approach to sham tDCS-reliable at 1 mA for naïve and experienced subjects, but not investigators. Brain Stimul 5(4):499–504PubMedCrossRef

31.

Hardwick RM, Celnik PA (2014) Cerebellar direct current stimulation enhances motor learning in older adults. Neurobiol Aging 35:2217–2221PubMedPubMedCentralCrossRef

32.

George MS, Aston-Jones G (2010) Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Neuropsychopharmacology. 35:301–316PubMedCrossRef

33.

Nitsche MA, Cohen LG, Wassermann EM, Priori A, Lang N, Antal A et al (2008) Transcranial direct current stimulation: state of the art 2008. Brain stimulation 1:206–223PubMedCrossRef

34.

Tacchino A, Bove M, Roccatagliata L, Mancardi GL, Uccelli A, Bonzano L (2014) Selective impairments of motor sequence learning in multiple sclerosis patients with minimal disability. Brain Res 1585:91–98PubMedCrossRef

35.

Sarabandi M (2017) A comparison of implicit and explicit motor sequence learning in patients with relapsing-remitting multiple sclerosis. Sports. 5:34PubMedCentralCrossRef

36.

Tomassini V, Johansen-Berg H, Leonardi L, Paixao L, Jbabdi S, Palace J et al (2011) Preservation of motor skill learning in patients with multiple sclerosis. Mult Scler J 17:103–115CrossRef

37.

Hamoudi M, Schambra HM, Fritsch B, Schoechlin-Marx A, Weiller C, Cohen LG, Reis J (2018) Transcranial direct current stimulation enhances motor skill learning but not generalization in chronic stroke. Neurorehabil Neural Repair 32:295–308PubMedPubMedCentralCrossRef

38.

Choe J, Coffman BA, Bergstedt DT, Ziegler MD, Phillips ME (2016). Transcranial direct current stimulation modulates neuronal activity and learning in pilot training. Frontiers in human neuroscience 10:34

39.

D'esposito M, Onishi K, Thompson H, Robinson K, Armstrong C, Grossman M (1996) Working memory impairments in multiple sclerosis: evidence from a dual-task paradigm. Neuropsychology 10:51CrossRef

40.

De Xivry J-jO, Shadmehr R (2014) Electrifying the motor engram: effects of tDCS on motor learning and control. Exp Brain Res 232:3379–3395PubMedCentralCrossRef

41.

Herzfeld DJ, Pastor D, Haith AM, Rossetti Y, Shadmehr R, O'shea J (2014) Contributions of the cerebellum and the motor cortex to acquisition and retention of motor memories. Neuroimage. 98:147–158PubMedPubMedCentralCrossRef

42.

Santarnecchi E, Feurra M, Barneschi F, Acampa M, Bianco G, Cioncoloni D, Rossi A, Rossi S (2014) Time course of Corticospinal excitability and autonomic function interplay during and following Monopolar tDCS. Front Psychiatry 5:86PubMedPubMedCentralCrossRef

Titel: Does M1 anodal transcranial direct current stimulation affects online and offline motor learning in patients with multiple sclerosis?
verfasst von: Nooshin Masoudian
Fatemeh Ehsani
Monireh Nazari
Maryam Zoghi
Shapour Jaberzadeh
Publikationsdatum: 27.03.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 9/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04359-9

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Does M1 anodal transcranial direct current stimulation affects online and offline motor learning in patients with multiple sclerosis?

Abstract

Objective

Materials and methods

Results

Conclusions

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Update Neurologie

Springer Medizin

Abstract

Objective

Materials and methods

Results

Conclusions

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