nach oben

Erschienen in:

01.03.2016 | Original Article

Effect of Nutrition Supplementation in Children Living with HIV at ART Centre

verfasst von: Himabindu Singh Thakur, Geetha Srivalliswari Gottapu, Sai Prasad Kadali, Bharati Kulkarni, Raja Sriswan Mamidi

Erschienen in: Indian Journal of Pediatrics | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

Objective

To assess the benefits of nutrition supplementation in children living with HIV (CLHIV).

Methods

A prospective observational study was carried out at antiretroviral therapy (ART)/pediatric centre of excellence (PCOE), Niloufer hospital for a period of one year in CLHIV (N = 164) aged 1 to 18 y referred to ART/PCOE. Nutrition supplementation was given in the form of Ready to Use Food (About 350 kcal and 12 g of protein per day) supplementation to assess improvement in Height for age Z (HAZ), Weight for Age Z (WAZ), Weight for Height Z (WHZ) and Body Mass Index for age Z (BMIZ) scores over a period of one year.

Results

At baseline, 65.5 % and 57.5 % of children below and above 5 y respectively were stunted. 24.1 % and 45.3 % children below and above 5 y respectively were wasted/thin (as assessed by BMI for age). Mean BMIZ score significantly improved in both the age groups (0.96 Z score, P < 0.001) in below and above 5 (0.37 Z score, P < 0.001) respectively at the end of 12 mo. Mean HAZ score also significantly improved in children above 5 y (0.09 Z score, P < 0.05) with non-significant improvement below 5 y (0.14 Z score, P < 0.57) by the end of 12 mo.

Conclusions

Nutrition supplementation over one year resulted in moderate improvement in the nutritional status of CLHIV. However, it is unclear, whether the improvement in nutritional status was due to regular visits to ART centre that may have resulted in better adherence to treatment or an additional benefit of nutrition intervention. This warrants a well-designed randomized controlled trial to examine the benefits of nutrition supplementation in CLHIV attending ART centre.

WHO. Key facts on HIV epidemic and progress in regions and countries in 2010. In: WHO. Available at: http://wwwwhoint/hiv/pub/progress_report2011/regional_facts/en/index1html. Accessed on 27 Apr 2014.

National Family Health Survey (NFHS-3). Mumbai: International Institute for Population Sciences; 2007.

Babameto G, Kotler DP. Malnutrition in HIV infection. Gastroenterol Clin North Am. 1997;26:393–415.CrossRefPubMed

Macallan DC, Noble C, Baldwin C, et al. Energy expenditure and wasting in human immunodeficiency virus infection. N Engl J Med. 1995;333:83–8.CrossRefPubMed

Rose AM, Hall CS, Martinez-Alier N. Aetiology and management of malnutrition in HIV-positive children. Arch Dis Child. 2014;30:33–48.

Stringer JSA, Zulu I, Levy J, et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA. 2006;296:782–93.CrossRefPubMed

Zachariah R, Fitzgerald M, Massaquoi M, et al. Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. AIDS. 2006;20:2355–60.CrossRefPubMed

World Health Organization. Nutrition requirements for people living with HIV/AIDS: Report of a technical consultation. Geneva: WHO; 2003.

WHO. Description. Available at: http://www.who.int/nutgrowthdb/about/introduction/en/index5.html. Accessed on 21 Apr 2015.

10.

Mda S, van Raaij JMA, MacIntyre UE, de Villiers FPR, Kok FJ. Duration of hospitalization and appetite of HIV-infected South African children. Matern Child Nutr. 2011;7:175–87.CrossRefPubMed

11.

Kosmiski L Energy expenditure in HIV infection. Am J Clin Nutr. 2011;94:1677S–82.PubMedCentralCrossRefPubMed

12.

Villamor E, Mbise R, Spiegelman D, et al. Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth. Pediatrics. 2002;109:E6.

13.

Coutsoudis A, Bobat RA, Coovadia HM, Kuhn L, Tsai WY, Stein ZA. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. Am J Public Health. 1995;85:1076–81.PubMedCentralCrossRefPubMed

14.

Srinivasan MG, Ndeezi G, Mboijana CK, et al. Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial. BMC Med. 2012;10:14.PubMedCentralCrossRefPubMed

15.

Irlam JH, Siegfried N, Visser ME, Rollins NC. Micronutrient supplementation for children with HIV infection. Cochrane Database Syst Rev. 2013;10:CD010666.

16.

Sunguya BF, Poudel KC, Mlunde LB, et al. Ready to Use Therapeutic Foods (RUTF) improves undernutrition among ART-treated, HIV-positive children in Dar es Salaam. Tanzania Nutr J. 2012;11:60.PubMed

17.

Bhutta ZA, Ahmed T, Black RE, et al. What works? Interventions for maternal and child undernutrition and survival. Lancet. 2008;371:417–40.CrossRefPubMed

Titel: Effect of Nutrition Supplementation in Children Living with HIV at ART Centre
verfasst von: Himabindu Singh Thakur
Geetha Srivalliswari Gottapu
Sai Prasad Kadali
Bharati Kulkarni
Raja Sriswan Mamidi
Publikationsdatum: 01.03.2016
Verlag: Springer India
Erschienen in: Indian Journal of Pediatrics / Ausgabe 3/2016
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-015-1873-5

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Effect of Nutrition Supplementation in Children Living with HIV at ART Centre