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Journal of NeuroVirology

Erschienen in:

19.12.2017

Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats

verfasst von: Jianlin He, Wenfei Huang, Shizhong Zheng, Michael Vigorito, Sulie L. Chang

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2018

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Abstract

Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients receiving combination anti-retroviral therapy (cART). Docosahexaenoic acid (DHA) is a marine compound that modulates inflammatory responses. Using HIV-1Tg rats subjected to binge exposure to ethanol (EtOH), this study examined whether DHA could reduce the detrimental neurological effects of EtOH and HIV proteins. Young adult male HIV-1Tg and F344 control rats received 4 mL/kg/day saline as a control (Saline group), 20 mg/kg/day DHA (DHA group), 4.8 g/kg/day 52% w/v EtOH (EtOH group), or 4.8 g/kg/day 52% w/v EtOH and 20 mg/kg/d DHA (DHA + EtOH group) by gavage for 5 weeks (n = 6 per group). EtOH was administrated on days 5, 6, and 7 of each week. Locomotor activity (LMA) was assessed using open field tests before and 45, 90, 135, and 180 min after each treatment. Repeated binge EtOH exposure gradually decreased LMA measured before daily treatments in HIV-1Tg and F344 rats, an effect that was reversed by DHA only in the HIV-1Tg rats. Decreased LMA of rats after treatment and under the influence of EtOH was less pronounced, and the reversal effect of DHA did not reach statistical significance. The plasma endotoxin level was significantly higher in HIV-1Tg rats than in F344 rats. IL-6 and IL-18 expression in the striatum was significantly higher in the HIV-1Tg EtOH group than in the F344 EtOH group. DHA significantly decreased the high levels of IL-6, IL-18, and NF-κB expression observed in the HIV-1Tg EtOH group. DHA appears to ameliorate inflammation and consequently lessen the reductions in LMA produced by the combination of EtOH and HIV-1 viral proteins.

Aarli JA (2003) Role of cytokines in neurological disorders. Curr Med Chem 10:1931–1937CrossRefPubMed

Abbondanzo SJ, Chang SL (2014) HIV-1 transgenic rats display alterations in immunophenotype and cellular responses associated with aging. PLoS One 9:e105256CrossRefPubMedPubMedCentral

Acheampong E, Mukhtar M, Parveen Z, Ngoubilly N, Ahmad N, Patel C, Pomerantz RJ (2002) Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells. Virology 304:222–234CrossRefPubMed

Ahmad R, Sindhu ST, Toma E, Morisset R, Ahmad A (2002) Elevated levels of circulating interleukin-18 in human immunodeficiency virus-infected individuals: role of peripheral blood mononuclear cells and implications for AIDS pathogenesis. J Virol 76:12448–12456CrossRefPubMedPubMedCentral

Alboni S, Cervia D, Sugama S, Conti B (2010) Interleukin 18 in the CNS. J Neuroinflammation 7:9CrossRefPubMedPubMedCentral

Alfonso-Loeches S, Urena-Peralta J, Morillo-Bargues MJ, Gomez-Pinedo U, Guerri C (2016) Ethanol-induced TLR4/NLRP3 Neuroinflammatory response in microglial cells promotes leukocyte infiltration across the BBB. Neurochem Res 41:193–209CrossRefPubMed

Anderson GJ, Connor WE, Corliss JD (1990) Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. Pediatr Res 27:89–97CrossRefPubMed

Baez-Mendoza R, Schultz W (2013) The role of the striatum in social behavior. Front Neurosci 7:233CrossRefPubMedPubMedCentral

Banks WA, Kastin AJ, Brennan JM, Vallance KL (1999) Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp Neurol 156:165–171CrossRefPubMed

Bie B, Wang Y, Cai YQ, Zhang Z, Hou YY, Pan ZZ (2012) Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward. Neuropsychopharmacology 37:2780–2788CrossRefPubMedPubMedCentral

Bjarnason I, Peters TJ, Wise RJ (1984) The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1:179–182CrossRefPubMed

Burdge GC, Jones AE, Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr 88:355–363CrossRefPubMed

Burdge GC, Wootton SA (2002) Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88:411–420CrossRefPubMed

Cardoso C, Afonso C, Bandarra NM (2016) Dietary DHA and health: cognitive function ageing. Nutr Res Rev 29:281–294CrossRefPubMed

Chang SL, Connaghan KP, Wei Y, Li MD (2014) NeuroHIV and use of addictive substances. Int Rev Neurobiol 118:403–440CrossRefPubMed

Covacu R, Brundin L (2015). Effects of neuroinflammation on neural stem cells. Neuroscientist

Crews FT, Vetreno RP (2016) Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacology 233:1543–1557CrossRefPubMed

Davoren MP, Demant J, Shiely F, Perry IJ (2016) Alcohol consumption among university students in Ireland and the United Kingdom from 2002 to 2014: a systematic review. BMC Public Health 16:173CrossRefPubMedPubMedCentral

Del Corno M, Donninelli G, Varano B, Da Sacco L, Masotti A, Gessani S (2014). HIV-1 gp120 activates the STAT3/interleukin-6 axis in primary human monocyte-derived dendritic cells. J Virol 88: 11045–11055

Dohgu S, Banks WA (2008) Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp Neurol 210:740–749CrossRefPubMedPubMedCentral

Doremus-Fitzwater TL, Gano A, Paniccia JE, Deak T (2015) Male adolescent rats display blunted cytokine responses in the CNS after acute ethanol or lipopolysaccharide exposure. Physiol Behav 148:131–144CrossRefPubMedPubMedCentral

Dyall SC (2015) Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci 7:52CrossRefPubMedPubMedCentral

Erta M, Giralt M, Esposito FL, Fernandez-Gayol O, Hidalgo J (2015) Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior. Horm Behav 73:64–74CrossRefPubMed

Erta M, Quintana A, Hidalgo J (2012) Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 8:1254–1266CrossRefPubMedPubMedCentral

Flora G, Pu H, Lee YW, Ravikumar R, Nath A, Hennig B, Toborek M (2005) Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue. Exp Neurol 191:2–12CrossRefPubMed

Gano A, Doremus-Fitzwater TL, Deak T (2016) Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure. Brain Res 1646:62–72CrossRefPubMedPubMedCentral

Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL (2004) Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr 80:1167–1174PubMed

Grillner S, Hellgren J, Menard A, Saitoh K, Wikstrom MA (2005) Mechanisms for selection of basic motor programs—roles for the striatum and pallidum. Trends Neurosci 28:364–370CrossRefPubMed

Hong H, Kim BS, Im HI (2016) Pathophysiological role of neuroinflammation in neurodegenerative diseases and psychiatric disorders. Int Neurourol J 20:S2–S7CrossRefPubMedPubMedCentral

Hsu K (2009) Long-chain polyunsaturated fatty acids as anti-HIV supplementation during breastfeeding. Taiwan J Obstet Gynecol 48:65–68CrossRefPubMed

Iannello A, Samarani S, Debbeche O, Tremblay C, Toma E, Boulassel MR, Routy JP, Ahmad A (2009) Role of interleukin-18 in the development and pathogenesis of AIDS. AIDS Rev 11:115–125PubMed

Jasani B, Simmer K, Patole SK, Rao SC (2017) Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 3:CD000376PubMed

Johnston LD, O’Malley PM, Miech RA, Bachman JG, Schulenberg JE (2014) Monitoring the future national results on drug use: 1975–2013: overview. Findings on Adolescent Drug Use, Key

Kanmogne GD, Primeaux C, Grammas P (2005) HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia. J Neuropathol Exp Neurol 64:498–505CrossRefPubMed

Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H (2009) Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep 58(RR-4):1–207

Kiehn O, Dougherty K (2013). Locomotion: circuits and physiology. Springer New York

Kim CS, Ross IA, Sapienza PP, Hanes DE, Johnson W, Hutter JC (2014) Distribution and pharmacokinetics of double-radiolabeled endotoxin in the rat brain and peripheral organs. Toxicol Ind Health 30:432–441CrossRefPubMed

Lauritzen L, Brambilla P, Mazzocchi A, Harslof LB, Ciappolino V, Agostoni C (2016) DHA effects in brain development and function. Nutrients 8

Libermann TA, Baltimore D (1990) Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10:2327–2334CrossRefPubMedPubMedCentral

Liu X, Kumar A (2015) Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes. Sci Rep 5:9867CrossRefPubMedPubMedCentral

McRae M (2016) HIV and viral protein effects on the blood brain barrier. Tissue Barriers 4:e1143543CrossRefPubMedPubMedCentral

Menard CR, Goodman KJ, Corso TN, Brenna JT, Cunnane SC (1998) Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. J Neurochem 71:2151–2158CrossRefPubMed

Meng ZH, Pennington SN, Dar MS (1998) Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP. Neuroscience 85:919–930CrossRefPubMed

Nair M, Maria JM, Agudelo M, Yndart A, Vargas-Rivera ME (2015) Platelets contribute to BBB disruption induced by HIV and alcohol. J Alcohol Drug Depend 3:182PubMedPubMedCentral

Nookala AR, Kumar A (2014) Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes. J Neuroinflammation 11:214CrossRefPubMedPubMedCentral

Otto SJ, van Houwelingen AC, Badart-Smook A, Hornstra G (2001) Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. Am J Clin Nutr 73:302–307PubMed

Pall ML, Levine S (2015) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Sheng Li Xue Bao 67:1–18PubMed

Park G, Lee SH, Oh DS, Kim YU (2017). Melatonin inhibits neuronal dysfunction-associated with neuroinflammation by atopic psychological stress in NC/Nga atopic-like mouse models. J Pineal Res

Peng J, Vigorito M, Liu X, Zhou D, Wu X, Chang SL (2010) The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART. J Neuroimmunol 218:94–101CrossRefPubMed

Pociecha K, Przejczowska-Pomierny K, Cios A, Wyska E (2015) Contemporary concepts in studies on cyclic AMP and its role in the inflammatory reaction. Postepy Hig Med Dosw (Online) 69:777–798CrossRef

Postle AD, Al MD, Burdge GC, Hornstra G (1995) The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy. Early Hum Dev 43:47–58CrossRefPubMed

Prendergast MA, Little HJ (2007) Adolescence, glucocorticoids and alcohol. Pharmacol Biochem Behav 86:234–245CrossRefPubMed

Prinz M, Hanisch UK (1999) Murine microglial cells produce and respond to interleukin-18. J Neurochem 72:2215–2218CrossRefPubMed

Ranki A, Nyberg M, Ovod V, Haltia M, Elovaara I, Raininko R, Haapasalo H, Krohn K (1995) Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 9:1001–1008CrossRefPubMed

Reid W, Sadowska M, Denaro F, Rao S, Foulke J, Jr., Hayes N, Jones O, Doodnauth D, Davis H, Sill A, O'Driscoll P, Huso D, Fouts T, Lewis G, Hill M, Kamin-Lewis R, Wei C, Ray P, Gallo RC, Reitz M, Bryant J (2001). An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc Natl Acad Sci U S A 98: 9271–9276

Rostasy K, Monti L, Yiannoutsos C, Wu J, Bell J, Hedreen J, Navia BA (2000) NFkappaB activation, TNF-alpha expression, and apoptosis in the AIDS-dementia-complex. J Neuro-Oncol 6:537–543

Sanhueza C, Garcia-Moreno LM, Exposito J (2011) Weekend alcoholism in youth and neurocognitive aging. Psicothema 23:209–214PubMed

Shiu C, Barbier E, Di Cello F, Choi HJ, Stins M (2007). HIV-1 gp120 as well as alcohol affect blood-brain barrier permeability and stress fiber formation: involvement of reactive oxygen species. Alcohol Clin Exp Res 31: 130–137

Shu J, Zhang F, Zhang L, Wei W (2016). G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis. Inflamm Res

Siegel M, DeJong W, Naimi TS, Fortunato EK, Albers AB, Heeren T, Rosenbloom DL, Ross C, Ostroff J, Rodkin S, King C, Borzekowski DL, Rimal RN, Padon AA, Eck RH, Jernigan DH (2013) Brand-specific consumption of alcohol among underage youth in the United States. Alcohol Clin Exp Res 37:1195–1203CrossRefPubMedPubMedCentral

Siegel M, Dejong W, Naimi TS, Heeren T, Rosenbloom DL, Ross C, Ostroff J, Jernigan DH (2011) Alcohol brand preferences of underage youth: results from a pilot survey among a national sample. Subst Abus 32:191–201CrossRefPubMedPubMedCentral

Silveri MM (2012) Adolescent brain development and underage drinking in the United States: identifying risks of alcohol use in college populations. Harv Rev Psychiatry 20:189–200CrossRefPubMedPubMedCentral

Simopoulos AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54:438–463CrossRefPubMed

Vigorito M, Connaghan KP, Chang SL (2015) The HIV-1 transgenic rat model of neuroHIV. Brain Behav Immun 48:336–349CrossRefPubMedPubMedCentral

von Giesen HJ, Jander S, Koller H, Arendt G (2004) Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease. J Neuro-Oncol 10:383–386

Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384–388CrossRefPubMed

Wang P, Liu Z, Chen H, Ye N, Cheng X, Zhou J (2017). Exchange proteins directly activated by cAMP (EPACs): emerging therapeutic targets. Bioorg Med Chem Lett

Wrona D (2006) Neural-immune interactions: an integrative view of the bidirectional relationship between the brain and immune systems. J Neuroimmunol 172:38–58CrossRefPubMed

Yang J-Y, Xue X, Tian H, Wang X-X, Dong Y-X, Wang F, Zhao Y-N, Yao X-C, Cui W, C-F W (2014) Role of microglia in ethanol-induced neurodegenerative disease: pathological and behavioral dysfunction at different developmental stages. Pharmacol Ther 144:321–337CrossRefPubMed

Titel: Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats
verfasst von: Jianlin He
Wenfei Huang
Shizhong Zheng
Michael Vigorito
Sulie L. Chang
Publikationsdatum: 19.12.2017
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2018
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0597-x

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Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats

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