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Erschienen in: Der Internist 4/2017

23.02.2017 | Typ-1-Diabetes | Schwerpunkt: Patientenorientierte Versorgung der Zukunft

Endokrinologie als Schnittstelle in der interdisziplinären Inneren Medizin

Veranschaulichung anhand des polyglandulären Autoimmunsyndroms

verfasst von: Prof. Dr. G. J. Kahaly, J. Zimmermann, M. P. Hansen, F. Gundling, F. Popp, M. Welcker

Erschienen in: Die Innere Medizin | Ausgabe 4/2017

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Zusammenfassung

Polyglanduläre Autoimmunsyndrome umfassen verschiedene assoziierte Autoimmunerkrankungen, die klinisch variabel und zeitlich versetzt auftreten können. Rheumatische und/oder gastroenterologische Beschwerden bei Patienten mit Autoimmunendokrinopathien können auf eine zusätzliche rheumatische und/oder gastroenterologisch-hepatologische Autoimmunerkrankung hindeuten. Klinisch relevant sind insbesondere die Erkrankungen Autoimmungastritis, Zöliakie, Autoimmunhepatitis, rheumatoide Arthritis, Sjögren-Syndrom und systemischer Lupus erythematodes. Zusätzlich müssen jedoch unspezifische gastrointestinale und rheumatische Begleitsymptome der bestehenden Autoimmunendokrinopathie erwogen werden. Außerdem sind Erkrankungen des polyglandulären Autoimmunsyndroms, beispielsweise ein Diabetes mellitus Typ 1, gehäuft mit bestimmten gastroenterologischen Erkrankungen wie der bakteriellen Überwucherung assoziiert. Die optimale Versorgung von Patienten mit autoimmunen Systemerkrankungen erfordert eine komplexe differenzialdiagnostische Abklärung und unterstreicht die Bedeutung einer interdisziplinären Zusammenarbeit.
Literatur
1.
Zurück zum Zitat Antonelli A, Delle Sedie A, Fallahi P et al (2006) High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis. J Rheumatol 33:2026–2028PubMed Antonelli A, Delle Sedie A, Fallahi P et al (2006) High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis. J Rheumatol 33:2026–2028PubMed
2.
Zurück zum Zitat Atzeni F, Doria A, Ghirardello A et al (2008) Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value. Autoimmunity 41:111–115CrossRefPubMed Atzeni F, Doria A, Ghirardello A et al (2008) Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value. Autoimmunity 41:111–115CrossRefPubMed
3.
Zurück zum Zitat Barnabe C, Martin B‑J, Ghali WA (2011) Systematic review and meta-analysis: Anti-tumor necrosis factor therapy and cardiovascular events in rheumatoid arthritis. Arthritis Care Res 63:522–529CrossRef Barnabe C, Martin B‑J, Ghali WA (2011) Systematic review and meta-analysis: Anti-tumor necrosis factor therapy and cardiovascular events in rheumatoid arthritis. Arthritis Care Res 63:522–529CrossRef
4.
Zurück zum Zitat Ben-Skowronek I, Michalczyk A, Piekarski R et al (2013) Type III polyglandular autoimmune syndromes in children with type 1 diabetes mellitus. Ann Agric Environ Med 20:140–146PubMed Ben-Skowronek I, Michalczyk A, Piekarski R et al (2013) Type III polyglandular autoimmune syndromes in children with type 1 diabetes mellitus. Ann Agric Environ Med 20:140–146PubMed
5.
Zurück zum Zitat Bender SL, Sherry NA, Masia R (2013) Case 16-2013: A 12-year-old girl with irritability, hypersomnia, and somatic symptoms. N Engl J Med 368:2015–2024CrossRefPubMedPubMedCentral Bender SL, Sherry NA, Masia R (2013) Case 16-2013: A 12-year-old girl with irritability, hypersomnia, and somatic symptoms. N Engl J Med 368:2015–2024CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Betterle C, Zanchetta R (2003) Update on autoimmune polyendocrine syndromes (APS). Acta Biomed 74:9–33PubMed Betterle C, Zanchetta R (2003) Update on autoimmune polyendocrine syndromes (APS). Acta Biomed 74:9–33PubMed
7.
8.
Zurück zum Zitat Biagi F, Campanella J, Soriani A et al (2006) Prevalence of coeliac disease in Italian patients affected by Addison’s disease. Scand J Gastroenterol 41:302–305CrossRefPubMed Biagi F, Campanella J, Soriani A et al (2006) Prevalence of coeliac disease in Italian patients affected by Addison’s disease. Scand J Gastroenterol 41:302–305CrossRefPubMed
9.
10.
Zurück zum Zitat Bliuc D, Nguyen N, Milch V et al (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301:513–521CrossRefPubMed Bliuc D, Nguyen N, Milch V et al (2009) Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 301:513–521CrossRefPubMed
11.
Zurück zum Zitat Bolland MJ, Grey A, Avenell A et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ Open 342. doi:10.1136/bmj.d2040 Bolland MJ, Grey A, Avenell A et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ Open 342. doi:10.​1136/​bmj.​d2040
12.
Zurück zum Zitat Briscoe NK, Mezei MM (2009) Polyglandular autoimmune syndrome type 3 in a patient with ocular myasthenia gravis. Muscle Nerve 40:1064–1065CrossRefPubMed Briscoe NK, Mezei MM (2009) Polyglandular autoimmune syndrome type 3 in a patient with ocular myasthenia gravis. Muscle Nerve 40:1064–1065CrossRefPubMed
13.
Zurück zum Zitat Bundesärztekammer, Bundesvereinigung K, Fachgesellschaften ADWM (2015) Nationale VersorgungsLeitlinie: Neuropathie bei Diabetes im Erwachsenenalter, 1. Aufl. Bundesärztekammer, Bundesvereinigung K, Fachgesellschaften ADWM (2015) Nationale VersorgungsLeitlinie: Neuropathie bei Diabetes im Erwachsenenalter, 1. Aufl.
15.
Zurück zum Zitat Capalbo D, Mazza C, Giordano R et al (2012) Molecular background and genotype-phenotype correlation in autoimmune-polyendocrinopathy-candidiasis-ectodermal-distrophy patients from Campania and in their relatives. J Endocrinol Invest 35:169–173PubMed Capalbo D, Mazza C, Giordano R et al (2012) Molecular background and genotype-phenotype correlation in autoimmune-polyendocrinopathy-candidiasis-ectodermal-distrophy patients from Campania and in their relatives. J Endocrinol Invest 35:169–173PubMed
16.
Zurück zum Zitat Choi H, De Vera M, Krishnan E (2008) Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile. Rheumatology (Oxford) 47:1567–1570CrossRef Choi H, De Vera M, Krishnan E (2008) Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile. Rheumatology (Oxford) 47:1567–1570CrossRef
17.
Zurück zum Zitat Chung W, Lin C, Peng C et al (2013) Rheumatoid arthritis and risk of acute myocardial infarction – a nationwide retrospective cohort study. Int J Cardiol 168:4750–4754CrossRefPubMed Chung W, Lin C, Peng C et al (2013) Rheumatoid arthritis and risk of acute myocardial infarction – a nationwide retrospective cohort study. Int J Cardiol 168:4750–4754CrossRefPubMed
18.
19.
Zurück zum Zitat Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2:119–125CrossRefPubMed Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2:119–125CrossRefPubMed
20.
Zurück zum Zitat Dinis-Ribeiro M, Areia M, Vries ACD et al (2012) Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Endoscopy 44:74–94CrossRefPubMed Dinis-Ribeiro M, Areia M, Vries ACD et al (2012) Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Endoscopy 44:74–94CrossRefPubMed
21.
Zurück zum Zitat Driessche VD (2009) Type 1 diabetes and autoimmune polyglandular syndrom: A clinical review. Neth J Med 67:376–387PubMed Driessche VD (2009) Type 1 diabetes and autoimmune polyglandular syndrom: A clinical review. Neth J Med 67:376–387PubMed
22.
Zurück zum Zitat Duru N, Van Der Goes M, Jacobs J et al (2013) EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis :1905–1913. doi:10.1136/annrheumdis-2013-203249 Duru N, Van Der Goes M, Jacobs J et al (2013) EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis :1905–1913. doi:10.​1136/​annrheumdis-2013-203249
23.
Zurück zum Zitat Dvo (2014) Prophylaxe, Diagnostik und Therapie der Osteoporose bei Männern ab dem 60. Lebensjahr und bei postmenopausalen Frauen. Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e. V Dvo (2014) Prophylaxe, Diagnostik und Therapie der Osteoporose bei Männern ab dem 60. Lebensjahr und bei postmenopausalen Frauen. Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e. V
24.
Zurück zum Zitat Enck P, Rathmann W, Spiekermann M et al (1994) Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Z Gastroenterol 32:637–641PubMed Enck P, Rathmann W, Spiekermann M et al (1994) Prevalence of gastrointestinal symptoms in diabetic patients and non-diabetic subjects. Z Gastroenterol 32:637–641PubMed
25.
Zurück zum Zitat Ennazk L, Mghari GE, Ansari NE (2016) Association of newly diagnosed type 1 diabetes and autoimmune pancreatitis. Endocrinol Diabetes Metab Case Rep 2016:16–0047PubMedPubMedCentral Ennazk L, Mghari GE, Ansari NE (2016) Association of newly diagnosed type 1 diabetes and autoimmune pancreatitis. Endocrinol Diabetes Metab Case Rep 2016:16–0047PubMedPubMedCentral
26.
Zurück zum Zitat Fallahi P, Ferrari SM, Ilariaruffilli et al (2016) The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmun Rev 15:1125–1128CrossRefPubMed Fallahi P, Ferrari SM, Ilariaruffilli et al (2016) The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmun Rev 15:1125–1128CrossRefPubMed
27.
Zurück zum Zitat Farkas K, Nagy F, Kovács L et al (2010) Ulcerative colitis and primary sclerosing cholangitis as part of autoimmune polyglandular syndrome type III. Inflamm Bowel Dis 16:10–11CrossRefPubMed Farkas K, Nagy F, Kovács L et al (2010) Ulcerative colitis and primary sclerosing cholangitis as part of autoimmune polyglandular syndrome type III. Inflamm Bowel Dis 16:10–11CrossRefPubMed
28.
Zurück zum Zitat Felber J, Aust D, Baas S et al (2014) Results of a S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and Metabolic Diseases (DGVS) in Conjunction with the German Coeliac Society (DZG) Regarding Coeliac Disease, Wheat Allergy and Wheat Sensitivity. Z Gastroenterol 52:711–743CrossRefPubMed Felber J, Aust D, Baas S et al (2014) Results of a S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and Metabolic Diseases (DGVS) in Conjunction with the German Coeliac Society (DZG) Regarding Coeliac Disease, Wheat Allergy and Wheat Sensitivity. Z Gastroenterol 52:711–743CrossRefPubMed
29.
Zurück zum Zitat Finnish-German-Apeced-Consortium (1997) An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17:399–403CrossRef Finnish-German-Apeced-Consortium (1997) An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17:399–403CrossRef
30.
Zurück zum Zitat Flesch BK, Matheis N, Alt T et al (2014) HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III. J Clin Endocrinol Metab 99:E177–E182CrossRefPubMed Flesch BK, Matheis N, Alt T et al (2014) HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III. J Clin Endocrinol Metab 99:E177–E182CrossRefPubMed
31.
Zurück zum Zitat Förster G, Krummenauer F, Kuhn I et al (1999) Polyglandular autoimmune syndrome type II: Epidemiology and forms of manifestation. Dtsch Med Wochenschr 124:1476–1481CrossRefPubMed Förster G, Krummenauer F, Kuhn I et al (1999) Polyglandular autoimmune syndrome type II: Epidemiology and forms of manifestation. Dtsch Med Wochenschr 124:1476–1481CrossRefPubMed
32.
Zurück zum Zitat Hansen MP, Kahaly GJ (2013) Autoimmune polyglandular syndromes. Dtsch Med Wochenschr 138:319–326 (quiz 327–318)CrossRefPubMed Hansen MP, Kahaly GJ (2013) Autoimmune polyglandular syndromes. Dtsch Med Wochenschr 138:319–326 (quiz 327–318)CrossRefPubMed
33.
Zurück zum Zitat Hansen MP, Wunderlich SA, Storz SM et al (2014) The polyglandular autoimmune syndrome-quality of life and family clustering. Dtsch Med Wochenschr 139:1876–1882CrossRefPubMed Hansen MP, Wunderlich SA, Storz SM et al (2014) The polyglandular autoimmune syndrome-quality of life and family clustering. Dtsch Med Wochenschr 139:1876–1882CrossRefPubMed
35.
Zurück zum Zitat Hellmig S, Stüber E, Fölsch U et al (2004) Complications of an Addisonian crisis. Gut Liver 53:1219CrossRef Hellmig S, Stüber E, Fölsch U et al (2004) Complications of an Addisonian crisis. Gut Liver 53:1219CrossRef
36.
Zurück zum Zitat Herrod HG (1990) Chronic mucocutaneous candidiasis in childhood and complications of non-Candida infection: A report of the Pediatric Immunodeficiency Collaborative Study Group. J Pediatr 116:377–382CrossRefPubMed Herrod HG (1990) Chronic mucocutaneous candidiasis in childhood and complications of non-Candida infection: A report of the Pediatric Immunodeficiency Collaborative Study Group. J Pediatr 116:377–382CrossRefPubMed
37.
Zurück zum Zitat Horie I, Kawasaki E, Ando T et al (2012) Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population. J Clin Endocrinol Metab 97:E1043–E1050CrossRefPubMed Horie I, Kawasaki E, Ando T et al (2012) Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population. J Clin Endocrinol Metab 97:E1043–E1050CrossRefPubMed
38.
Zurück zum Zitat Huibregtse KE, Wolfgram P, Winer KK et al (2014) Polyglandular autoimmune syndrome type I – a novel AIRE mutation in a North American patient. J Pediatr Endocrinol Metab. doi:10.1515/jpem-2013-0328 Huibregtse KE, Wolfgram P, Winer KK et al (2014) Polyglandular autoimmune syndrome type I – a novel AIRE mutation in a North American patient. J Pediatr Endocrinol Metab. doi:10.​1515/​jpem-2013-0328
39.
Zurück zum Zitat Husebye ES, Perheentupa J, Rautemaa R et al (2009) Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med 265:514–529CrossRefPubMed Husebye ES, Perheentupa J, Rautemaa R et al (2009) Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J Intern Med 265:514–529CrossRefPubMed
40.
Zurück zum Zitat Kagnoff MF (2007) Celiac disease: Pathogenesis of a model immunogenetic disease. J Clin Invest 17:41–49CrossRef Kagnoff MF (2007) Celiac disease: Pathogenesis of a model immunogenetic disease. J Clin Invest 17:41–49CrossRef
41.
Zurück zum Zitat Kakleas K, Paschali E, Kefalas N et al (2009) Factors for thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Ups J Med Sci 114:214–220CrossRefPubMedPubMedCentral Kakleas K, Paschali E, Kefalas N et al (2009) Factors for thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Ups J Med Sci 114:214–220CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Keenan BP, Yalamanchi S, Hsu S et al (2016) True, true, related? Autoimmune Polyglandular syndrome type II. Am J Med 129:38–41CrossRefPubMed Keenan BP, Yalamanchi S, Hsu S et al (2016) True, true, related? Autoimmune Polyglandular syndrome type II. Am J Med 129:38–41CrossRefPubMed
43.
Zurück zum Zitat Kluger N, Jokinen M, Krohn K et al (2013) Gastrointestinal manifestations in APECED syndrome. J Clin Gastroenterol 47:112–120CrossRefPubMed Kluger N, Jokinen M, Krohn K et al (2013) Gastrointestinal manifestations in APECED syndrome. J Clin Gastroenterol 47:112–120CrossRefPubMed
44.
Zurück zum Zitat Kyriacou A, Mclaughlin J, Syed AA (2015) Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review. Eur J Intern Med 26:563–571CrossRefPubMed Kyriacou A, Mclaughlin J, Syed AA (2015) Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review. Eur J Intern Med 26:563–571CrossRefPubMed
45.
Zurück zum Zitat Lahner E, Spoletini M, Buzzetti R et al (2010) HLA-DRB1*03 and DRB1*04 are associated with atrophic gastritis in an Italian population. Dig Liver Dis 42:854–859CrossRefPubMed Lahner E, Spoletini M, Buzzetti R et al (2010) HLA-DRB1*03 and DRB1*04 are associated with atrophic gastritis in an Italian population. Dig Liver Dis 42:854–859CrossRefPubMed
46.
Zurück zum Zitat Lankisch TO, Jaeckel E, Strassburg CP (2009) The autoimmune PolyendocrinopathyCandidiasis-Ectodermal dystrophy or autoimmune Polyglandular syndrome type 1. Semin Liver Dis 29:307–314CrossRefPubMed Lankisch TO, Jaeckel E, Strassburg CP (2009) The autoimmune PolyendocrinopathyCandidiasis-Ectodermal dystrophy or autoimmune Polyglandular syndrome type 1. Semin Liver Dis 29:307–314CrossRefPubMed
47.
Zurück zum Zitat Leffler DA, Schuppan D (2010) Update on serologic testing in celiac disease. Am J Gastroenterol 105:2520–2524CrossRefPubMed Leffler DA, Schuppan D (2010) Update on serologic testing in celiac disease. Am J Gastroenterol 105:2520–2524CrossRefPubMed
48.
Zurück zum Zitat Lewis JR, Radavelli-Bagatini S, Rejnmark L et al (2015) The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: A collaborative Meta-analysis of randomized controlled trials. J Bone Miner Res 30:165–175CrossRefPubMed Lewis JR, Radavelli-Bagatini S, Rejnmark L et al (2015) The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: A collaborative Meta-analysis of randomized controlled trials. J Bone Miner Res 30:165–175CrossRefPubMed
49.
Zurück zum Zitat Liao KP, Gunnarsson M, Källberg H et al (2009) A specific association exists between type 1 diabetes and anti-CCP positive rheumatoid arthritis. Arthritis Rheum 60:653–660CrossRefPubMedPubMedCentral Liao KP, Gunnarsson M, Källberg H et al (2009) A specific association exists between type 1 diabetes and anti-CCP positive rheumatoid arthritis. Arthritis Rheum 60:653–660CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Manns MP, Czaja AJ, Gorham JD et al (2010) Diagnosis and management of autoimmune hepatitis. Hepatology 51:2193–2213CrossRefPubMed Manns MP, Czaja AJ, Gorham JD et al (2010) Diagnosis and management of autoimmune hepatitis. Hepatology 51:2193–2213CrossRefPubMed
51.
Zurück zum Zitat Masia R, Peyton S, Lauwers GY et al (2014) Gastrointestinal biopsy findings of autoimmune enteropathy: A review of 25 cases. Am J Surg Pathol 38:1319–1329CrossRefPubMedPubMedCentral Masia R, Peyton S, Lauwers GY et al (2014) Gastrointestinal biopsy findings of autoimmune enteropathy: A review of 25 cases. Am J Surg Pathol 38:1319–1329CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Massironi S, Cavalcoli F, Rossi RE et al (2013) Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: A transversal prospective study. Eur J Endocrinol 168:755–761CrossRefPubMed Massironi S, Cavalcoli F, Rossi RE et al (2013) Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: A transversal prospective study. Eur J Endocrinol 168:755–761CrossRefPubMed
53.
Zurück zum Zitat Mazza C, Buzi F, Ortolani F et al (2011) Clinical heterogeneity and diagnostic delay of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. Clin Immunol 139:6–11CrossRefPubMed Mazza C, Buzi F, Ortolani F et al (2011) Clinical heterogeneity and diagnostic delay of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. Clin Immunol 139:6–11CrossRefPubMed
54.
Zurück zum Zitat Mccanlies E, O’leary LA, Foley TP et al (1998) Hashimoto’s thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin Endocrinol Metab 83:1548–1551PubMed Mccanlies E, O’leary LA, Foley TP et al (1998) Hashimoto’s thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin Endocrinol Metab 83:1548–1551PubMed
55.
Zurück zum Zitat Meier N, Lipp E, Solenthaler M (2007) Pancytopenia and hemolysis – diagnosis, differential diagnosis and therapy of pernicious anemia. Dtsch Med Wochenschr 132:1469–1474CrossRefPubMed Meier N, Lipp E, Solenthaler M (2007) Pancytopenia and hemolysis – diagnosis, differential diagnosis and therapy of pernicious anemia. Dtsch Med Wochenschr 132:1469–1474CrossRefPubMed
56.
Zurück zum Zitat Mizokami T, Yamauchi A, Sato Y et al (2013) Simultaneous occurrence of type 1 diabetes mellitus and Graves’ disease: A report of two cases and a review of the literature. Intern Med 52:2537–2543CrossRefPubMed Mizokami T, Yamauchi A, Sato Y et al (2013) Simultaneous occurrence of type 1 diabetes mellitus and Graves’ disease: A report of two cases and a review of the literature. Intern Med 52:2537–2543CrossRefPubMed
57.
58.
Zurück zum Zitat Obermayer-Straub P, Strassburg CP, Manns MP (2000) Autoimmune Polyglandular syndrome type 1. Clin Rev Allergy Immunol 18:167–183CrossRefPubMed Obermayer-Straub P, Strassburg CP, Manns MP (2000) Autoimmune Polyglandular syndrome type 1. Clin Rev Allergy Immunol 18:167–183CrossRefPubMed
59.
Zurück zum Zitat Ogata A, Morishima A, Hirano T et al (2011) Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab. Ann Rheum Dis 70:1164–1165CrossRefPubMed Ogata A, Morishima A, Hirano T et al (2011) Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab. Ann Rheum Dis 70:1164–1165CrossRefPubMed
60.
Zurück zum Zitat Papadopoulos KI, Hallengren B (1990) Polyglandular autoimmune syndrome type II in patients with idiopathic Addison’s disease. Acta Endocrinol 122:472–478PubMed Papadopoulos KI, Hallengren B (1990) Polyglandular autoimmune syndrome type II in patients with idiopathic Addison’s disease. Acta Endocrinol 122:472–478PubMed
61.
Zurück zum Zitat Patel T, Nystrom J, Pyrsopoulos N (2010) Autoimmune hepatitis as a part of polyglandular autoimmune syndrome type II: Case report and literature review. Dig Dis Sci 55:861–864CrossRefPubMed Patel T, Nystrom J, Pyrsopoulos N (2010) Autoimmune hepatitis as a part of polyglandular autoimmune syndrome type II: Case report and literature review. Dig Dis Sci 55:861–864CrossRefPubMed
62.
Zurück zum Zitat Perros P, Mccrimmon R, Shaw G et al (1995) Frequency of thyroid dysfunction in diabetic patients: Value of annual screening. Diabet Med 12:622–627CrossRefPubMed Perros P, Mccrimmon R, Shaw G et al (1995) Frequency of thyroid dysfunction in diabetic patients: Value of annual screening. Diabet Med 12:622–627CrossRefPubMed
63.
Zurück zum Zitat Posovszky C, Lahr G, Von Schnurbein J et al (2012) Loss of enteroendocrine cells in autoimmune-polyendocrine-candidiasis-ectodermal-dystrophy (APECED) syndrome with gastrointestinal dysfunction. J Clin Endocrinol Metab 97:E292–E300CrossRefPubMed Posovszky C, Lahr G, Von Schnurbein J et al (2012) Loss of enteroendocrine cells in autoimmune-polyendocrine-candidiasis-ectodermal-dystrophy (APECED) syndrome with gastrointestinal dysfunction. J Clin Endocrinol Metab 97:E292–E300CrossRefPubMed
65.
66.
Zurück zum Zitat Richette P, Doherty M, Pascual E et al (2016) 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis 26:29–41 Richette P, Doherty M, Pascual E et al (2016) 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis 26:29–41
67.
Zurück zum Zitat Rizvi A, Kerrick J (2001) Liver involvement and abnormal iron variables in undiagnosed Addison’s disease. Endocr Pract 7:184–188CrossRefPubMed Rizvi A, Kerrick J (2001) Liver involvement and abnormal iron variables in undiagnosed Addison’s disease. Endocr Pract 7:184–188CrossRefPubMed
68.
Zurück zum Zitat Roubille C, Richer V, Starnino T et al (2015) The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: A systematic review and meta-analysis. Ann Rheum Dis 74:480–489CrossRefPubMedPubMedCentral Roubille C, Richer V, Starnino T et al (2015) The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: A systematic review and meta-analysis. Ann Rheum Dis 74:480–489CrossRefPubMedPubMedCentral
69.
Zurück zum Zitat Sanders K, Stuart A, Williamson E et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA 303:1815–1822CrossRefPubMed Sanders K, Stuart A, Williamson E et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA 303:1815–1822CrossRefPubMed
70.
Zurück zum Zitat Scaramuzza AE, Mantegazza C, Bosetti A et al (2013) Type 1 diabetes and celiac disease: The effects of gluten free diet on metabolic control. World J Diabetes 4:130–134CrossRefPubMedPubMedCentral Scaramuzza AE, Mantegazza C, Bosetti A et al (2013) Type 1 diabetes and celiac disease: The effects of gluten free diet on metabolic control. World J Diabetes 4:130–134CrossRefPubMedPubMedCentral
71.
Zurück zum Zitat Schuppan D, Junker Y, Barisan D (2009) Celiac disease: From pathogenesis to novel therapies. Gastroenterology 137:1912–1933 Schuppan D, Junker Y, Barisan D (2009) Celiac disease: From pathogenesis to novel therapies. Gastroenterology 137:1912–1933
72.
Zurück zum Zitat Sinha R, Chapman A, Reid G et al (2015) Fulminant hepatic failure in autoimmune polyendocrine syndrome type-1. J R Coll Physicians Edinb 45:136–140CrossRefPubMed Sinha R, Chapman A, Reid G et al (2015) Fulminant hepatic failure in autoimmune polyendocrine syndrome type-1. J R Coll Physicians Edinb 45:136–140CrossRefPubMed
73.
Zurück zum Zitat Stallmach A, Schuppan D (2015) Diagnostics and treatment of celiac disease. Dtsch Med Wochenschr 140:198CrossRefPubMed Stallmach A, Schuppan D (2015) Diagnostics and treatment of celiac disease. Dtsch Med Wochenschr 140:198CrossRefPubMed
74.
Zurück zum Zitat Teufel A, Weinmann A, Kahaly G et al (2010) Concurrent autoimmune diseases in patients with autoimmune hepatitis. J Clin Gastroenterol 44:208–213CrossRefPubMed Teufel A, Weinmann A, Kahaly G et al (2010) Concurrent autoimmune diseases in patients with autoimmune hepatitis. J Clin Gastroenterol 44:208–213CrossRefPubMed
75.
Zurück zum Zitat Van Der Goes MC, Jacobs JWG, Boers M et al (2010) Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice. Ann Rheum Dis :1913–1919. doi:10.1136/ard.2009.124958 Van Der Goes MC, Jacobs JWG, Boers M et al (2010) Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice. Ann Rheum Dis :1913–1919. doi:10.​1136/​ard.​2009.​124958
76.
Zurück zum Zitat Vianello M, Tavolato B, Giometto B (2002) Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci 23:145–151CrossRefPubMed Vianello M, Tavolato B, Giometto B (2002) Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci 23:145–151CrossRefPubMed
77.
Zurück zum Zitat Watad A, Cohen AD, Comaneshter D et al (2015) Hyperthyroidism association with SLE, lessons from real-life data – A case-control study. Autoimmunity 49:17–20CrossRefPubMed Watad A, Cohen AD, Comaneshter D et al (2015) Hyperthyroidism association with SLE, lessons from real-life data – A case-control study. Autoimmunity 49:17–20CrossRefPubMed
78.
Zurück zum Zitat Wielosz E, Majdan M, Koszarny A et al (2016) Presence of organspecific antibodies in patients with systemic sclerosis. Pol Arch Med Wewn 126:862–869PubMed Wielosz E, Majdan M, Koszarny A et al (2016) Presence of organspecific antibodies in patients with systemic sclerosis. Pol Arch Med Wewn 126:862–869PubMed
79.
Zurück zum Zitat Ye W, Nyrén O (2003) Risk of cancers of the oesophagus and stomach by histology or subsite in patients hospitalised for pernicious anaemia. Gut Liver 52:938–941CrossRef Ye W, Nyrén O (2003) Risk of cancers of the oesophagus and stomach by histology or subsite in patients hospitalised for pernicious anaemia. Gut Liver 52:938–941CrossRef
Metadaten
Titel
Endokrinologie als Schnittstelle in der interdisziplinären Inneren Medizin
Veranschaulichung anhand des polyglandulären Autoimmunsyndroms
verfasst von
Prof. Dr. G. J. Kahaly
J. Zimmermann
M. P. Hansen
F. Gundling
F. Popp
M. Welcker
Publikationsdatum
23.02.2017
Verlag
Springer Medizin
Erschienen in
Die Innere Medizin / Ausgabe 4/2017
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-017-0201-8

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