We read with interest the recent article by Liao et al. who concluded that patients in the endovascular cooling (EC) group had shorter intensive care unit (ICU) hospitalization and a better neurological prognosis than those in the surface cooling (SC) group [1]. In their discussion, they noted several adverse events associated with both techniques including arrhythmia, infection, pneumonia, and bleeding [1]. We would like to speak about a very important and frequent complication linked to EC that the authors neglected to mention. Andremont et al. matched an endovascular cooling catheter cohort of 108 patients with a retrospective historical cohort of 512 patients with femoral venous catheters to compare thrombotic and infectious complications [2]. The duration of catheterization was 4.9 days in the control group vs. 4.2 days in the endovascular cooling group. After propensity score matching, there were significantly more thrombotic complications in the cooling group (12 of 75, 16%) than in the control group (0 of 75, 0%), and 4 patients presented major complications. In another study, Maze et al. investigated the risk of catheter-related thrombosis associated with the use of endovascular cooling catheters in a cohort of 80 patients initially treated with therapeutic hypothermia (TH) of which 61 completed the cooling protocol using an EC device [3]. They further evaluated the incidence of thrombosis between patients on dose-adjusted intravenous unfractionated heparin compared to those on a subcutaneous prophylactic regimen alone. Catheter-related thrombosis was observed in 9/61 (14.7%), with nine events in the prophylaxis group compared to none in the full-dose unfractionated heparin group (22.0% vs. 0.0%). Jung et al. [4] reported a case of an endovascular cooling catheter-related right atrial thrombus (RAT) in a 17-year-old boy treated with therapeutic hypothermia using an endovascular cooling catheter following ventricular fibrillation cardiac arrest. The RAT was detected 3 days after the placement of the cooling catheter and resolved after treatment with enoxaparin for 2 weeks. Thrombosis is an important and potentially life-threatening complication of cooling catheter use, and its prevention with therapeutic anticoagulation may incur significant side effects like bleeding.
Acknowledgements
None.
Anzeige
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The authors declare to have no competing interests.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.