Erschienen in:
01.02.2013 | Research Article
Evaluation of an attenuation correction method for PET/MR imaging of the head based on substitute CT images
verfasst von:
Anne Larsson, Adam Johansson, Jan Axelsson, Tufve Nyholm, Thomas Asklund, Katrine Riklund, Mikael Karlsson
Erschienen in:
Magnetic Resonance Materials in Physics, Biology and Medicine
|
Ausgabe 1/2013
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Abstract
Object
The aim of this study was to evaluate MR-based attenuation correction of PET emission data of the head, based on a previously described technique that calculates substitute CT (sCT) images from a set of MR images.
Materials and methods
Images from eight patients, examined with 18F-FLT PET/CT and MRI, were included. sCT images were calculated and co-registered to the corresponding CT images, and transferred to the PET/CT scanner for reconstruction. The new reconstructions were then compared with the originals. The effect of replacing bone with soft tissue in the sCT-images was also evaluated.
Results
The average relative difference between the sCT-corrected PET images and the CT-corrected PET images was 1.6 % for the head and 1.9 % for the brain. The average standard deviations of the relative differences within the head were relatively high, at 13.2 %, primarily because of large differences in the nasal septa region. For the brain, the average standard deviation was lower, 4.1 %. The global average difference in the head when replacing bone with soft tissue was 11 %.
Conclusion
The method presented here has a high rate of accuracy, but high-precision quantitative imaging of the nasal septa region is not possible at the moment.