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24.11.2022 | Neuro

Evaluation of deep gray matter for early brain development using quantitative susceptibility mapping

verfasst von: Sayo Otani, Yasutaka Fushimi, Kogoro Iwanaga, Seiichi Tomotaki, Taiki Shimotsuma, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Krishna Pandu Wicaksono, Junko Takita, Masahiko Kawai, Yuji Nakamoto

Erschienen in: European Radiology | Ausgabe 6/2023

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Abstract

Objectives

To evaluate susceptibility values associated with iron accumulation in the deep gray matter during postnatal development and to compare magnetic susceptibility between patients with normal and delayed development.

Methods

Patients with postmenstrual age (PMA) ≤ 1000 days underwent MR scans between August 2015 and April 2020 at our hospital. Quantitative susceptibility mapping (QSM) was performed, and magnetic susceptibility was measured using three-dimensional volumes of interest (VOIs) for the caudate nucleus (CN), globus pallidus (GP), putamen (PT), and ventrolateral thalamic nucleus (VL). Cross-sectional analysis was performed for 99 patients with normal development and 39 patients with delayed development. Longitudinal analysis was also performed to interpret changes over time in 13 patients with normal development. Correlations between magnetic susceptibility in VOIs and PMA or chronological age (CA) were assessed.

Results

Susceptibility values for CN, GP, PT, and VL showed positive moderate correlations with both PMA (ρ = 0.45, 0.69, 0.62, and 0.33, respectively) and CA (ρ = 0.53, 0.69, 0.66, and 0.39, respectively). The slope of the correlation between susceptibility values and age was highest in the GP among the four gray matter areas. Susceptibility values for the CN, GP, PT, and VL were higher with normal development than with delayed development at early postnatal age, although a significant difference was only observed for the CN. Susceptibility values also increased with age in the longitudinal analysis.

Conclusions

Magnetic susceptibility values in deep gray matter increased with age ≤ 1000 days. The normal development group showed higher susceptibility values than the delayed development group at early postnatal age (PMA ≤ 285 days).

Key Points

• Magnetic susceptibilities in deep gray matter nuclei increased with age (postmenstrual age ≤ 1000 days) in a large number of pediatric patients.

• The normal development group showed higher susceptibility values than the delayed development group in the basal ganglia and ventrolateral thalamic nucleus at early postnatal age (PMA ≤ 285 days).

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Titel: Evaluation of deep gray matter for early brain development using quantitative susceptibility mapping
verfasst von: Sayo Otani
Yasutaka Fushimi
Kogoro Iwanaga
Seiichi Tomotaki
Taiki Shimotsuma
Satoshi Nakajima
Akihiko Sakata
Sachi Okuchi
Takuya Hinoda
Krishna Pandu Wicaksono
Junko Takita
Masahiko Kawai
Yuji Nakamoto
Publikationsdatum: 24.11.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2023
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-022-09267-4

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Evaluation of deep gray matter for early brain development using quantitative susceptibility mapping