Background
Adolescence is a period of rapid development and change, as well as a time of frequent mental health problems, especially anxiety and depression, the two most common psychological problems reported during this developmental period [
1,
2]. Co-occurrence of the two is referred to as comorbid anxiety and depression (CAD), which can increase treatment difficulty, length of illness duration, worsen prognosis and recovery, and increase rates of disability and suicide compared to the existence of a single disorder [
3‐
5]. According to recent meta-analysis studies by Zhang et al. [
6] and Yu et al. [
7], the prevalence of anxiety ranges from 26.3 to 27%, while the prevalence of depression ranges from 24 to 28%. Meanwhile, among individuals experiencing anxiety or depression, the prevalence of current or lifetime CAD is reported to range from 10 to 75% [
8,
9], indicating that a substantial proportion of adolescents experience both anxiety and depression. Given the adverse consequences and high prevalence of CAD, it is essential to carry out research with the potential to enhance our knowledge of it during this developmental period, thereby promoting public health initiatives in mental health promotion and early prevention.
Both the latent variable model and the network model are used to study CAD [
10], offering different perspectives on symptoms and their relationships. The former considers symptoms as mere reflective indicators of underlying diseases and disregards any potential interaction among the symptoms themselves [
10,
11]. However, empirical evidence suggests that this theoretical stance does not adequately align with reality [
12]. For instance, persistent low mood may result in insomnia, subsequently leading to difficulties in maintaining focus during the day and increased irritability in social activities. Psychopathology network theory provides a more nuanced conceptualization of this issue by shifting the perspective to view symptoms as a causal system. According to this theory, symptoms not only indicate but also contribute to the disorder itself. It is the symptoms, along with their interactions, that effectively constitute the disorder [
13,
14]. Thus, comorbidity naturally arises from the interconnected of symptom networks [
10]. Moving beyond the mere calculation of total symptom scores to evaluate disease severity, network theory offers a deeper understanding of the importance of individual symptoms in the progression of the disorder.
Indeed, several studies have utilized dynamic symptom interaction networks to explore mental disorders, where symptoms are represented as “nodes” and inter-symptom correlations as “edges” [
13]. Some studies in children and adolescents have identified core symptoms and global strength as important characteristics of CAD through network analysis. Core symptoms refer to those that are strongly connected to other symptoms within the network [
15]; global strength of a network measures the overall connectivity, with stronger connectivity indicating greater vulnerability and susceptibility to mental disorders [
16]. In previous research, McElroy et al. [
14] found that “anxious/fearful” and “unhappy/sad” were the core symptoms during the developmental stage of 5–14 years old and observed an increasing trend in the global strength of the network. However, bridge symptoms, which connect symptoms of different disorders [
17], were not examined in their study. In another study on CAD conducted by Cai et al. [
18] focusing on late adolescence, “sad mood” and “worry too much” were also identified as core symptoms. Additionally, “irritability” and “guilty” were core symptoms as well. The study further identified “guilty,” “sad mood,” and “suicide ideation” as bridge symptoms [
18]. However, there is a research gap in fully exploring the comprehensive set of core and bridge symptoms of CAD in the specific developmental stage of adolescence.
Additionally, previous studies have extensively documented the dynamic developmental patterns of anxiety and depression in adolescence, but limited research has specifically focused on understanding the changes that CAD may undergo during this developmental period. For example, McLaughlin and King [
19] found that anxiety severity, as measured by the average total score, decreased across adolescence, while depression severity remained stable. Using the tripartite model of CAD, Conway et al. [
20] documented that negative affect and anxious arousal dimensions showed a decline over time, whereas the anhedonia dimension did not. McElroy et al. [
14] conducted a network analysis study on individuals from ages 5 to 14 and found that symptoms within the CAD network were highly interconnected, and the node strength (an indicator of core symptoms) exhibited developmental variations in this age period.
Therefore, it remains crucial to investigate whether the distinct symptoms of CAD also undergo changes throughout the specific period of adolescence, utilizing network analysis. Network analysis can provide valuable insights by investigating bridge symptoms and core symptoms, as well as evaluating changes in global strengt
h over time. By intervening on bridge and core symptoms to mitigate their mutual influence and prioritizing the allocation of healthcare resources to groups with higher global symptom strength, we can potentially enhance the effectiveness of public health initiatives [
17,
21,
22].
Building upon the evolving understanding of the comorbidity of anxiety and depression during adolescence, we hypothesize that the network structure of CAD also differs across developmental stages. Based on previous research among Chinese adolescents [
23,
24], the transition from early to late adolescence is marked by changes in school contexts, with significant shifts in academic routines and expectations, school environments, and social groups and relationships. Consistent with this past research, we categorized age into distinct developmental stages: early adolescence (10–12 years), middle adolescence (13–15 years), and late adolescence (16–18 years). The goal of our study is to use network analysis to capture characteristics of CAD and compare symptom-level susceptibility to comorbidity across stages of adolescence. Specifically, we will (1) identify bridge symptoms and core symptoms within the CAD network and (2) compare the network structures across the three stages of adolescence. By accomplishing these objectives, we aim to gain insights into the distinctive features of CAD and examine how its network evolves during different stages of adolescence.
Discussion
In the current study, we conducted a network analysis to explore the network structures of CAD and susceptibility differences to CAD in early, middle, and late adolescence. We identified several core symptoms of CAD, as well as bridge symptoms between anxiety and depression in the CAD network. First, “loss of control” emerged as the core CAD symptom throughout all three developmental stages. “Excessive worry” and “anhedonia” were identified as core symptoms in early adolescence, and “restlessness” was a core symptom in late adolescence. Second, when concentrating on the overlap between anxiety and depression, “anhedonia,” “sad mood,” and “fatigue” were the bridge symptoms across all three developmental stages, suggesting that these symptoms connect and transmit comorbidity between anxiety and depression. In examining the network structures across three developmental stages, the data revealed that the middle adolescence stage exhibited the highest global strength, with a significant difference observed when comparing the middle to the early adolescence stages. Although there was no statistically significant difference between the middle and late adolescence stages, the middle stage’s global strength remained the highest. This suggests that the middle stage of adolescence may be a period of increased vulnerability and susceptibility to mental disorders, including CAD.
CAD core symptoms
“Loss of control” was identified as highly central in the CAD network throughout the three adolescent stages. This finding aligns with previous studies conducted in different populations. For instance, in studies involving patients diagnosed with both anxiety and depression in Germany (42.24 ± 14.38 years old,
n = 5614) [
39], and patients with epilepsy in China (31.5 ± 2.3 years old,
n = 313) [
40], “loss of control” was also identified as a core symptom. Despite the differences in demographics, associated life stressors, and diagnostic status of participants, the consistency in identifying “loss of control” as a core symptom suggests its significance in anxiety-depression comorbidity.
The presence of “loss of control” as a core symptom across diverse populations indicates its potential as a hallmark symptom in the development of CAD. Psychoeducation and cognitive-behavioral therapy (CBT) have shown effectiveness in improving emotion regulation skills, which can help individuals better cope with feelings of losing control. For example, meta-cognitive therapy can be used to modify adolescents’ beliefs about worry, shifting the focus from the concern itself to their thoughts about the concern [
41]. By targeting “loss of control” as a core symptom and incorporating interventions such as psychoeducation and CBT, it may be possible to enhance emotion regulation and reduce the severity of anxiety and depression comorbidity. This highlights the importance of implementing targeted interventions that address specific core symptoms to improve overall mental well-being in adolescents.
Additionally, in early adolescence, “excessive worry” and “anhedonia” were two core symptoms specific to this stage. Early adolescence typically encompasses the age range of 10–12 years. During this period, self-awareness is gradually enhanced, and adolescents actively explore the external world while facing new tasks and challenges independently [
42]. It is not uncommon for them to encounter failure and experience heightened frustration as they navigate these new experiences. Prolonged experiences of failure can lead to a diminished interest in various activities, which is captured by the symptom of “anhedonia” [
43]. Given the unique challenges faced by early adolescents, it is crucial to implement preventative measures and targeted interventions for these two core symptoms. One approach could involve equipping early adolescents with coping skills and providing them with resources to effectively navigate failure and manage excessive worry. By empowering early adolescents with appropriate strategies, they can develop resilience and adaptive responses to challenging situations, potentially mitigating the risk of anxiety and depression comorbidity.
On the other hand, “restlessness” was another core symptom in late adolescence, which also requires targeted preventative measures and interventions. Interestingly, this symptom has also been identified as a core symptom of CAD in Chinese adults following the peak of the pandemic [
44]. Stressful events and circumstances have been found to play a significant role in the manifestation of restlessness [
45].
In late adolescence, individuals aged 16–18 in China face a particularly stressful event: a college entrance examination, which is an important event for students and their families. During this final stage of adolescence, individuals are not only burdened by the weight of academic expectations and uncertainties about their future educational and career paths, but also face pressure from teachers and parents [
46,
47]. These demanding and stressful circumstances can contribute to a state of restlessness among adolescents.
To relieve or alleviate this core symptom, it is essential to provide effective stress management techniques and coping strategies that can help adolescents manage their stress levels. Approaches such as self-compassion, mindfulness, regular exercise, and relaxation techniques like listening to music can be valuable tools in reducing restlessness and promoting emotional well-being [
48‐
51]. Furthermore, it is important for parents and educators to support late adolescents during this critical period of transition into adulthood by providing resources, support systems, and fostering open communication. By creating a nurturing and understanding environment, adolescents can better cope with the stressors they face and build resilience as they navigate this challenging phase of their lives.
CAD bridge symptoms
We found that “anhedonia,” “sad mood,” and “fatigue” may bridge the associations between anxiety and depression and contribute to the development and maintenance of CAD. Similar bridge symptoms have been reported in studies involving different populations, such as migrant Filipino domestic workers in Macao and Chinese nursing students and adolescents [
18,
52‐
54]. It has been proposed that anxiety may transform into depression through the manifestation of “anhedonia” [
55]. Anhedonia is associated with a decrease in desire, interest, and reinforcement learning [
56,
57]. Individuals experiencing prolonged stress and anxiety may progress to a depleted phase characterized by symptoms of fatigue, sad mood, and loss of motivation [
58], thereby triggering a depressed state. Additionally, the tripartite model suggests that negative affectivity, such as “sad mood,” is common to both anxiety and depression [
59]. The sustained arousal caused by worry may lead to emotional and physical exhaustion, eventually resulting in low mood and the development of other depressive symptoms [
32]. In this case, the symptom of “sad mood” may reflect a progression from anxiety to depression. These findings contribute to our understanding of CAD in adolescence and highlight potential avenues for intervention and prevention strategies aimed at targeting specific core symptoms and bridge symptoms associated with CAD.
Furthermore, the bridge symptom of “fatigue” may be linked to the somatization of psychological distress, which is particularly prevalent in Asian populations, including China [
60]. Cultural norms that prioritize the suppression of personal emotions and the persistent stigma surrounding mental health problems contribute to this phenomenon [
61]. Adolescents, in particular, are more likely to somaticize their mental health issues rather than directly addressing them [
39]. This tendency is further corroborated by qualitative research that examines the stress and coping strategies of adolescents in a Chinese population, where avoidance of direct confrontation with mental health issues is common, and somatization can be a culturally embedded response to distress [
62‐
64].
Besides, Chinese adolescents face excessive burdens that may contribute to their fatigue [
40]. They are often required to dedicate extensive time to academic pursuits, leaving little time for entertainment, social activities, and even adequate sleep. The cumulative effect of these demands on their physical and mental well-being can manifest as fatigue. Overall, the cultural context and the high levels of stress and responsibilities experienced by Chinese adolescents contribute to the prominence of “fatigue” as a bridge symptom in CAD. Recognizing these cultural and contextual factors is crucial for understanding the unique manifestations of CAD in this population and for developing targeted interventions and support systems.
Global strength differences in three developmental stages
The global strength of the network during middle adolescence was found to be higher compared to early and late adolescence, with a significant difference observed between early and middle adolescence. This finding aligns with a previous study by Cai et al. [
18], which also reported significant differences in network global strength between junior and senior secondary school grades. Another study by McElroy et al. [
65] observed a higher connectivity in anxiety-depression comorbidity symptom networks at age 14 compared to ages 5 and 6. Despite variations in age and region, these studies collectively suggested that symptoms evolve and may reinforce each other during development, with middle adolescence emerging as a critical period for rapid comorbidity development. The heightened network connectivity observed in this stage suggests that middle adolescence may be a particularly vulnerable time for the onset of mental disorders.
Potential implications
These findings have important potential clinical implications. First, these results highlight the identified core and bridge symptoms as crucial in the development and maintenance of CAD, implying shared mechanisms through which the symptomatology is associated with anxiety and depression. Paying attention to these symptoms is vital for developing interventions that can broadly reduce the risk for CAD in adolescents. Furthermore, our study highlights the severity of CAD in adolescents and demonstrates a progressive increase in susceptibility to the development and persistence of CAD. Specifically, the transition from early to middle adolescence appears to be a critical period for the emergence of CAD, suggesting this specific age range as a target for intervention.
Limitations and future research
There are several limitations that should be acknowledged. Firstly, although network theory implies a causal account of the evolution of psychiatric syndromes [
36], the cross-sectional nature of our data prevents us from revealing causal dynamics, especially in relation to the direction of relationships between anxiety and depression symptoms [
5,
66]. As mentioned before, future longitudinal studies are needed to explore the activation of symptoms over time and provide insights into the causal relationships between symptoms [
67].
Secondly, our study only included DSM-5 symptoms of anxiety and depression, while non-DSM-5 symptoms may also play a significant role in symptom networks [
68]. Hence, including a more comprehensive set of symptoms and scales in future studies would provide a more nuanced understanding of the networks. Besides, it is important to acknowledge that symptoms from other disorders, such as post-traumatic stress disorder and eating disorders [
69,
70], may co-occur with anxiety and depression. Future research should consider incorporating these common adolescent mental health problems and their symptoms into network analyses to identify pivotal symptoms for prevention and intervention efforts.
Furthermore, the sample used in this study consisted of adolescents from a school setting, which may limit the generalizability of the findings to the broader community or clinical populations. Variations in network connectivity across different samples or populations have been observed in prior research. Therefore, caution should be exercised when extending the results to clinical settings, and it would be valuable to include clinical samples in future investigations to determine the consistency or discrepancies in the conclusions.
Lastly, considering cultural differences, it is important to note that the manifestation of emotions as somatic symptoms may more normally present in collectivist societies [
71]. While our study focused on a specific cultural context, further research is needed to verify the results in non-collectivist countries and explore the influence of cultural factors on symptom networks.
Conclusion
In summary, the current study characterized the comorbidity of anxiety and depression network within a large Chinese adolescent sample by employing network analysis. Through the examination of network structures, we identified core symptoms (e.g., “loss of control,” “excessive worry,” “anhedonia,” and “restlessness”) and bridge symptoms (e.g., “anhedonia,” “sad mood,” and “fatigue”) that were consistent across all three stages of adolescence. We also identified middle adolescence as the critical period for the rapid development of CAD.
Overall, these findings provide valuable insights into the understanding of anxiety-depression comorbidity in adolescents and emphasize the need for targeted interventions and preventive measures during specific stages of adolescence. Future work is needed to incorporate these core and bridge symptoms into the design and development of early detection and intervention strategies to address the unique challenges faced by adolescents in managing anxiety and depression.
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