Focus on fluid therapy and nutritional support

Zurück zum Zitat Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304–377. https://doi.org/10.1007/s00134-017-4683-6 CrossRefPubMed Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304–377. https://​doi.​org/​10.​1007/​s00134-017-4683-6 CrossRefPubMed

Zurück zum Zitat Machado FR, Levy MM, Rhodes A (2017) Fixed minimum volume resuscitation: pro. Intensive Care Med 43(11):1678–1680. https://doi.org/10.1007/s00134-016-4590-2 CrossRefPubMed Machado FR, Levy MM, Rhodes A (2017) Fixed minimum volume resuscitation: pro. Intensive Care Med 43(11):1678–1680. https://​doi.​org/​10.​1007/​s00134-016-4590-2 CrossRefPubMed

Zurück zum Zitat Perner A, Singer M (2017) Fixed minimum fluid volume for resuscitation: con. Intensive Care Med 43(11):1681–1682. https://doi.org/10.1007/s00134-016-4581-3 CrossRefPubMed Perner A, Singer M (2017) Fixed minimum fluid volume for resuscitation: con. Intensive Care Med 43(11):1681–1682. https://​doi.​org/​10.​1007/​s00134-016-4581-3 CrossRefPubMed

Zurück zum Zitat Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM, FEAST Trial Group (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364(26):2483–2495. https://doi.org/10.1056/NEJMoa1101549 CrossRefPubMed Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM, FEAST Trial Group (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364(26):2483–2495. https://​doi.​org/​10.​1056/​NEJMoa1101549 CrossRefPubMed

Zurück zum Zitat Reinhart K, Perner A, Sprung CL, Jaeschke R, Schortgen F, Johan Groeneveld AB, Beale R, Hartog CS, European Society of Intensive Care Medicine (2012) Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med 38(3):368–383. https://doi.org/10.1007/s00134-012-2472-9 CrossRefPubMed Reinhart K, Perner A, Sprung CL, Jaeschke R, Schortgen F, Johan Groeneveld AB, Beale R, Hartog CS, European Society of Intensive Care Medicine (2012) Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med 38(3):368–383. https://​doi.​org/​10.​1007/​s00134-012-2472-9 CrossRefPubMed

Zurück zum Zitat Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA, CHEST Investigators, Australian and New Zealand Intensive Care Society Clinical Trials Group (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 367(20):1901–1911. https://doi.org/10.1056/NEJMoa1209759 CrossRefPubMed Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA, CHEST Investigators, Australian and New Zealand Intensive Care Society Clinical Trials Group (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 367(20):1901–1911. https://​doi.​org/​10.​1056/​NEJMoa1209759 CrossRefPubMed

Zurück zum Zitat Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, Madsen KR, Moller MH, Elkjaer JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Soe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjaeldgaard AL, Fabritius ML, Mondrup F, Pott FC, Moller TP, Winkel P, Wetterslev J, 6S Trial Group, Scandinavian Critical Care Trials Group (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367(2):124–134. https://doi.org/10.1056/NEJMoa1204242 CrossRefPubMed Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, Madsen KR, Moller MH, Elkjaer JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Soe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjaeldgaard AL, Fabritius ML, Mondrup F, Pott FC, Moller TP, Winkel P, Wetterslev J, 6S Trial Group, Scandinavian Critical Care Trials Group (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367(2):124–134. https://​doi.​org/​10.​1056/​NEJMoa1204242 CrossRefPubMed

Zurück zum Zitat European Medicines Agency (2018) Hydroxyethyl starch solutions for infusion. http://www.emaeuropaeu/ema/indexjsp?curl=pages/medicines/human/referrals/Hydroxyethyl_starch-containing_solutions/human_referral_prac_000012jsp&mid = WC0b01ac05805c516f. Accessed 24 Sept 2018 European Medicines Agency (2018) Hydroxyethyl starch solutions for infusion. http://​www.​emaeuropaeu/​ema/​indexjsp?​curl=​pages/​medicines/​human/​referrals/​Hydroxyethyl_​starch-containing_​solutions/​human_​referral_​prac_​000012jsp&​mid =​ WC0b01ac05805c51​6f. Accessed 24 Sept 2018

Zurück zum Zitat Frank G (2018) HES: time to change my mind? Intensive Care Med 44(9):1577–1578. https://doi.org/10.1007/s00134-018-5124-x CrossRefPubMed Frank G (2018) HES: time to change my mind? Intensive Care Med 44(9):1577–1578. https://​doi.​org/​10.​1007/​s00134-018-5124-x CrossRefPubMed

Zurück zum Zitat Wiedermann CJ, Bellomo R, Perner A (2017) Is the literature inconclusive about the harm from HES? No. Intensive Care Med 43(10):1523–1525. https://doi.org/10.1007/s00134-016-4275-x CrossRefPubMed Wiedermann CJ, Bellomo R, Perner A (2017) Is the literature inconclusive about the harm from HES? No. Intensive Care Med 43(10):1523–1525. https://​doi.​org/​10.​1007/​s00134-016-4275-x CrossRefPubMed

Zurück zum Zitat Ertmer C, Annane D, Van Der Linden P (2017) Is the literature inconclusive about the harm from HES? Yes. Intensive Care Med 43(10):1520–1522. https://doi.org/10.1007/s00134-016-4278-7 CrossRefPubMed Ertmer C, Annane D, Van Der Linden P (2017) Is the literature inconclusive about the harm from HES? Yes. Intensive Care Med 43(10):1520–1522. https://​doi.​org/​10.​1007/​s00134-016-4278-7 CrossRefPubMed

Zurück zum Zitat Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declere AD, Preiser JC, Outin H, Troche G, Charpentier C, Trouillet JL, Kimmoun A, Forceville X, Darmon M, Lesur O, Reignier J, Abroug F, Berger P, Clec’h C, Cousson J, Thibault L, Chevret S, CRISTAL Investigators (2013) Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 310(17):1809–1817. https://doi.org/10.1001/jama.2013.280502 CrossRefPubMed Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declere AD, Preiser JC, Outin H, Troche G, Charpentier C, Trouillet JL, Kimmoun A, Forceville X, Darmon M, Lesur O, Reignier J, Abroug F, Berger P, Clec’h C, Cousson J, Thibault L, Chevret S, CRISTAL Investigators (2013) Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 310(17):1809–1817. https://​doi.​org/​10.​1001/​jama.​2013.​280502 CrossRefPubMed

Zurück zum Zitat Perner A, Haase N, Wetterslev J (2014) Mortality in patients with hypovolemic shock treated with colloids or crystalloids. JAMA 311(10):1067. https://doi.org/10.1001/jama.2014.830 CrossRefPubMed Perner A, Haase N, Wetterslev J (2014) Mortality in patients with hypovolemic shock treated with colloids or crystalloids. JAMA 311(10):1067. https://​doi.​org/​10.​1001/​jama.​2014.​830 CrossRefPubMed

Zurück zum Zitat Schetz M, Shaw AD, Vincent JL (2017) Is the literature inconclusive about the harm of HES? We are not sure. Intensive Care Med 43(10):1526–1528. https://doi.org/10.1007/s00134-016-4329-0 CrossRefPubMed Schetz M, Shaw AD, Vincent JL (2017) Is the literature inconclusive about the harm of HES? We are not sure. Intensive Care Med 43(10):1526–1528. https://​doi.​org/​10.​1007/​s00134-016-4329-0 CrossRefPubMed

Zurück zum Zitat Doshi P (2018) EMA recommendation on hydroxyethyl starch solutions obscured controversy. BMJ 360:k1287. https://doi.org/10.1136/bmj.k1287 CrossRefPubMed Doshi P (2018) EMA recommendation on hydroxyethyl starch solutions obscured controversy. BMJ 360:k1287. https://​doi.​org/​10.​1136/​bmj.​k1287 CrossRefPubMed

Zurück zum Zitat Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo Gonzalez JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM, Working Group on Gastrointestinal Function (2017) Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med 43(3):380–398. https://doi.org/10.1007/s00134-016-4665-0 CrossRefPubMedPubMedCentral Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo Gonzalez JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM, Working Group on Gastrointestinal Function (2017) Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med 43(3):380–398. https://​doi.​org/​10.​1007/​s00134-016-4665-0 CrossRefPubMedPubMedCentral

Zurück zum Zitat Arabi YM, Casaer MP, Chapman M, Heyland DK, Ichai C, Marik PE, Martindale RG, McClave SA, Preiser JC, Reignier J, Rice TW, Van den Berghe G, van Zanten AR, Weijs PJ (2017) The intensive care medicine research agenda in nutrition and metabolism. Intensive Care Med. https://doi.org/10.1007/s00134-017-4711-6 CrossRefPubMedPubMedCentral Arabi YM, Casaer MP, Chapman M, Heyland DK, Ichai C, Marik PE, Martindale RG, McClave SA, Preiser JC, Reignier J, Rice TW, Van den Berghe G, van Zanten AR, Weijs PJ (2017) The intensive care medicine research agenda in nutrition and metabolism. Intensive Care Med. https://​doi.​org/​10.​1007/​s00134-017-4711-6 CrossRefPubMedPubMedCentral

Zurück zum Zitat Marker S, Krag M, Moller MH (2017) What’s new with stress ulcer prophylaxis in the ICU? Intensive Care Med 43(8):1132–1134. https://doi.org/10.1007/s00134-017-4733-0 CrossRefPubMed Marker S, Krag M, Moller MH (2017) What’s new with stress ulcer prophylaxis in the ICU? Intensive Care Med 43(8):1132–1134. https://​doi.​org/​10.​1007/​s00134-017-4733-0 CrossRefPubMed

Zurück zum Zitat Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjaer JM, Palmqvist DF, Backlund M, Laake JH, Badstolokken PM, Gronlund J, Breum O, Walli A, Winding R, Iversen S, Jarnvig IL, White JO, Brand B, Madsen MB, Quist L, Thornberg KJ, Moller A, Wiis J, Granholm A, Anthon CT, Meyhoff TS, Hjortrup PB, Aagaard SR, Andreasen JB, Sorensen CA, Haure P, Hauge J, Hollinger A, Scheuzger J, Tuchscherer D, Vuilliomenet T, Takala J, Jakob SM, Vang ML, Paelestik KB, Andersen KLD, van der Horst ICC, Dieperink W, Fjolner J, Kjer CKW, Solling C, Solling CG, Karttunen J, Morgan MPG, Sjobo B, Engstrom J, Agerholm-Larsen B, Moller MH, group S-It (2018) Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. https://doi.org/10.1056/NEJMoa1714919 Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjaer JM, Palmqvist DF, Backlund M, Laake JH, Badstolokken PM, Gronlund J, Breum O, Walli A, Winding R, Iversen S, Jarnvig IL, White JO, Brand B, Madsen MB, Quist L, Thornberg KJ, Moller A, Wiis J, Granholm A, Anthon CT, Meyhoff TS, Hjortrup PB, Aagaard SR, Andreasen JB, Sorensen CA, Haure P, Hauge J, Hollinger A, Scheuzger J, Tuchscherer D, Vuilliomenet T, Takala J, Jakob SM, Vang ML, Paelestik KB, Andersen KLD, van der Horst ICC, Dieperink W, Fjolner J, Kjer CKW, Solling C, Solling CG, Karttunen J, Morgan MPG, Sjobo B, Engstrom J, Agerholm-Larsen B, Moller MH, group S-It (2018) Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. https://​doi.​org/​10.​1056/​NEJMoa1714919

Zurück zum Zitat Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Pelosi P, Keus F, Guttormsen AB, Schefold JC, Moller MH, SUP-ICU Investigators (2016) Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials 17(1):205. https://doi.org/10.1186/s13063-016-1331-3 CrossRefPubMedPubMedCentral Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Pelosi P, Keus F, Guttormsen AB, Schefold JC, Moller MH, SUP-ICU Investigators (2016) Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials 17(1):205. https://​doi.​org/​10.​1186/​s13063-016-1331-3 CrossRefPubMedPubMedCentral

Zurück zum Zitat Alhazzani W, Guyatt G, Alshahrani M, Deane AM, Marshall JC, Hall R, Muscedere J, English SW, Lauzier F, Thabane L, Arabi YM, Karachi T, Rochwerg B, Finfer S, Daneman N, Alshamsi F, Zytaruk N, Heel-Ansdell D, Cook D, Canadian Critical Care Trials Group (2017) Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis. Crit Care Med 45(7):1121–1129. https://doi.org/10.1097/CCM.0000000000002461 CrossRefPubMed Alhazzani W, Guyatt G, Alshahrani M, Deane AM, Marshall JC, Hall R, Muscedere J, English SW, Lauzier F, Thabane L, Arabi YM, Karachi T, Rochwerg B, Finfer S, Daneman N, Alshamsi F, Zytaruk N, Heel-Ansdell D, Cook D, Canadian Critical Care Trials Group (2017) Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis. Crit Care Med 45(7):1121–1129. https://​doi.​org/​10.​1097/​CCM.​0000000000002461​ CrossRefPubMed