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Current Allergy and Asthma Reports

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01.02.2014 | OTITIS (DP SKONER, SECTION EDITOR)

Genetic Contributors to Otitis Media: Agnostic Discovery Approaches

verfasst von: E. Kaitlynn Allen, Ani Manichaikul, Michèle M. Sale

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 2/2014

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Abstract

Otitis media (OM) is the most common disease in children in the United States, with about $5 billion spent each year in direct and indirect costs. OM is the number one reason for pediatric antibiotic usage and surgery, although treatment options are limited. Numerous studies have established the high heritability of OM and a genetic contribution to OM pathogenesis. Candidate gene studies have highlighted the roles of inflammation, mucin secretion, and pathogen recognition, but this approach is unable to identify novel pathways to target for treatment or screening purposes. Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis.

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Titel: Genetic Contributors to Otitis Media: Agnostic Discovery Approaches
verfasst von: E. Kaitlynn Allen
Ani Manichaikul
Michèle M. Sale
Publikationsdatum: 01.02.2014
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 2/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-013-0411-7

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