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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 2/2014

01.02.2014 | AUTOIMMUNITY (TK TARRANT, SECTION EDITOR)

Targeting the Molecular and Cellular Interactions of the Bone Marrow Niche in Immunologic Disease

verfasst von: Jaime M. Brozowski, Matthew J. Billard, Teresa K. Tarrant

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 2/2014

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Abstract

Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL12-abundant reticular (CAR) cells are niche components in close association with HSCs and have been more clearly defined in immune cell function and homeostasis. Importantly, cellular inhabitants of the BM niche signal through G protein-coupled surface receptors (GPCRs) for various appropriate immune functions. In this article, recent literature on BM niche inhabitants (HSCs, osteoblasts, MSCs, CAR cells) and their GPCR mechanistic interactions are reviewed for better understanding of the BM cells involved in immune development, immunologic disease, and current immune reconstitution therapies.
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Metadaten
Titel
Targeting the Molecular and Cellular Interactions of the Bone Marrow Niche in Immunologic Disease
verfasst von
Jaime M. Brozowski
Matthew J. Billard
Teresa K. Tarrant
Publikationsdatum
01.02.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 2/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-013-0402-8

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