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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 2/2014

01.02.2014 | RHINOSINUSITIS (J MULLOL, SECTION EDITOR)

MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis

verfasst von: Xin-Hao Zhang, Ya-Na Zhang, Zheng Liu

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 2/2014

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Abstract

Inflammatory upper airway diseases, particularly chronic rhinosinusitis (CRS) and allergic rhinitis (AR), have a high worldwide prevalence. CRS and AR involve sustained and exaggerated inflammation that is associated with marked changes in gene and protein expression under tight regulation. A novel group of gene expression regulators is a class of short single-stranded RNA molecules termed microRNAs (miRNAs). miRNAs can cause gene silencing through degradation of target mRNAs or inhibition of translation. Dysregulated expression of miRNAs has been shown in various human diseases, such as cancer, inflammatory skin and bowel diseases, rheumatoid arthritis, and asthma. Although studies of miRNAs in inflammatory upper airway diseases are relatively new and few, emerging evidence implicates an involvement of miRNAs in shaping the inflammation pattern in upper airways. The purpose of this review is to provide an overview on our current understanding of miRNA expression and function in CRS and AR, and to underscore the potential for clinical usage of miRNAs in CRS and AR.
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Metadaten
Titel
MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis
verfasst von
Xin-Hao Zhang
Ya-Na Zhang
Zheng Liu
Publikationsdatum
01.02.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 2/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-013-0415-3

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