Erschienen in:
17.03.2016 | Population Data
Genetic distribution of 15 autosomal STR markers in the Punjabi population of Pakistan
verfasst von:
Muhammad Adnan Shan, Manzoor Hussain, Muhammad Shafique, Muhammad Shahzad, Rukhsana Perveen, Muhammad Idrees
Erschienen in:
International Journal of Legal Medicine
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Ausgabe 6/2016
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Abstract
Genetic diversity of 15 autosomal short tandem repeat (STR) loci was evaluated in 713 unrelated individual samples of a Punjabi population of Pakistan. These loci were scrutinized to establish allelic frequencies and statistical parameters of forensic and paternity interests. A total of 165 alleles were observed with the corresponding allele frequencies ranging from 0.001 to 0.446. D2S1338 was found as the most informative locus while TPOX (0.611) was the least discriminating locus. The combined power of discrimination (CPD), the combined probability of exclusion (CPE), and cumulative probability of matching (CPM) were found equaled to 0.999999999999999998606227424808, 0.999995777557989, and 1.37543 × 10–18, respectively. All the loci followed the Hardy–Weinberg equilibrium after the Bonferroni correction (p < 0.0033) except one locus D3S1358. The study revealed that these STR loci are highly polymorphic, suitable for forensic and parentage analyses. In comparison to different populations (Asians and non-Asians), significant differences were recorded for these loci.