Erschienen in:
Open Access
01.09.2012 | Meeting abstract
Genetic polymorphisms leading to altered T-cell and dendritic cell function cooperate to produce expansion of proinflammatory T-cell subsets in NZB c1 congenic mice
verfasst von:
N Talaei, C Landolt-Marticorena, B Noamani, E Pau, N-H Chang, JE Wither
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
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Excerpt
We have previously shown that B6 mice with an introgressed homozygous NZB chromosome 1 (c1) interval (70 to 100 cM) develop high titers of antinuclear antibodies and severe glomerulonephritis. Using subcongenic mice with shorter c1 intervals, we found that expansion of TH1, TH17, and TFH cells was closely associated with the severity of glomerulonephritis. The same expansions were observed using ovalbumin (OVA) as an exogenous antigen, indicating that this was an intrinsic aspect of their immune system. Here we have investigated the role of T cells and dendritic cells (DC) in this expansion. …