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01.09.2012 | Original Paper

Grey matter abnormalities in social anxiety disorder: a pilot study

verfasst von: Supriya Syal, Coenraad J. Hattingh, Jean-Paul Fouché, Bruce Spottiswoode, Paul D. Carey, Christine Lochner, Dan J. Stein

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2012

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Abstract

While a number of studies have explored the functional neuroanatomy of social anxiety disorder (SAD), data on grey matter integrity are lacking. We conducted structural MRI scans to examine the cortical thickness of grey matter in individuals with SAD. 13 unmedicated adult patients with a primary diagnosis of generalized social anxiety disorder and 13 demographically (age, gender and education) matched healthy controls underwent 3T structural magnetic resonance imaging. Cortical thickness and subcortical volumes were estimated using an automated algorithm (Freesurfer Version 4.5). Compared to controls, social anxiety disorder patients showed significant bilateral cortical thinning in the fusiform and post central regions. Additionally, right hemisphere specific thinning was found in the frontal, temporal, parietal and insular cortices of individuals with social anxiety disorder. Although uncorrected cortical grey matter volumes were significantly lower in individuals with SAD, we did not detect volumetric differences in corrected amygdala, hippocampal or cortical grey matter volumes across study groups. Structural differences in grey matter thickness between SAD patients and controls highlight the diffuse neuroanatomical networks involved in both social anxiety and social behavior. Additional work is needed to investigate the causal mechanisms involved in such structural abnormalities in SAD.

Adolphs R, Damasio H, Tranel D (1996) Cortical systems for the recognition of emotion in facial expressions. J ….

Amir N, Klumpp H, Elias J, Bedwell JS, Yanasak N, Miller LS (2005) Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. BPS 57(9):975–981. doi:10.1016/j.biopsych.2005.01.044

Association AP (2000) Diagnostic and statistical manual of mental disorders DSM-IV-TR fourth edition (text revision) (4th ed. p. 943). Amer Psychiatric Pub

Aylward E, Minshew N, Goldstein G (1999) MRI volumes of amygdala and hippocampus in non–mentally retarded autistic adolescents and adults. Neurol

Bandelow B, Stein DJ (2004) Social anxiety disorder (p. 366). Informa HealthCare

Beaton EA, Schmidt LA, Schulkin J, Antony MM, Swinson RP, Hall GB (2009) Different fusiform activity to stranger and personally familiar faces in shy and social adults. Soc Neurosci 4(4):308–316. doi:10.1080/17470910902801021 PubMedCrossRef

Bechdolf A, Wood SJ, Nelson B, Velakoulis D, Yücel M, Takahashi T, Yung AR et al (2012) Amygdala and insula volumes prior to illness onset in bipolar disorder: a magnetic resonance imaging study. Psychiatr Res 201(1):34–39. doi:10.1016/j.pscychresns.2011.06.010 CrossRef

Beer J, Heerey E, Keltner D (2003) The regulatory function of self-conscious emotion: insights from patients with orbitofrontal damage. J Pers….

Beer JS, John OP, Scabini D, Knight RT (2006) Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions. http://dx.doi.org/10.1162/jocn.2006.18.6.871. MIT Press 238 Main St., Suite 500, Cambridge, MA 02142-1046USA journals-info@mit.edu

Benjamini Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B ….

Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D et al (2008) Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 165(9):1193–1202. doi:10.1176/appi.ajp.2008.07071060 PubMedCrossRef

Brookeman J (1990) Three-dimensional magnetization-prepared rapid gradient-echo imaging (3D MP RAGE). Magn Reson ….

Camus M, Halelamien N, Plassmann H, Shimojo S, O’Doherty J, Camerer C, Rangel A (2009) Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex decreases valuations during food choices. Eur J Neurosci 30(10):1980–1988. doi:10.1111/j.1460-9568.2009.06991.x PubMedCrossRef

Carr L, Iacoboni M, Dubeau M-C, Mazziotta JC, Lenzi GL (2003) Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A 100(9):5497–5502. doi:10.1073/pnas.0935845100 PubMedCrossRef

Cohen MX, Schoene-Bake J-C, Elger CE, Weber B (2009) Connectivity-based segregation of the human striatum predicts personality characteristics. Nat Neurosci 12(1):32–34. doi:10.1038/nn.2228 PubMedCrossRef

Cooney R, Atlas L, Joormann J, Eugène F (2006) Amygdala activation in the processing of neutral faces in social anxiety disorder: is neutral really neutral. Psychiatr Res ….

Critchley HD (2000) The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain 123(11):2203–2212. doi:10.1093/brain/123.11.2203 PubMedCrossRef

Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ (2004) Neural systems supporting interoceptive awareness. Nat Neurosci 7(2):189–195. doi:10.1038/nn1176 PubMedCrossRef

Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. NeuroImage 9(2):179–194. doi:10.1006/nimg.1998.0395 PubMedCrossRef

De Bellis MD, Casey BJ, Dahl RE, Birmaher B, Williamson DE, Thomas KM, Axelson DA et al (2000) A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biol Psychiatry 48(1):51–57. doi:10.1016/S0006-3223(00)00835-0 PubMedCrossRef

Deardorff P, Philip C, Finch JA (1977) Empathy, locus of control and anxiety in college students. Psychol ….

Deary I (2005) Education and mortality: a role for intelligence. J Epidemiol Community Health

Deeley Q, Daly EM, Surguladze S, Page L, Toal F, Robertson D, Curran S et al (2007) An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome. BPS 62(3):207–217. doi:10.1016/j.biopsych.2006.09.037

Demaree HA, Everhart DE, Youngstrom EA, Harrison DW (2005) Brain lateralization of emotional processing: historical roots and a future incorporating “dominance”. Behav Cogn Neurosci Rev 4(1):3–20. doi:10.1177/1534582305276837 PubMedCrossRef

Denkova E, Wong G, Dolcos S, Sung K, Wang L, Coupland N, Dolcos F (2010) The impact of anxiety-inducing distraction on cognitive performance: a combined brain imaging and personality investigation. PLoS One 5(11):e14150. doi:10.1371/journal.pone.0014150 PubMedCrossRef

Desikan R, Ségonne F, Fischl B, Quinn B (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage

Ebisch SJH, Gallese V, Willems RM, Mantini D, Groen WB, Romani GL, Buitelaar JK et al (2011) Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. Hum Brain Mapp 32(7):1013–1028. doi:10.1002/hbm.21085 PubMedCrossRef

Etkin A, Wager TD (2007) Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatr

Fellows LK (2011) Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage. Ann N Y Acad Sci 1239(1):51–58. doi:10.1111/j.1749-6632.2011.06229.x PubMedCrossRef

First MB (1997) User’s guide for the Structured clinical interview for DSM-IV axis I disorders SCID-I. clinician version (p. 132). Amer Psychiatric Pub Inc

Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 97(20):11050–11055. doi:10.1073/pnas.200033797 PubMedCrossRef

Fischl B, Sereno M (1999) Cortical surface-based analysis* 1:: II: inflation, flattening, and a surface-based coordinate system. NeuroImage

Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341–355PubMedCrossRef

Fischl B, Salat DH, van der Kouwe AJW, Makris N, Ségonne F, Quinn BT, Dale AM (2004a) Sequence-independent segmentation of magnetic resonance images. NeuroImage 23(Suppl 1):S69–S84. doi:10.1016/j.neuroimage.2004.07.016 CrossRef

Fischl B, Van Der Kouwe A, Destrieux C (2004b) Automatically parcellating the human cerebral cortex. Cerebr ….

Fornito A, Yücel M, Patti J, Wood SJ, Pantelis C (2009) Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies. Schizophr Res 108(1–3):104–113. doi:10.1016/j.schres.2008.12.011 PubMedCrossRef

Franzen EA, Myers RE (1973) Neural control of social behavior: prefrontal and anterior temporal cortex. Neuropsychologia 11(2):141–157PubMedCrossRef

Fusar-Poli P, Placentino A, Carletti F, Landi P, Allen P, Surguladze S, Benedetti F et al (2009) Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies. J Psychiatr Neurosci JPN 34(6):418–432

Gentili C, Gobbini M, Ricciardi E, Vanello N (2008) Differential modulation of neural activity throughout the distributed neural system for face perception in patients with Social Phobia and healthy subjects. Brain Res

Glosser G, Zwil AS, Glosser DS, O’Connor MJ, Sperling MR (2000) Psychiatric aspects of temporal lobe epilepsy before and after anterior temporal lobectomy. J Neurol Neurosurg Psychiatry 68(1):53–58PubMedCrossRef

Goldin PR, Manber T, Hakimi S, Canli T, Gross JJ (2009) Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Arch Gen Psychiatry 66(2):170–180. doi:10.1001/archgenpsychiatry.2008.525 PubMedCrossRef

Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H (2006) Anatomical differences in the mirror neuron system and social cognition network in autism. Cerebr Cortex (New York, NY: 1991) 16(9):1276–1282. doi:10.1093/cercor/bhj069 CrossRef

Hahn A, Stein P, Windischberger C, Weissenbacher A, Spindelegger C, Moser E, Kasper S et al (2011) Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder. NeuroImage 56(3):881–889. doi:10.1016/j.neuroimage.2011.02.064 PubMedCrossRef

Hampton AN, Adolphs R, Tyszka JM, O’Doherty JP (2007) Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex. Neuron 55(4):545–555. doi:10.1016/j.neuron.2007.07.022 PubMedCrossRef

Heimberg RG, Horner KJ, Juster HR, Safren SA, Brown EJ, Schneier FR, Liebowitz MR (1999) Psychometric properties of the liebowitz social anxiety scale. Psychol Med 29(1):199–212PubMedCrossRef

Irle E, Ruhleder M, Lange C, Seidler-Brandler U, Salzer S, Dechent P, Weniger G et al (2010) Reduced amygdalar and hippocampal size in adults with generalized social phobia. J Psychiatr Neurosci JPN 35(2):126–131

Kaufman AS (2009) IQ testing 101 (p. 347). Springer Pub Co

Kaufman AS, Lichtenberger EO (2006) Assessing adolescent and adult intelligence (p. 796). Wiley

Klumpp H, Angstadt M (2011) Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biol Psychol

Kucharska-Pietura K, Phillips ML, Gernand W, David AS (2003) Perception of emotions from faces and voices following unilateral brain damage. Neuropsychologia 41(8):1082–1090PubMedCrossRef

Lebreton M, Barnes A, Miettunen J (2009) The brain structural disposition to social interaction. Eur J ….

Leibowitz M (1987) Liebowitz social anxiety scale. Mod Probl Pharmacopsychiatr 22:141–173

Leslie KR, Johnson-Frey SH, Grafton ST (2004) Functional imaging of face and hand imitation: towards a motor theory of empathy. NeuroImage 21(2):601–607. doi:10.1016/j.neuroimage.2003.09.038 PubMedCrossRef

Liao W, Qiu C, Gentili C, Walter M, Pan Z, Ding J, Zhang W et al (2010) Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study. PLoS One 5(12):e15238. doi:10.1371/journal.pone.0015238 PubMedCrossRef

Liao W, Xu Q, Mantini D, Ding J, Machado-de-Sousa JP, Hallak JEC, Trzesniak C et al (2011) Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res 1388(C):167–177. doi:10.1016/j.brainres.2011.03.018, Elsevier B.VPubMedCrossRef

Lorberbaum J, Kose S, Johnson M (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. NeuroReport

Mesulam MM, Mufson EJ (1982) Insula of the old world monkey. III: efferent cortical output and comments on function. J Comp Neurol 212(1):38–52. doi:10.1002/cne.902120104 PubMedCrossRef

Miyahara M, Harada T, Ruffman T, Sadato N, Iidaka T (2011) Functional connectivity between amygdala and facial regions involved in recognition of facial threat. Soc Cognit Affect Neurosci. doi:10.1093/scan/nsr085

Monk CS, Telzer EH, Mogg K, Bradley BP, Mai X, Louro HMC, Chen G et al (2008) Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 65(5):568–576. doi:10.1001/archpsyc.65.5.568 PubMedCrossRef

Narumoto J, Okada T, Sadato N, Fukui K, Yonekura Y (2001) Attention to emotion modulates fMRI activity in human right superior temporal sulcus. Brain Res Cogn Brain Res 12(2):225–231PubMedCrossRef

Negd M, Mallan KM, Lipp OV (2011) The role of anxiety and perspective-taking strategy on affective empathic responses. Behav Res Ther 49(12):852–857. doi:10.1016/j.brat.2011.09.008 PubMedCrossRef

Newman-Norlund RD, Ganesh S, van Schie HT, De Bruijn ERA, Bekkering H (2009) Self-identification and empathy modulate error-related brain activity during the observation of penalty shots between friend and foe. Soc Cogn Affect Neurosci 4(1):10–22. doi:10.1093/scan/nsn028 PubMedCrossRef

Ochsner KN, Gross JJ (2005) The cognitive control of emotion. Trends Cogn Sci 9(5):242–249. doi:10.1016/j.tics.2005.03.010 PubMedCrossRef

Olson IR, Plotzker A, Ezzyat Y (2007) The enigmatic temporal pole: a review of findings on social and emotional processing. Brain 130(7):1718–1731. doi:10.1093/brain/awm052 PubMedCrossRef

Paulus MP, Stein MB (2010) Interoception in anxiety and depression. Brain Struct Funct 214(5–6):451–463. doi:10.1007/s00429-010-0258-9 PubMedCrossRef

Petrides M, Pandya DN (2007) Efferent association pathways from the rostral prefrontal cortex in the macaque monkey. J Neurosci 27(43):11573–11586. doi:10.1523/JNEUROSCI.2419-07.2007 PubMedCrossRef

Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. NeuroImage 16(2):331–348. doi:10.1006/nimg.2002.1087 PubMedCrossRef

Phan K, Fitzgerald D, Nathan P (2006) Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatr

Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I, Arfanakis K (2009) Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry 66(7):691–694. doi:10.1016/j.biopsych.2009.02.028 PubMedCrossRef

Potts N, Davidson J (1994) Magnetic resonance imaging in social phobia. Psychiatr Res ….

Prehn-Kristensen A, Wiesner C, Bergmann TO, Wolff S, Jansen O, Mehdorn HM, Ferstl R et al (2009) Induction of empathy by the smell of anxiety. PLoS One 4(6):e5987. doi:10.1371/journal.pone.0005987 PubMedCrossRef

Preston S, De Waal F (2002) Empathy: its ultimate and proximate bases. Behav Brain ….

Pujol J, Harrison BJ, Ortiz H, Deus J, Soriano-Mas C, López-Solà M, Yücel M et al (2009) Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychol Med 39(7):1177–1187. doi:10.1017/S003329170800500X PubMedCrossRef

Rizzolatti G (2004) The mirror-neuron system. Annu Rev Neurosci

Sabatinelli D, Bradley MM, Fitzsimmons JR, Lang PJ (2005) Parallel amygdala and inferotemporal activation reflect emotional intensity and fear relevance. NeuroImage 24(4):1265–1270. doi:10.1016/j.neuroimage.2004.12.015 PubMedCrossRef

Sareen J, Campbell D, Leslie W, Malisza K (2007) Striatal function in generalized social phobia: a functional magnetic resonance imaging study. Biol ….

Schultz RT, Grelotti DJ, Klin A, Kleinman J, Van der Gaag C, Marois R, Skudlarski P (2003) The role of the fusiform face area in social cognition: implications for the pathobiology of autism. Phil Trans Roy Soc B Biol Sci 358(1430):415–427. doi:10.1098/rstb.2002.1208 CrossRef

Snowden JS, Gibbons ZC, Blackshaw A, Doubleday E, Thompson J, Craufurd D, Foster J et al (2003) Social cognition in frontotemporal dementia and Huntington’s disease. Neuropsychologia 41(6):688–701PubMedCrossRef

Snowden JS, Thompson JC, Neary D (2004) Knowledge of famous faces and names in semantic dementia. Brain 127(Pt 4):860–872. doi:10.1093/brain/awh099 PubMedCrossRef

Stein M (2008) Social anxiety disorder. Lancet

Stein MB, Goldin PR, Sareen J, Zorrilla LTE, Brown GG (2002) Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 59(11):1027–1034PubMedCrossRef

Straube T, Kolassa I-T, Glauer M, Mentzel H-J, Miltner WHR (2004) Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biol Psychiatry 56(12):921–930. doi:10.1016/j.biopsych.2004.09.024 PubMedCrossRef

Thompson SA, Patterson K, Hodges JR (2003) Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Neurology 61(9):1196–1203PubMedCrossRef

van Tol M-J, van der Wee NJA, van den Heuvel OA, Nielen MMA, Demenescu LR, Aleman A, Renken R et al (2010) Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 67(10):1002–1011. doi:10.1001/archgenpsychiatry.2010.121 PubMedCrossRef

Vollm B, Taylor A, Richardson P, Corcoran R (2006) Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. NeuroImage

Vuilleumier P, Richardson MP, Armony JL, Driver J, Dolan RJ (2004) Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat Neurosci 7(11):1271–1278. doi:10.1038/nn1341 PubMedCrossRef

Waiter GD, Williams JHG, Murray AD, Gilchrist A, Perrett DI, Whiten A (2004) A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder. NeuroImage 22(2):619–625. doi:10.1016/j.neuroimage.2004.02.029 PubMedCrossRef

Wallace GL, Dankner N, Kenworthy L, Giedd JN, Martin A (2010) Age-related temporal and parietal cortical thinning in autism spectrum disorders. Brain 133(12):3745–3754. doi:10.1093/brain/awq279 PubMedCrossRef

Wood JN (2003) Social cognition and the prefrontal cortex. Behav Cogn Neurosci Rev 2(2):97–114. doi:10.1177/1534582303002002002 PubMedCrossRef

Yamasaki S, Yamasue H, Abe O, Suga M, Yamada H, Inoue H, Kuwabara H et al (2010) Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders. BPS 68(12):1141–1147. doi:10.1016/j.biopsych.2010.07.012, Elsevier Inc

Zhou W, Hou P, Zhou Y, Chen D (2011) Reduced recruitment of orbitofrontal cortex to human social chemosensory cues in social anxiety. NeuroImage 55(3):1401–1406. doi:10.1016/j.neuroimage.2010.12.064, Elsevier IncPubMedCrossRef

Titel: Grey matter abnormalities in social anxiety disorder: a pilot study
verfasst von: Supriya Syal
Coenraad J. Hattingh
Jean-Paul Fouché
Bruce Spottiswoode
Paul D. Carey
Christine Lochner
Dan J. Stein
Publikationsdatum: 01.09.2012
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2012
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-012-9299-5

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