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01.04.2013 | Gastrointestinal

Hepatocellular carcinoma in cirrhotic patients: prospective comparison of US, CT and MR imaging

verfasst von: Michele Di Martino, Gianmaria De Filippis, Adriano De Santis, Daniel Geiger, Maurizio Del Monte, Concetta Valentina Lombardo, Massimo Rossi, Stefano Ginanni Corradini, Gianluca Mennini, Carlo Catalano

Erschienen in: European Radiology | Ausgabe 4/2013

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Abstract

Objectives

To prospectively compare the diagnostic performance of ultrasound (US), multidetector computed tomography (MDCT) and contrast-enhanced magnetic resonance imaging (MRI) in cirrhotic patients who were candidates for liver transplantation.

Methods

One hundred and forty consecutive patients with 163 hepatocellular carcinoma (HCC) nodules underwent US, MRI and MDCT. Diagnosis of HCC was based on pathological findings or substantial growth at 12-month follow-up. Four different image datasets were evaluated: US, MDCT, MRI unenhanced and dynamic phases, MRI unenhanced dynamic and hepatobiliary phase. Diagnostic accuracy, sensitivity, specificity, PPV and NPV, with corresponding 95 % confidence intervals, were determined. Statistical analysis was performed for all lesions and for three lesion subgroups (<1 cm, 1-2 cm, >2 cm).

Results

Significantly higher diagnostic accuracy, sensitivity and NPV was achieved on dynamic + hepatobiliary phase MRI compared with US, MDCT and dynamic phase MRI alone. The specificity and PPV of US was significantly lower than that of MDCT, dynamic phase MRI and dynamic + hepatobiliary phase MRI. Similar results were obtained for all sub-group analyses, with particular benefit for the diagnosis of smaller lesions between 1 and 2 cm.

Conclusions

Dynamic + hepatobiliary phase MRI improved detection and characterisation of HCC in cirrhotic patients. The greatest benefit is for diagnosing lesions between 1 and 2 cm.

Key Points

• US, CT and MRI can all identify HCC in cirrhotic patients

• US has good sensitivity but suffers from false-positive findings

• Dynamic CT and MR have similar diagnostic performance for diagnosing HCC

• Dynamic + hepatobiliary phase MRI significantly improves detection and characterisation of HCC

• The greatest benefit is for the diagnosis of lesions between 1 and 2 cm

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Titel: Hepatocellular carcinoma in cirrhotic patients: prospective comparison of US, CT and MR imaging
verfasst von: Michele Di Martino
Gianmaria De Filippis
Adriano De Santis
Daniel Geiger
Maurizio Del Monte
Concetta Valentina Lombardo
Massimo Rossi
Stefano Ginanni Corradini
Gianluca Mennini
Carlo Catalano
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 4/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2691-z

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Hepatocellular carcinoma in cirrhotic patients: prospective comparison of US, CT and MR imaging