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01.06.2014 | Original Research

Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers

verfasst von: Guang Si Shen, Qing Yang, Jing Long Jian, Guo Yang Zhao, Lu Lin Liu, Xiao Wang, Wen Zhang, Xi Huang, You Jia Xu

Erschienen in: Calcified Tissue International | Ausgabe 6/2014

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Abstract

Iron accumulation is a risk factor of osteoporosis; mechanisms leading to iron-related bone loss are not fully determined. We sought to better understand the effect of chronic iron accumulation on bone over the life span in a mouse model. Hepcidin1 knockout (Hepc1 ^−/−) male mice and their littermate control wild type (WT) mice at 7 months old were used in this study. Serum iron and ferritin as well as iron contents in liver and femur were significantly increased in Hepc1 ^−/− mice compared to WT mice. We found that Hepc1 ^−/− mice had a phenotype of low bone mass and alteration of the bone microarchitecture, most likely caused by a decreased osteoblastic activity. Cell culture studies indicated that chronic iron accumulation decreased bone formation, probably by affecting bone morphogenetic protein signaling.

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Titel: Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers
verfasst von: Guang Si Shen
Qing Yang
Jing Long Jian
Guo Yang Zhao
Lu Lin Liu
Xiao Wang
Wen Zhang
Xi Huang
You Jia Xu
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 6/2014
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-014-9845-8

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